(+)-Santonide, a sesquiterpenoid enol lactone derived from <i>Artemisia</i>

Zinczuk, Juán; Rúveda, Edmundo A.; Thompson, H. W.; Lalancette, Roger A.

doi:10.1107/s1600536807007982

Cited by 7 publications

(4 citation statements)

References 6 publications

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“…(+)-Santonide, Fig. 10, is an anthelmintic sesquiterpenoid keto lactone, obtained from various Asia Minor species of Artemisia, that has recently aroused considerable pharmaceutical interest [48].…”

Section: Antimalarial and Other Anti-infective Activitiesmentioning

confidence: 99%

The Artemisia L. Genus

Martínez

Bedoya

Ticona

et al. 2012

Studies in Natural Products Chemistry

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Section: Antimalarial and Other Anti-infective Activitiesmentioning

confidence: 99%

The Artemisia L. Genus

Martínez

Bedoya

Ticona

et al. 2012

Studies in Natural Products Chemistry

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“…288 The structure of several compounds, such as (À)-parasantonic acid, (+)-parasantonide, (À)-isosantonic acid and (+)-santonide, which had been obtained from a-santonin, via santonic acid 332, have been confirmed by X-ray analysis. [289][290][291][292] Chlorahololide A 333 and chlorahololide B 334 are two dimeric lindenane derivatives, which have been isolated from Chloranthus holostegius. These sesquiterpenes were shown to be potent and selective blockers of the potassium channel.…”

Section: Eudesmane and Lindenanementioning

confidence: 99%

Natural sesquiterpenoids

Fraga

2008

Nat. Prod. Rep.

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“…Picrotoxinin and similar sesquiterpene lactones exhibit powerful CNS stimulating effects 8, 9. Alpha‐Santonin was once used as antihelmintic and ascaricidal (however, due to its toxicity it is no longer in use) 10–12. While certain kinds of sesquiterpene lactones show anti‐inflammatory effect (e.g., scandenolide), some others may activate cells involved in inflammatory response (e.g., thapsigargin).…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of phosphaturic mesenchymal tumor (mixed connective tissue type) by cytopathology

William

Laskin

Nayar

et al. 2011

Diagnostic Cytopathology

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Oncogenic osteomalacia (OO) is a rare paraneoplastic condition in which a bone or soft tissue tumor induces biochemical and clinical signs and symptoms of osteomalacia (or rickets) most often by the production of the phosphaturic protein, fibroblast growth factor-23. Phosphaturic mesenchymal tumor, mixed connective tissue type (PMTMCT) is a rare, histologically distinct tumor that represents the most common cause of OO. As the clinical diagnosis of OO is typically suspected on the basis of clinical and biochemical features and the presence of a bone or soft tissue tumor, cytologic examination might potentially provide the necessary pathologic confirmation of OO. In this case of a 46-year-old female with clinical stigmata of OO and a right distal humeral mass, we report that the fine-needle aspiration findings of short, cytologically bland spindled cells embedded in a fine, fibrillary stromal-rich matrix and the presence of osteoclast-type giant cells associated with the stromal matrix provide strong pathological evidence for PMTMCT and assist in pathologically confirming the clinical impression of OO, thus alleviating the need for a more invasive diagnostic surgical procedure.

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(+)-Santonide, a sesquiterpenoid enol lactone derived from Artemisia

Abstract: Key indicatorsSingle-crystal X-ray study T = 100 K Mean (C-C) = 0.002 Å R factor = 0.025 wR factor = 0.060 Data-to-parameter ratio = 12.1 For details of how these key indicators were automatically derived from the article, see

Cited by 7 publications

References 6 publications

The Artemisia L. Genus

The Artemisia L. Genus

Natural sesquiterpenoids

Diagnosis of phosphaturic mesenchymal tumor (mixed connective tissue type) by cytopathology

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