Sannanine, a new cytotoxic alkaloid from Streptomyces sannanensis

Li, Yiqing; Zheng, Dan; Li, Jun; Han, Li; Cui, Xiao‐Long; Lang, Li; Li, Minggang; Wang, Zhan-You; Zhao, Jing; Huang, Xueshi

doi:10.1038/ja.2009.95

Cited by 12 publications

(6 citation statements)

References 11 publications

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“…Quinoline‐5,8‐diones are also interesting potential anticancer agents. One new compound sannanine ( 54 ) (Figure ) from Streptomyces sannanensis showed cytotoxicity against four human tumor cell lines BGC823 (gastric cancer), PANC1 (pancreatic cancer), HepG2, and NCI‐H460, with IC 50 values of 6.6, 5.8, 3.1, and 1.8 μM, respectively …”

Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 99%

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Biologically active quinoline and quinazoline alkaloids part II

Shang

Morris‐Natschke

Yang

et al. 2018

Medicinal Research Reviews

153

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To follow-up on our prior Part I review, this Part II review summarizes and provides updated literature on novel quinoline and quinazoline alkaloids isolated during the period of 2009-2016, together with the biological activity and the mechanisms of action of these classes of natural products. Over 200 molecules with a broad range of biological activities, including antitumor, antiparasitic and insecticidal, antibacterial and antifungal, cardioprotective, antiviral, anti-inflammatory, hepatoprotective, antioxidant, anti-asthma, antitussive, and other activities, are discussed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.

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Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 99%

“…8) from Streptomyces sannanensis showed cytotoxicity against four human tumor cell lines BGC823 (gastric cancer), PANC1 (pancreatic cancer), HepG2 and NCI-H460, with IC 50 values of 6.6, 5.8, 3.1 and 1.8 μM, respectively. 56…”

Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 99%

Biologically active quinoline and quinazoline alkaloids part II

Shang

Morris‐Natschke

Yang

et al. 2018

Medicinal Research Reviews

153

View full text Add to dashboard Cite

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“…The organism Streptomyces sannanensis and fermentation conditions were identical to those in reference [ 1 ].…”

Section: Methodsmentioning

confidence: 99%

“…In the course of screening for new bioactive compounds from microbial sources, two new constituents, isostreptazolin ( 1 ) and sannaphenol ( 2 ), were isolated from the fermentation broth of Streptomyces sannanensis , from which a new cytotoxic alkaloid, sannanine, had been isolated by the authors in earlier work [ 1 ]. The structures of 1 and 2 were determined by detailed spectroscopic investigation and the results of biological testing for the cytotoxic activity of 1 and 2 are presented.…”

Section: Introductionmentioning

confidence: 99%

Isostreptazolin and Sannaphenol, Two New Metabolites from Streptomyces sannanensis

Zheng

Han

et al. 2012

Molecules

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“…Synthesized compound and derivatives from microbial sources have been studied for the bioactivity. 66 Other compounds present in the extract are 2-amino-4-oxo-3, 4-dihydropteridine-6-carboxylic acid and (E)-2-(3-methoxy-4-(2-phenoxyethoxy) benzylidene) hydrazine-1-carboxamide. The presence of these compounds in the extract may contribute to the observed activity.…”

Section: Cfa-induced Paw Edema Modelmentioning

confidence: 99%

Investigation of anti‐inflammatory and toxicity effects of mangrove‐derived Streptomyces rochei strain VITGAP173

Gomathi

Gothandam

2019

J of Cellular Biochemistry

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Mangrove ecosystems generate the major biodiversity hotspots of actinobacteria. Among the actinobacteria, Streptomyces species are the prolific producers of bioactive natural products. In this study, with research efforts to discover biopotential compounds from marine actinobacteria, 41 actinobacterial strains were isolated from sediment soil sample of Indian mangrove regions. The phylogeny prediction using the 16S rRNA gene sequences revealed that the isolates were related to Streptomyces. Isolates were further screened based on a two‐step process wherein the first step, around nine strains, unveiled the presence of type 1 polyketide synthase gene and dTDP‐glucose 4,6‐dehydratase gene through polymerase chain reaction. As the second step of the screening process, cell viability assay was performed in RAW264.7 cells to assess the toxicity of extracts. Among all the isolates, Streptomyces rochei strain VITGAP173 was subjected to further analysis. To explore the bioactivities, the organic solvent extraction method was utilized to extract the broth culture of VITGAP173. Inhibition of nitric oxide and cyclooxygenase enzymes upon lipopolysaccharide‐induced inflammation were utilized to evaluate the anti‐inflammatory efficacy, and the results showed the potency of VITGAP173 in a dose‐dependent manner. The extract significantly suppressed the messenger RNA levels of the inflammatory mediators such as tumor necrosis factor‐α and interleukin‐6 induced by lipopolysaccharide in RAW264.7 macrophages. The presence of several chemical constituents was identified through gas chromatography‐mass spectrometry analysis of VITGAP173 extract. To achieve the toxicity analysis, oral administration of VITGAP173 extract in Wistar albino rats was carried out to investigate the biochemical parameters, histopathology which revealed its nontoxic nature.

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Sannanine, a new cytotoxic alkaloid from Streptomyces sannanensis

Cited by 12 publications

References 11 publications

Biologically active quinoline and quinazoline alkaloids part II

Biologically active quinoline and quinazoline alkaloids part II

Isostreptazolin and Sannaphenol, Two New Metabolites from Streptomyces sannanensis

Investigation of anti‐inflammatory and toxicity effects of mangrove‐derived Streptomyces rochei strain VITGAP173

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