Sarcoid heart disease--results of follow-up investigations

Schaedel, H; Kirsten, D; Schmidt, Andrea; Schmidt, H; Strauss, H.-J.

doi:10.1093/eurheartj/12.suppl_d.26

Cited by 20 publications

(12 citation statements)

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“…[284][285][286][287]. However, the Stanford group reported that in three cases in which cardiac transplantation was performed, the prognosis was favorable [284].…”

Section: Cardiac Transplantationmentioning

confidence: 99%

“…The prognosis of patients with cardiac sarcoidosis seems to be improving, to some extent, due to the use of various types of new agents, such as antiarrhythmic drugs, and the use of pacemaking and defibrillation devices; however, the prognosis has not been clearly shown to improve on an overall basis, especially in cases with cardiac dysfunction (Table 2) [272][273][274][275][276][277][278][279][280][281][282][283][284][285][286][287][288]. here are no reports as yet on the use of betaadrenergic blockers.…”

Section: Cause Of Death and Prognosismentioning

confidence: 99%

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Cardiac sarcoidosis: Diagnostic, prognostic, and therapeutic considerations

Sekiguchi

Yazaki

Isobe

et al. 1996

Cardiovasc Drug Ther

151

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Cardiac involvement in patients with sarcoidosis is an important consideration for those who are concerned with this strange disease. Sarcoidosis is not an acute malignant disease but may be noticed at the time of sudden, expected death as fatal myocardial sarcoidosis at autopsy. Even with modern advances in our ability to diagnose heart disease, cardiac sarcoidosis is still often overlooked because of its subclinical disease progression. In view of this, an extensive review of previously published literature and of our own case analyses has been carried out because of the authors' long-term experience with performing Konno's endomyocardial biopsy, which was originally developed in 1962 at the author's institution. However, the sensitivity of endomyocardial biopsy in detecting sarcoid granuloma is low (20-30%), and, instead, various kinds of nongranulomatous pathologies are often seen. During the course of our research it was found that there might exist a racial difference in cardiac sarcoidosis. Cardiac death was much more frequent in Japanese patients. The possibility that heart disease in sarcoidosis is caused by cor pulmonale due to advanced pulmonary fibrosis should be reevaluated because only a limited amount of background data is available. The author's review clarified the fact that cardiac sarcoidosis is caused by myocardial or pericardial involvement, resulting in various kinds of bradyarrhythmias or tachyarrhythmias and/or congestive heart failure. Electrocardiographic (ECG) and Holter monitor readings provide a simple and effective method for early detection of this disease. The incidence of ECG abnormalities in a total of 963 sarcoidosis patients was 22.1%, which was more frequent than that of the sex- and age-matched healthy control subjects (17.9%; p < 0.025). Echocardiography and radionuclide studies also provide useful clinical information. Careful follow-up and early corticosteroid administration followed by small maintenance doses may prevent the progression of the disease and improve prognosis. Owing to the progress in antiarrhythmic drugs and pacemaker implantation, the primary cause of death in cardiac sarcoidosis has changed from sudden death (1976 report) to congestive heart failure (1985 report).

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“…[284][285][286][287]. However, the Stanford group reported that in three cases in which cardiac transplantation was performed, the prognosis was favorable [284].…”

Section: Cardiac Transplantationmentioning

confidence: 99%

Section: Cause Of Death and Prognosismentioning

confidence: 99%

Cardiac sarcoidosis: Diagnostic, prognostic, and therapeutic considerations

Sekiguchi

Yazaki

Isobe

et al. 1996

Cardiovasc Drug Ther

151

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“…When ejection fraction is lower than 35%, certain authors recommend as first line a cardioverter defibrillator [168]. When facing a ''normal'' ejection fraction, conduction and rhythm disturbances correspond to a better prognosis [29,35,46,60,97,116,171] with a regression obtained in 92% of cases [8].…”

Section: Stratification Of Riskmentioning

confidence: 99%

“…Finally, heart transplantation can be performed. Indications are the same as all other cardiomyopathies [35,48,59,159,166,171,180,181,[185][186][187][188]. CS diagnostic is frequently done during the histologic examination of the heart [167].…”

Section: Cardiologic Treatmentmentioning

confidence: 99%

Cardiac sarcoidosis

Chapelon-Abric

2012

La Presse Médicale

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“…So zeigten die Nachuntersuchungen in Bad Berka, dass in einem Drittel der Fäl-le die Herzsarkoidose erst dann klinisch auffällig wurde, nachdem die Lungensarkoidose sich radiologisch normalisiert hatte [21]. Daher sollte auch bei jungen Patienten mit unklaren Herzrhythmusstörungen oder Myokardveränderungen differenzialdiagnostisch an eine Sarkoidose gedacht werden.…”

Section: Epidemiologieunclassified

Kardiale Sarkoidose

Schulte¹,

Costabel²,

Kirsten³

2003

Pneumologie

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Sarcoidosis is a systemic disease, in which early inflammatory organic changes, which are often reversible under treatment, may take a subclinical course. In scarred residual tissue improvement id rare. Continuing functional loss or even organ failure is possible. The involvement of the heart is of essential prognostic value. Early onset of treatment with corticosteroids before irreversible functional loss of the heart occurs leads to an excellent prognosis. Technical progress in the imaging techniques have led to great improvement of the graphical presentation of cardiac structure and function, but not one of these techniques has yet been approved of for early diagnosis. Still, a combination of different diagnostical measures in addition to the evaluation of clinical symptoms often allows early diagnosis. A decisive factor is "to consider it" and a timely start of further diagnostics if certain symptoms are presented. Alternatives to the specific treatment with cortisone are still lacking. Symptomatic cardiac treatment is mainly oriented on the therapy of dilatory cardiomyopathies, since there are no reliable systematic studies available on questions concerning, for example, antiarrhythmic treatment or indications for the implantations of pacemakers in connection with cardiac sarcoidosis.

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Sarcoid heart disease--results of follow-up investigations

Cited by 20 publications

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Cardiac sarcoidosis: Diagnostic, prognostic, and therapeutic considerations

Cardiac sarcoidosis: Diagnostic, prognostic, and therapeutic considerations

Cardiac sarcoidosis

Kardiale Sarkoidose

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