SARC‐F and SARC‐CalF are associated with sarcopenia traits in hemodialysis patients

Duarte, Marvery P.; Ribeiro, Heitor Siqueira; Almeida, Lucas S.; Baião, Victor M.; Inda-Filho, Antônio; Avesani, Carla María; Ferreira, Aparecido Pimentel; Lima, Ricardo Moreno

doi:10.1002/ncp.10819

Cited by 8 publications

(10 citation statements)

References 45 publications

(128 reference statements)

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“…[31][32][33][34] Additionally, SARC-CalF demonstrated higher sensitivity compared with SARC-F in patients undergoing HD. 35 CC has also been suggested as a component of the sarcopenia screening tool proposed by Ishii et al 36 and for the SARC-CalF score. 31 The CC measurement is one of the tests recommended by the Asian Working Group for Sarcopenia (AWGS) as a screening tool for sarcopenia.…”

Section: Discussionmentioning

confidence: 99%

“…Multiple studies evaluating the diagnostic accuracy of SARC‐CalF found that its performance in screening for sarcopenia was enhanced by incorporating CC measurements 31–34 . Additionally, SARC‐CalF demonstrated higher sensitivity compared with SARC‐F in patients undergoing HD 35 . CC has also been suggested as a component of the sarcopenia screening tool proposed by Ishii et al 36 and for the SARC‐CalF score 31 .…”

Section: Discussionmentioning

confidence: 99%

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Calf circumference predicts sarcopenia in maintenance hemodialysis

Özcan,

Güner,

Ceylan

et al. 2023

Nut in Clin Prac

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BackgroundEarly recognition of sarcopenia in hemodialysis (HD) patients will be of great importance in preventing adverse outcomes and improving the quality of life in these patients. The main goal of this study was to evaluate the diagnostic accuracy of calf circumference (CC) measurement in detecting sarcopenia among CKD patients undergoing maintenance HD.MethodsThis cross‐sectional study included 52 patients (53 ± 17 years) who were currently in a maintenance HD. Muscle strength was evaluated using handgrip strength, and smooth muscle mass index (SMI) was assessed through bioelectrical impedance analysis, and CC was measured at the widest part of the calf with the foot pressed against a hard surface.ResultsOut of the total patient population, sarcopenia was identified in 32.7% (n = 17). The two groups were comparable in terms of age, weight, and height, but the median body mass index of sarcopenic group was statistically lower than nonsarcopenic group (21.6 kg/m2 [18.9–24.6] vs 24.7 kg/m2 [21.4–27.3]. The sarcopenic group had a substantially smaller CC than the nonsarcopenic group (30.0 cm [26.5–32.0] vs 31.5 cm [30.3–34.8], P = 0.013; respectively). In the regression analysis, CC was found to be independently associated with post‐HD SMI (P < 0.001; odds ratio, 1.938; and 95% CI, 1.020–2.856). CC was positively but weakly correlated with handgrip strength, however strong and significant correlation was found between CC and SMI (r = 0.277, P = 0.047 and r = 0.733, P < 0.001; respectively). A CC of 31 cm or less predicted confirmed sarcopenia in HD patients (area under the curve = 0.709, P = 0.006, specificity = 0.556, sensitivity = 0.765).ConclusionsLow muscle mass and potentially low muscle strength in HD patients can be accurately identified through the use of CC measurements. Specifically, a CC measurement below 31 cm has found to be a useful indicator to identify individuals on maintenance HD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Calf circumference predicts sarcopenia in maintenance hemodialysis

Özcan,

Güner,

Ceylan

et al. 2023

Nut in Clin Prac

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“…Also, the SARC-F questionnaire was developed as a rapid screening tool for sarcopenia, and updated versions have been proposed since then, such as the SARC-CalF which by adding a calf circumference measurement has been shown to increase the sensibility to detect sarcopenia in patients on haemodialysis. 38 Moreover, these findings highlight the critical need for clinicians to prescribe effective targeted interventions that may counterattack this phenomenon, such as resistance exercise training and adequate caloric and protein intake. 39 Moreover, we encourage the use of a consensus definition based on the geographic location where it is available, for example, the AWGS for Asians, the EWGSOP2 for Europeans, and the FNIH for North Americans.…”

Section: Clinical Applicabilitymentioning

confidence: 99%

Prevalence of sarcopenia in patients with chronic kidney disease: a global systematic review and meta‐analysis

