Sarcoid Reactions and Sarcoidosis in Hodgkin's Disease and Other Malignant Lymphomata

Brincker, H

doi:10.1038/bjc.1972.18

Cited by 160 publications

(78 citation statements)

References 19 publications

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“…In 1972 a Danish analysis of about 1,500 cases of malignant lymphoma disclosed five patients who also had sarcoidosis [3], a high rate in view of a previously reported annual sarcoidosis incidence in Denmark of 5/100,000 population [4]. In concordance with this observation, a subsequent registry study showed a higher prevalence than expected of malignant neoplasms among patients reported to a nationwide Danish Sarcoidosis Registry [4] in the period of 1962-1971 [5].…”

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confidence: 77%

Sarcoidosis and cancer revisited: a long-term follow-up study of 555 Danish sarcoidosis patients

Fk¹,

Hommelgaard²,

Schou³

1998

Eur Respir J

131

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For more than 20 yrs it has been debated whether the systemic disease sarcoidosis predisposes to malignant neoplasms. The aim of this study was to examine the occurrence of cancer in Danish sarcoidosis patients observed for 9-30 yrs. The clinical data of 555 consecutive sarcoidosis patients were linked with the nationwide Danish Cancer Registry in a database, comparing the results with the expected incidence in the Danish population, adjusted for sex, age and calendar time. The sarcoidosis patients were diagnosed in two areas during the periods of 1960-1971 and 1970-1981, respectively, and followed until December 31, 1991. No excess of cancer was observed in sarcoidosis patients. A total number of 48 patients were observed with cancer (20 males and 28 females). Cancer occurred 1-29 yrs after sarcoidosis diagnosis (median 14 yrs) The observed versus expected (O/E) ratio was 1.16 (95% confidence interval (CI) 0.75-1.79) in males and 1.28 (95% CI 0.88-1.86) in females. No increased occurrence of lung cancer or malignant lymphoma (O/E ratios 0.23, 95% CI 0.00-1.25 and 1.25, 95% CI 0.02-6.95, respectively) was found. Neither age at diagnosis of sarcoidosis nor clinical sarcoidosis features were indicators of later occurrence of malignancy. The study could not confirm previous reports of an increased occurrence of malignant neoplasms in Danish sarcoidosis patients.

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confidence: 77%

Sarcoidosis and cancer revisited: a long-term follow-up study of 555 Danish sarcoidosis patients

Fk¹,

Hommelgaard²,

Schou³

1998

Eur Respir J

131

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“…However, cases 1 and 2 presented with Hodgkin's disease with lymph-node biopsies also containing EPCG, and clinical signs of sarcoidosis did not appear until 5 and 17 years later, respectively. Cases 1 and 3 were kindly pointed out to the author by other physicians, cases 4 and 5 surfaced as a result of a nation-wide study of Hodgkin's disease (Nordentoft et al, 1980), and cases 9 and 10 were found as a result of an epidemiological study of 2,544 patients with respiratory sarcoidosis (Brincker & Wilbek, 1974 (Brincker, 1972) Nine cases of associated neoplastic disease were found, 7 of which were malignant tumours (Table IV). Remarkably, these 9 cases occurred in only 5 patients.…”

Section: Methodsmentioning

confidence: 98%

The sarcoidosis-lymphoma syndrome

Brincker¹

1986

Br J Cancer

267

156

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Analysis of 17 cases of coexistent sarcoidosis and malignant lymphoproliferative disease, supplemented with 29 similar cases reported in the literature indicates that this association is not fortuitous. In addition, significantly more malignancies other than lymphoma were found in this group of patients. A sarcoidosis-lymphoma syndrome appears to exist in which malignant lympho-proliferative disease develops at least 5.5 times more often than expected in middle-aged patients with chronic active sarcoidosis, possibly as a consequence of the immunologic abnormalities observed in the latter disease.

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“…The expected incidence goes up gradually because the patients' age increases during the observation period; hence the risk of cancer also increases. It is striking that the observed cancer incidence is very high during the first 4 follow-up years; thereafter it drops to the normal level or per- (Sakula, 1963) or malignant lymphomata (Brincker, 1972); this reaction should not be considered as sarcoidosis disease.…”

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confidence: 99%

“…Case histories which show an association between sarcoidosis and malignant lymphomata or lung cancer have been reviewed by Brincker (1972) and Sakula (1963). These studies did not allow estimation of the frequency of the association of sarcoidosis with a malignancy.…”

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confidence: 99%