Sandfly fever in Central Asia and Afghanistan

Gaidamovich, S. Ya.; Khutoretskaya, N. V.; Asyamov, Y. V.; Tsyupa, V. I.; Melnikova, E. E.

doi:10.1007/978-3-7091-9091-3_32

Cited by 9 publications

(5 citation statements)

References 6 publications

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“…GFV has been reported from Sudan, Senegal, Central African Republic, Nigeria, and Benin ( 38 ). KARV occurs in eastern and central Asia ( 7 , 39 , 40 ), as well as Sudan, Egypt, and Nigeria ( 7 ). According to this geographic distribution, GFV seems to be the most likely sand fly–borne phlebovirus to co-occur in Kenya.…”

Section: Discussionmentioning

confidence: 99%

Sand Fly–Associated Phlebovirus with Evidence of Neutralizing Antibodies in Humans, Kenya

Tchouassi¹,

Marklewitz²,

Chepkorir³

et al. 2019

Emerg. Infect. Dis.

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We describe a novel virus, designated Ntepes virus (NPV), isolated from sand flies in Kenya. NPV has the characteristic phlebovirus trisegmented genome architecture and is related to, but distinct from, Gabek Forest phlebovirus. Diverse cell cultures derived from wildlife, livestock, and humans were susceptible to NPV, with pronounced permissiveness in swine and rodent cells. NPV infection of newborn mice caused rapid and fatal illness. Permissiveness for NPV replication in sand fly cells, but not mosquito cells, suggests a vector-specific adaptation. Specific neutralizing antibodies were found in 13.9% (26/187) of human serum samples taken at the site of isolation of NPV as well as a disparate site in northeastern Kenya, suggesting a wide distribution. We identify a novel human-infecting arbovirus and highlight the importance of rural areas in tropical Africa for arbovirus surveillance as well as extending arbovirus surveillance to include hematophagous arthropods other than mosquitoes.

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Section: Discussionmentioning

confidence: 99%

Sand Fly–Associated Phlebovirus with Evidence of Neutralizing Antibodies in Humans, Kenya

Tchouassi¹,

Marklewitz²,

Chepkorir³

et al. 2019

Emerg. Infect. Dis.

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“…KARV and GFV are distinct and form a new species complex within the Sandfly fever group. KARV was originally isolated in Iran in 1959 (Berge, 1975); subsequent KARV isolations and serological evidence of human infection have been reported from Iran, Azerbeijan, Uzbekistan, Turkmenistan, Kyrgyzstan, Tajikistan and Russia (Gaidamovich et al , 1991; Tesh et al , 1976, 1977). GFV was initially isolated in Sudan in 1961 but many subsequent isolates have been obtained in Nigeria, Benin, Senegal and Central African Republic (Kemp et al , 1974).…”

Section: Full Textmentioning

confidence: 99%

Characterization of the Sandfly fever Naples species complex and description of a new Karimabad species complex (genus Phlebovirus, family Bunyaviridae)

Palacios

Tesh

Savji

et al. 2014

Journal of General Virology

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Genomic and antigenic characterization of members of the Sandfly fever Naples virus (SFNV) complex reveals the presence of five clades that differ in their geographical distribution. Saint Floris and Gordil viruses, both found in Africa, form one clade; Punique, Granada and Massilia viruses, all isolated in the western Mediterranean, constitute a second; Toscana virus, a third; SFNV isolates from Italy, Cyprus, Egypt and India form a fourth; while Tehran virus and a Serbian isolate Yu 8/76, represent a fifth. Interestingly, this last clade appears not to express the second non-structural protein ORF. Karimabad virus, previously classified as a member of the SFNV complex, and Gabek Forest virus are distinct and form a new species complex (named Karimabad) in the Phlebovirus genus. In contrast with the high reassortment frequency observed in some South American phleboviruses, the only virus of the SFNV complex with evidence of reassortment was Granada virus. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the US Army.

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“…Three serotypes, Sicilian (SFS), Naples (SFN), and Toscana (TOS), were associated with clinical infections in humans. SFS and SFN infections are endemic in several Mediterranean countries, the Middle East, and Central Asia [2][3][4][5][6][7][8][9], and these viruses are transmitted by bites of the insect vector Phiebotomus papatasi (sandfly) [10,11]. In the early 1980s, TOS was isolated in Italy from Phlebotomus perniciosus [5].…”

Section: Introductionmentioning

confidence: 99%

Serosurvey and laboratory diagnosis of imported sandfly fever virus, serotype Toscana, infection in Germany

et al. 1995

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SUMMARYOf eight acute infections in German tourists caused by sandfly fever virus, serotype Toscana (TOS), and diagnosed clinically and serologically, seven were acquired during visits to Tuscany, Italy, and one to Coimbra, Portugal. An indirect immunofluorescence assay (IFA) using infected cells, and a newly developed enzyme-immunoassay (EIA) using crude virus antigen prepared from infected Vero-E6 cells was used to detect anti-TOS IgM and IgG. In a seroepidemiological survey of 859 health care workers and medical students, anti-TOS IgG was detected in 1-0% by IFA, and in 0 7 % by EIA. In 2034 German patients hospitalized for various diseases, 1 6 % were positive for anti-TOS IgG by IFA, and 0-8 % by EIA. Anti-TOS IgG was detected in 43 samples of commercial immunoglobulins at titres of 10-1000 by EIA. Although the seroprevalence of antibodies to TOS is low in Germany, TOS infection should be considered in patients returning from endemic areas who complain of fever, and headaches, and have symptoms of meningitis.

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Sandfly fever in Central Asia and Afghanistan

Cited by 9 publications

References 6 publications

Sand Fly–Associated Phlebovirus with Evidence of Neutralizing Antibodies in Humans, Kenya

Sand Fly–Associated Phlebovirus with Evidence of Neutralizing Antibodies in Humans, Kenya

Characterization of the Sandfly fever Naples species complex and description of a new Karimabad species complex (genus Phlebovirus, family Bunyaviridae)

Serosurvey and laboratory diagnosis of imported sandfly fever virus, serotype Toscana, infection in Germany

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