Duarte,

Almeida,

Neri

et al. 2024

J cachexia sarcopenia muscle

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Sarcopenia is a risk factor for adverse clinical outcomes in chronic kidney disease (CKD) patients, including mortality. Diagnosis depends on adopted consensus definition and cutoff values; thus, prevalence rates are generally heterogeneous. We conducted a systematic review and meta‐analysis to investigate the global prevalence of sarcopenia and its traits across the wide spectrum of CKD. A systematic search was conducted using databases, including MEDLINE and EMBASE, for observational studies reporting the prevalence of sarcopenia. We considered sarcopenia according to the consensus definition of the European Working Group on Sarcopenia in Older People (EWGSOP), the Asian Working Group for Sarcopenia, the Foundation for the National Institutes of Health Sarcopenia Project, and the International Working Group on Sarcopenia (IWGS). Subgroup analyses by CKD stages, consensus, and gender were performed. Pooled prevalence was obtained from random‐effect models. A total of 140 studies (42 041 patients) across 25 countries were included in this systematic review and meta‐analyses. Global prevalence of sarcopenia was 24.5% [95% confidence interval (CI): 20.9–28.3) and did not differ among stages (P = 0.33). Prevalence varied according to the consensus definition from 11% to 30%, with no significant difference (P = 0.42). Prevalence of severe sarcopenia was 21.0% (95% CI: 11.7–32.0), with higher rates for patients on dialysis (26.2%, 95% CI: 16.6–37.1) compared to non‐dialysis (3.0%, 95% CI: 0–11.1; P < 0.01). Sarcopenic obesity was observed in 10.8% (95% CI: 3.5–21.2). Regarding sarcopenia traits, low muscle strength was found in 43.4% (95%CI: 35.0–51.9), low muscle mass in 29.1% (95% CI: 23.9–34.5), and low physical performance in 38.6 (95% CI: 30.9–46.6) for overall CKD. Prevalence was only higher in patients on dialysis (50.0%, 95% CI: 41.7–57.4) compared to non‐dialysis (19.6%, 95% CI: 12.8–27.3; P < 0.01) for low muscle strength. We found a high global prevalence of sarcopenia in the wide spectrum of CKD. Low muscle strength, the primary sarcopenia trait, was found in almost half of the overall population with CKD. Patients on dialysis were more prevalent to low muscle strength and severe sarcopenia. Nephrology professionals should be aware of regularly assessing sarcopenia and its traits in patients with CKD, especially those on dialysis.

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“…The Asian Working Group for Sarcopenia 2019 recommends the use of CC as a method to diagnose sarcopenia because of its high sensitivity and specificity in the Asian population [ 5 – 7 ]. According to previous studies, a lot of diseases have close links to CC, such as sarcopenia, disability, non-alcoholic fatty liver, type 2 diabetes, and so on [ 8 – 10 ]. Moreover, CC can predict nutritional risks in old adults and forecast mortality among patients [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Calf circumference predicts frailty in older adults: the Chinese longitudinal healthy longevity survey

Wang

Chen

et al. 2022

BMC Geriatr

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Background Although frailty is a common geriatric syndrome in old adults, a simple method to assess the degree of frailty in a person has not yet been established. In this study we have tried to establish the association between calf circumference (CC) and frailty among older Chinese people. Methods We used the data obtained from the 2014 edition of the Chinese Longitudinal Healthy Longevity Survey; 1216 participants aged ≥60 years were included for the study. Body mass index, CC and waist circumference measurement data, and laboratory test results were collected. Frailty status was measured using the frailty index (FI). Participants were then classified into non-frail (FI < 0.25) and frail (FI ≥ 0.25) groups. Results There were 874 participants (71.9%) in the non-frail group and 342 (28.1%) in the frail group. The CC was significantly different between the two groups (31.54 ± 4.16 versus 28.04 ± 4.53, P < 0.001). Logistic regression analysis revealed that CC (odds ratio = 0.947, 95% confidence interval: 0.904–0.993, P = 0.023) was an independent impact factor associated with frailty. The CC value of 28.5 cm was considered the best cut-off value in women with area under the curve (AUC) was 0.732 (P < 0.001) and 29.5 cm in men with AUC was 0.592 (P = 0.004);We created a simple prediction model for frailty that included age,sex and CC:$$\textrm{Logit}(P)=-9.756+0.123\ast \textrm{Age}-0.512\ast \textrm{Sex}\left(\textrm{man}=1,\textrm{woman}=0\right)-0.053\ast \textrm{CC},$$ Logit ( P ) = - 9.756 + 0.123 * Age - 0.512 * Sex man = 1 , woman = 0 - 0.053 * CC , P = elogit(P) /1 + elogit(P), and AUC is 0.849 (P < 0.001). Conclusions CC is a convenient and predictable marker of frailty in older adults.

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SARC‐F and SARC‐CalF are associated with sarcopenia traits in hemodialysis patients

Cited by 8 publications

References 45 publications

Calf circumference predicts sarcopenia in maintenance hemodialysis

Calf circumference predicts sarcopenia in maintenance hemodialysis

Prevalence of sarcopenia in patients with chronic kidney disease: a global systematic review and meta‐analysis

Calf circumference predicts frailty in older adults: the Chinese longitudinal healthy longevity survey

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