Sapota (<i>Manilkara achras</i>Forb.)

Madani, Babak; Mirshekari, Amin; Yahia, Elhadi M.; Golding, Jonathan M.

doi:10.1002/9781119431077.ch4

Cited by 7 publications

(9 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antiulcer activity of extract may refer its mechanism similar to CCB, as Ca +2 is known for such effects as explored earlier [ 21 ]. Ficus palmata has been reported for its antioxidant and nitric oxide free radical scavenging activities, so the antiulcer effect is due to its antioxidant property [ 22 ]. Fp.Aq in comparison with chloroform fraction has more potency to cure ulcerogenic stomach, so Fp.Aq treatment in animals was used for further analysis of IHC and H&E staining [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Proteomic Analysis and In Vivo Studies Reveal the Potential Gastroprotective Effects of CHCl3 and Aqueous Extracts of Ficus palmata

Ansari

Khan

Qazi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Ficus palmata is rich in several phytochemicals such as chromone, isoflavones, terpenes, lignans, coumarins, glycosides, and furanocoumarins and have been traditionally used for the management of different gastrointestinal disorders. This research reveals the effects of Ficus palmata fruit extracts—Ficus palmata chloroform (Fp.CHCl3) and Ficus palmata aqueous (Fp.Aq)—on gut activity through in vivo and in vitro analyses. Antidiarrheal and enteropooling assays were analyzed with castor oil-induced diarrhea and intestinal fluid accumulation. Jejunum tissues of rabbits were isolated (antispasmodic) for in vitro experiments. Antimotility was carried out by charcoal meal for determining transient time, and ethanol-induced ulcer assay was used to measure the ulceration of stomach; molecular pathways were assessed through proteomic approach. Fp.CHCl3 and Fp.Aq extracts attributed dose-dependently protection against diarrhea, and intestinal fluid secretions were inhibited dose dependently. Extracts of Fp.CHCl3 and Fp.Aq produced reduction in spontaneous and K+ (at 80 Mm)-induced contractions in isolated jejunum tissues, along with the decreased length covered by charcoal in charcoal meal transient time activity. The extract exhibited gastroprotective outcome in rats and reduced tumor necrotic factor (TNF-α) levels and IL-18, measured by proteomic approach. Morphological studies’ results showed that ethanol induced significant gastritis, apoptosis, swelling of mucosa, and hydropic degeneration leading to cellular degeneration and necrosis, observed through staining techniques. Furthermore, ethanol activated the inflammation pathway in all gastric zones by elevating the levels of cyclooxygenase-2, TNF-α, and nuclear factor kappa light-chain enhancer of activated B-cells. Overall results expressed the antidiarrheal, antispasmodic, enteropooling, antimotility, and antiulcer activities of Ficus palmata fruit extract.

show abstract

Section: Discussionmentioning

confidence: 99%

Proteomic Analysis and In Vivo Studies Reveal the Potential Gastroprotective Effects of CHCl3 and Aqueous Extracts of Ficus palmata

Ansari

Khan

Qazi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…In pathophysiology of gastric ulcers, oxidative stress plays a vital role. Antioxidant and nitric oxide free radical scavenging activity has been reported by Manilkara zapota , which may be responsible for its effectiveness as antiulcer agent [3]. Furthermore, ELISA was done to quantify the protein expression of IL-18, and Mz.Aq significantly attenuates necrosis in ulcerative tissue as compared to Mz.CHCl 3 achieved through proteomic analysis [15].…”

Section: Discussionmentioning

confidence: 99%

“…commonly known as Sapodilla or Naseberry is a terrestrial photosynthetic epiphytic plant with a Mediterranean distribution and about 8–15 m in height, and it belons to the family Sapotaceae; tillage is found easily throughout the regions of Asia, though Manilkara zapota Linn. originates in Mexico and Central America [3]. Fruits are edible and sweet with rich fine flavor and seeds are aperients, diuretic tonic, and febrifuge.…”

Section: Introductionmentioning

confidence: 99%

In Vivo, Proteomic, and In Silico Investigation of Sapodilla for Therapeutic Potential in Gastrointestinal Disorders

