Sarcoidosis Accompanied by Systemic Lupus Erythematosus and Autoimmune Hepatitis

Abstract

Abstract

Comorbid autoimmune diseases in patients with sarcoidosis: A nationwide case–control study in Taiwan

“…The remaining two diseases, SLE and psoriasis, were not uncommon in Taiwan with prevalence of 97.5 and 278.3 per 100 000 population, respectively . There are increasing reports supporting the coexistence of SLE and sarcoidosis with approximately 30 cases reported in the English‐language published work, including four Asian cases . A recent large hospital‐based study in the UK showed significant association between SLE and sarcoidosis (aOR, 8.33; 95% CI, 2.71–19.4) .…”

“…The association of sarcoidosis with several other autoimmune comorbid diseases as frequently reported before was not demonstrated in our analysis, such as celiac disease, autoimmune hepatitis, inflammatory bowel disease, MS, systemic sclerosis, SLE and psoriasis. 5,9,11,[15][16][17][18][20][21][22][23]35 There were marked racial differences in the prevalence of the first five diseases as mentioned above with the Westerners being more predisposed to those autoimmune comorbidities than the Asian people. [36][37][38][39][40] Hence, the different comorbidity profiles disclosed in our analysis may be attributed to the low prevalence of those diseases in the Taiwanese.…”

“…41,42 There are increasing reports supporting the coexistence of SLE and sarcoidosis with approximately 30 cases reported in the English-language published work, including four Asian cases. 9,11,15,16,[20][21][22]43 A recent large hospital-based study in the UK showed significant association between SLE and sarcoidosis (aOR, 8.33; 95% CI, 2.71-19.4). 11 In our study, the prevalence of SLE in the control group was consistent with a previous nationwide survey in Taiwan, 42 which suggested that the matched control group we sampled could represent the population.…”

“…5 However, the correlation between autoimmune diseases and sarcoidosis has been reported frequently, including systemic lupus erythematosus (SLE), autoimmune hepatitis, celiac disease, systemic sclerosis, rheumatoid arthritis (RA), Sj€ ogren's syndrome (SS), ankylosing spondylitis (AS), hypothyroidism and Graves' disease. 2,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Nevertheless, most of these studies fall into the category of either case reports 8,10,[13][14][15][16][17][18][19][20][21][22] or small to medium hospital-based studies, 6,7,9 and the clinical significance of the association remains unclear. The main objective of this nationwide population-based case-control study in Taiwan is to clarify the autoimmune profiles in sarcoidosis patients.…”

High rate of cardiac sarcoidosis presenting with cutaneous plaque type sarcoidosis in 18F-fluorodeoxyglucose positron emission tomography-computed tomography: a case series

“…Sarcoidosis is accompanied by many complications, which include various autoimmune diseases that may cause lymphadenopathy [7,8]. Our patients had Sjögren syndrome, rheumatoid arthritis, Hashimoto disease and positive ANAs (×1280).…”