Saponins from Tribulus terrestris L. protect human keratinocytes from UVB-induced damage

Sisto, Margherita; Lisi, Sabrina; D'Amore, Mario; Lucro, Raffaella De; Carati, Davide; Castellana, Donatello; Pesa, Velia La; Zuccarello, Vincenzo; Lofrumento, Dario Domenico

doi:10.1016/j.jphotobiol.2012.10.002

Cited by 28 publications

(17 citation statements)

References 30 publications

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“…In addition, GSTT has a preventive efficacy against UVB-induced carcinogenesis. The photo protective effect of GSTT is tightly correlated with the enhancement of NER gene expression and the blocking of UVB-mediated NF-κB activation [ 91 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

Zhu

Meng

et al. 2017

Chemistry Central Journal

129

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Tribulus terrestris L. (TT) is an annual plant of the family Zygophyllaceae that has been used for generations to energize, vitalize, and improve sexual function and physical performance in men. The fruits and roots of TT have been used as a folk medicine for thousands of years in China, India, Sudan, and Pakistan. Numerous bioactive phytochemicals, such as saponins and flavonoids, have been isolated and identified from TT that are responsible alone or in combination for various pharmacological activities. This review provides a comprehensive overview of the traditional applications, phytochemistry, pharmacology and overuse of TT and provides evidence for better medicinal usage of TT.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

Zhu

Meng

et al. 2017

Chemistry Central Journal

129

View full text Add to dashboard Cite

show abstract

“…Moreover, when assessing the concentration of protodioscin in the marketed extracts, only one sample showed protodioscin levels of around 45% of its composition, as recommended by ANVISA. Second, the saponins from Tribulus terrestris are considered cytotoxic (Sisto et al, 2012), mainly for tumor cells, and ovarian cancer cells (Ovcar) are less affected by this cytotoxicity (Hu, Yao, 2002). Considering the very low concentrations of protodioscin in most of the samples evaluated, it was expected that the extracts, including pure protodioscin, would lower cytotoxic activity on the cell lines studied.…”

Section: Resultsmentioning

confidence: 99%

In vitro cytotoxic activity of five commercial samples of Tribulus terrestris Linn in Espírito Santo (Brazil)

Filho

Kampke

Vargas

et al. 2018

Braz. J. Pharm. Sci.

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The objective was to investigate the total saponin and protodioscin concentrations and the cytotoxicity in vitro, of five samples of the plant Tribulus terrestris, commercially available in the metropolitan region of Vitória -Espirito Santo, Brazil, and to compare them with the aqueous extract of the plant. The chromatographic profile and quantification of protodioscin in commercial samples and plant extract were evaluated by LC-MS/MS. The percentage of total saponins were determined by the colorimetric method. Extracts and protodioscin cytotoxicity were analyzed by the MTT assay in three cell lineages: fibroblasts (L929), ovarian cancer (Ovcar3) and murine hepatoma (Hepa1c1c7). All extracts displayed high levels of total saponins (207.2 to 780.3 mg g -1 of dry extract). The chromatographic profile revealed a wide diversity of compounds, and the saponin protodioscin was detected in only two extracts. One extract displayed high cytotoxicity, with IC 50 values of 157.0, 38.2 and 7.4 µg mL -1 for the Ovcar3, Hepa1c1c7 and L929 cell lines, respectively. The other extracts displayed cytotoxic effects only at concentrations equal to or greater than 125.0 µg mL -1 . Surprisingly, the most cytotoxic extract displayed the highest protodioscin concentration. Therefore, it is suggested that these products be marketed with caution, and followed-up by a certified healthcare professional.

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“…Tribulus terrestris is used in treatment of diabetes [4], heart disease [5], liver disease [6], and kidney disease [7]. It also shows antiinflammatory [8], antibacterial [9], anti-oxidant [10][11][12][13] and antitumoral properties [14,15].…”

Section: Introductionmentioning

confidence: 99%

Environmental Applications and Bio-Profiling of <i>Tribulus Terrestris</i>: an Ecofriendly Approach

Arshad¹,

Rahman²,

Qayyum³

et al. 2020

Pol. J. Environ. Stud.

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The antibacterial and antioxidant activity of different parts of Tribulus terrestris, such as leaves and roots, was carried out using methanol and n-hexane as solvents. The leaves of plant have greater extraction yield than roots. The antibacterial activity was checked against both gram positive bacteria (Staphylococcus aureus) and gram negative bacteria (Escherichia coli). Antibacterial activity was performed by disk inhibition method. Leaves show greater antibacterial activity (29 mm and 30 mm) against both S. aureus and E. coli, whereas roots show (16 mm and 21 mm) against both species respectively. Antioxidant activity was carried out by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) scavenging free-radical assay. Leaf extract showed greater antioxidant activity (73%) than that of roots (52%). Total phenolic content (TPC) and total flavonoid content (TFC) were determined by spectrophotometer analysis. The results indicate that leaf extract contains higher phenolic and flavonoid contents (723 mg Gallic acid equivalents (GAE)/g and 476 mg Quercetin equivalents (QE)/g as compared to roots extract (235mg GAE/g and 93 mg QE/g).

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Saponins from Tribulus terrestris L. protect human keratinocytes from UVB-induced damage

Cited by 28 publications

References 30 publications

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

In vitro cytotoxic activity of five commercial samples of Tribulus terrestris Linn in Espírito Santo (Brazil)

Environmental Applications and Bio-Profiling of <i>Tribulus Terrestris</i>: an Ecofriendly Approach

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