Ansari

Khan

Qazi

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

This study aims to delineate the effects of Manilkara zapota Linn. (Sapodilla) fruit chloroform (Mz.CHCl3) and aqueous (Mz.Aq) extracts tested through different techniques. Antidiarrheal activity and intestinal fluid accumulation were examined by using castor oil-induced diarrhea and castor oil fluid accumulation models. Isolated rabbit jejunum tissues were employed for in vitro experiments. Antimotility and antiulcer were performed through charcoal meal transient time and ethanol-induced ulcer assay, molecular studies were conducted through proteomic analysis, and virtual screening was performed by using a discovery studio visualizer (DSV). Mz.CHCl3 and Mz.Aq extracts attributed dose-dependent (50–300 mg/kg) protection (20–100%) against castor oil-induced diarrhea and dose-dependently (50–300 mg/kg) inhibited intestinal fluid secretions in mice. Mz.CHCl3 and Mz.Aq extracts produce relaxation of spontaneous and K+ (80 Mm) induced contractions in isolated tissue preparations and decreased the distance moved by charcoal in the gastrointestinal transit model in rats. It showed gastroprotective effect in ulcerative stomach of rats and decreased levels of IL-18 quantified by proteomic analysis. Histopathological results showed ethanol-induced significant gastric injury, leading to cloudy swelling, hydropic degeneration, apoptosis, and focal necrosis in all gastric zones using hematoxylin and eosin (H&E) staining. Moreover, ethanol increased the activation and the expression of tumor necrotic factor (TNF-α), cyclooxygenase (COX-2), and nuclear factor kappa-light-chain-enhancer of activated B cells (p-NFκB). In silico results were comparative to in vitro results evaluated through virtual screening. Moreover, ethanol increased the activation and expression of tumor necrotic factor, cyclooxygenase, and nuclear factor kappa-light-chain-enhancer of activated B cells. This study exhibits the gastroprotective effect of Manilkara zapota extracts in the peritoneal cavity using a proteomic and in silico approach which reveals different energy values against target proteins, which mediate the gastrointestinal functions.

show abstract

“…The botanical classification of chicozapote fruit is currently a subject of discussion. Several authors assert that it falls within the berry category (10)(11)(12)(13)(14) whereas others suggest that it may be more appropriately classified as a drupe (15). The fruit may be round, oblate, or oval; ranges from 5 to 9 cm in diameter and weighs 70-300 g (5).…”

Section: Introductionmentioning

confidence: 99%

“…Post-harvest management is complex because of its high respiration and ripening rates; thus, its natural pH is close to neutral, making it prone to accelerated microbial spoilage, resulting in a highly perishable product ( 14 ). Decay is the main limitation of post-harvest shelf-life, and thus, rapid senescence ( 5 , 13 ). Although low-temperature storage can extend shelf-life, the fruit is prone to chill injuries at temperatures below 4°C ( 13 ); nevertheless, different attempts have been made to extend the post-harvest shelf-life.…”

Section: Introductionmentioning

confidence: 99%

Manilkara zapota “chicozapote” as a fruit source of health-beneficial bioactive compounds and its effects on chronic degenerative and infectious diseases, a review

Rivas-Gastelum,

Garcia-Amezquita,

Garcia-Varela

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

Manilkara zapota “chicozapote” is an autochthonous evergreen tree from the Southern regions of Mexico, Belize, and Guatemala. Currently, it is widely distributed and extensively grown in Mexico and Southeast Asia. Traditionally, different structures of the plant have been used for medical purposes; seeds have diuretic and purgative properties, aiding in digestive complications and eliminating bladder and kidney stones. Tree bark has antidiarrheal, antipyretic, antibiotic, and astringent properties. Fruits and leaves have been used to treat cold, cough, diarrhea, indigestion, fever, hemorrhages, wounds, and ulcers. Chicozapote fruit is yellow and brown, with an oval shape and rough peel, it is an excellent source of nutrients, such as sugars, proteins, amino acids, and minerals, and is rich in phytochemical components, such as flavonoids, phenolic acids, and tannins. These bioactive compounds exert several biological activities, i.e., as an antioxidant, antidiabetic, antimicrobial, anti-inflammatory, cytotoxic, and anti-arthritic agents, to name a few. These beneficial properties assist in preventing chronic and degenerative diseases, such as cancer, diabetes, neurological, infectious, and cardiovascular diseases. The use of chicozapote is still limited to its fresh form, and its non-edible structures produce a lot of waste. Therefore, an alternative valorizing and preserving strategy is to use the fruit as a raw source to design functional foods and pharmacological products. Here, the nutritional and phytochemical profiles and the current view regarding methodologies and conditions, for the extraction and characterization of its bioactive compounds, are described, and focus is placed on their multiple biological effects and specific functional mechanisms.

show abstract

Sapota (Manilkara achrasForb.)

Cited by 7 publications

References 55 publications

Proteomic Analysis and In Vivo Studies Reveal the Potential Gastroprotective Effects of CHCl3 and Aqueous Extracts of Ficus palmata

Proteomic Analysis and In Vivo Studies Reveal the Potential Gastroprotective Effects of CHCl3 and Aqueous Extracts of Ficus palmata

In Vivo, Proteomic, and In Silico Investigation of Sapodilla for Therapeutic Potential in Gastrointestinal Disorders

Manilkara zapota “chicozapote” as a fruit source of health-beneficial bioactive compounds and its effects on chronic degenerative and infectious diseases, a review

Contact Info

Product

Resources

About