High rate of cardiac sarcoidosis presenting with cutaneous plaque type sarcoidosis in 18F-fluorodeoxyglucose positron emission tomography-computed tomography: a case series

Nakamura, Satoshi; Hashimoto, Yuichi; Takeda, Keiko; Mizumoto, Toshihiro; Demitsu, Toshio; Iizuka, Hajime

doi:10.1186/1752-1947-8-17

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…Scaling and central atrophy sometimes suggest other dermatoses like chronic discoid lupus erythematosus, granuloma annulare, psoriasis, discoid eczema, syphilis, mycosis fungoides, tinea corporis, leishmaniasis, non-tuberculous mycobacteriosis of the skin, tuberculosis cutis serpiginosa, and lichen planus (5,18). Plaque-type sarcoidosis shows an association with cardiac involvement as demonstrated by 18F-fluorodeoxyglucose positron emission tomography-computed tomography (25).…”

Section: Clinical Manifestations and Differential Diagnosismentioning

confidence: 99%

The “Mystery” of Cutaneous Sarcoidosis: Facts and Controversies

Tchernev

Cardoso

Chokoeva

et al. 2014

Int J Immunopathol Pharmacol

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The reason why the cutaneous form of sarcoidosis is well known in the literature is because of its spectrum of manifestations granting it the fame of a Great Imitator. The mystery shrouding the pathogenesis of this rare cutaneous disease is still there (in spite of the fundamental progress of the various diagnostic methods in current day medicine). The production of the morphological substrate-the epithelioid cell granuloma-which is considered to be characteristic of skin sarcoidosis, could, however, also be the end result of a reaction to i) various specific infectious agents such as Leishmaniasis cutis, coccidioidomycosis, etc., ii) certain residual bacterial or other mycobacterial antigens which, at the moment of setting the diagnosis are-by definition-non-infectious but still immunogenic, as well as iii) different tumor antigens in lesional tissue or other location. Often, differentiating between sarcodiosis and a sarcoid-like reaction, based on the updated criteria for cutaneous sarcoidosis, is problematic to downright impossible. A future characterization of the genetic signature of the two conditions, as well as the implementation of additional mandatory panels for i) the identification of certain infectious or ii) non-infectious but immunogenic and iii) tumor antigens in the epithelioid cell granuloma (or in another location in the organism), could be a considerable contribution to the process of differentiating between the two above-mentioned conditions. This will create conditions for greater accuracy when setting the subsequent therapeutic approaches.

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Section: Clinical Manifestations and Differential Diagnosismentioning

confidence: 99%

The “Mystery” of Cutaneous Sarcoidosis: Facts and Controversies

Tchernev

Cardoso

Chokoeva

et al. 2014

Int J Immunopathol Pharmacol

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“…It is elevated in roughly 60% of cases with no diagnostic or prognostic significance. A positron emission tomography scan can be considered to detect asymptomatic systemic involvement, especially cardiac, and can also show enhancement of cutaneous granulomatous inflammation . The role of dermoscopy and local part ultrasound has been explored for both diagnosis and monitoring during treatment …”

Section: Discussionmentioning

confidence: 99%

A Man With Infiltrated Plaques on the Pretibial Area

Bhattacharjee

Chatterjee

2018

JAMA Dermatol

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A man in his late 20s presented with mildly itchy, erythematous plaques of 3 months' duration on both legs. The lesions started to appear on the left pretibial region as small papules, which gradually increased in size and coalesced to form bigger plaques. No history of local trauma, prolonged standing, and occupational exposure to mineral dust or recent drug intake was recollected. He was not diabetic. On examination, large, ill-defined, erythematous plaques were present on the pretibial areas extending onto the lateral aspect of both legs. The plaques were surmounted by multiple, discrete atrophic scars. The periphery of the plaques showed increased vascularity in the form of telangiectasias and venous prominences, along with atrophy of the overlying skin (Figure , A). There were no lesions elsewhere on the body. A skin biopsy sample was obtained from the plaque and sent for histopathological examination (Figure , B and C). Diagnosis C. Cutaneous sarcoidosis Clinical Review & Education

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