The Artemisia L. Genus

Martínez, María José Abad; Bedoya, Luis Miguel; Ticona, Luis Apaza; Bermejo, Paulina

doi:10.1016/b978-0-444-59514-0.00002-x

Cited by 34 publications

(5 citation statements)

References 60 publications

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“…This suggest that active extracts on P2X7R can be cytotoxic at higher concentrations, revealing a paradoxal effect of the bioactive compounds on this target. These results are in accordance with previous reports of cell metabolic effect of the tested extracts at these concentrations [35–37] . For Scrophularia , Plantago and Gentiana extracts, a loss of cell metabolism (Figure 1) was observed at the two highest concentrations tested, 100 and 10 μg/mL.…”

Section: Resultssupporting

confidence: 93%

“…These results are in accordance with previous reports of cell metabolic effect of the tested extracts at these concentrations. [35][36][37] For Scrophularia, Plantago and Gentiana extracts, a loss of cell metabolism (Figure 1) was observed at the two highest concentrations tested, 100 and 10 μg/mL. Previously, the dichloromethane extract of the aerial parts of Scrophularia atropatana, showed cytotoxic effects in vitro against MCF-7 human breast cancer cell lines at 300 μg/mL by inhibiting the cell growth and viability and induced apoptosis by decreasing the mRNA expression levels of bcl-2 and increasing the expression of caspase-3 and caspase-9.…”

Section: Antioxidant and Cell Viability Evaluationsmentioning

confidence: 99%

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P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants

Ortíz

Šavikin

Massicot

et al. 2023

Chemistry & Biodiversity

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Medicinal plants used in European folk medicine attached to Lamiales, Gentianales or Asterales orders are used to treat inflammatory disorders. Many targets have been identified but to date, implication of purinergic receptor P2X7 activation has not yet been investigated. We managed to evaluate the protective effect on P2X7 activation by plant extracts used as anti‐inflammatory in European folk medicine by the YO‐PRO‐1 uptake dye in vitro bioassay. Results revealed that among our selected plants, species from Scrophularia and Plantago genus were able to decrease significantly P2X7 activation (>50 % at 0.1 and 1 μg/mL). UPLC/MS, dereplication and metabolomic analysis of Scrophularia extracts, allowed us to identify the cinnamoyl‐iridoid harpagoside as putative inhibitor of P2X7 activation. These results open a new research field regarding the anti‐inflammatory mechanism of cinnamoyl‐iridoids bearing plants, which may involve the P2X7 receptor.

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Section: Resultssupporting

confidence: 93%

Section: Antioxidant and Cell Viability Evaluationsmentioning

confidence: 99%

P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants

Ortíz

Šavikin

Massicot

et al. 2023

Chemistry & Biodiversity

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“…In Saudi Arabia, decoctions of fresh whole plants is traditionally used to treat diabetes mellitus. 7 The plant has also been used in folk medicine as an anthelmintic, antispasmodic, antirheumatic, and antibacterial agent. Antioxidant, antileishmanial, and antitrypanosomal activities of A. abyssinica essential oil have also been reported.…”

Section: Introductionmentioning

confidence: 99%

Evaluations of the in vivo Laxative Effects of Aqueous Leaf and Stem Extracts of Artemisia Abyssinica in Mice

Ayele,

Kawet

2024

JEP

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Background People frequently complain of long-term constipation. The cost associated with using modern medications to treat constipation is significant, and the probability of encountering side effects is notably high. These limitations restrict their effectiveness in therapy, remain unresolved, and underscore the need for research on alternative therapeutic approaches. Plants of the genus Artemisia have been used to treat constipation. Therefore, the aim of this study was to evaluate the laxative effects of aqueous A. abyssinica leaf and stem extracts of Artemisia abyssinica in mice. Methods The laxative activity of A. abyssinica leaf and stem extracts was evaluated using three models: laxative activity, gastrointestinal motility, and gastrointestinal secretion. In this study, bisacodyl was used as a standard laxative and loperamide was used to induce constipation. Results In the laxative test, 200 (P<0.05) and 400 mg/kg (p<0.01) doses of plant extract significantly increased the percentage of fecal water content. Moreover, the highest dose of extract increased the frequency of defecation after 12 h (p<0.05). In the remaining two models, the experimental plans also showed significantly higher gastrointestinal motility and noticeable accumulation of intestinal fluid. Conclusion The results of this study indicate that aqueous leaf and stem extracts of A. abyssinica have laxative effects.

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“…[ 1 ] Artemisia species have economic values as foods, medicines, cosmetics, and pharmaceutical industry. [ 2–4 ]…”

Section: Introductionmentioning

confidence: 99%

“…[ 3 ] The sesquiterpenes display a broad range of bioactivities, including anti‐inflammatory, anti‐tumor, anti‐bacterial, and anti‐fungal. [ 2 ] Traditionally, Artemisia sieberi is used as an anti‐malarial, antioxidant, anti‐microbial,, cardioprotective, hepatoprotective, and nephroprotective agent. [ 11–14 ] The plant extracts have been reported for the treatment of gastrointestinal ailments, high blood pressure, and parasite infections in human and animals.…”

Section: Introductionmentioning

confidence: 99%

A new Tetrahydrofuran sesquiterpene skeleton from Artemisia sieberi

Mohamed

Albadry

Elshamy

et al. 2020

J Chinese Chemical Soc

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A new Tetrahydrofuran sesquiterpene 7,10‐Epoxy‐10‐methy‐dodeca‐1,6(14)‐diene‐3,4‐diol (1) along with three known Tetrahydrofuran sesquiterpene compounds 2,6,10‐trimethyl‐2,5:7,10‐dioxido‐dodeca‐3,11‐dien‐5‐ol (2), cis‐hydroxydavanone (3), and davana acid (4). All isolated metabolites were tested against MCF‐7, HCT‐116, and HepG‐2 cancer cell lines. Compound 2 showed potent activity against MCF‐7 (IC50 = 26 ± 0.4 μg/ml), HCT‐116 (IC50 = 30.4 ± 0.9 μg/ml), and HepG‐2 (IC50 = 20.5 ± 0.3 μg/ml) cancer cells.

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The Artemisia L. Genus

Cited by 34 publications

References 60 publications

P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants

P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants

Evaluations of the in vivo Laxative Effects of Aqueous Leaf and Stem Extracts of Artemisia Abyssinica in Mice

A new Tetrahydrofuran sesquiterpene skeleton from Artemisia sieberi

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