Sample preparation of chemical warfare agent simulants on a digital microfluidic (DMF) device using magnetic bead-based solid-phase extraction

Lee, Hyunji; Lee, Seyeong; Jang, Inae; Kim, Jin-Woo; You, Gwangro; Kim, Eun‐Hee; Choi, Kihwan; Lee, Jae‐Hwan; Choi, Sunkyung; Shin, Kwanwoo; Yoon, Myung‐Han; Oh, Han Bin

doi:10.1007/s10404-017-1976-6

Cited by 9 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…successfully extracted chemical warfare agent stimulants using magnetic-bead-based SPE on a completely automated EWOD-MS device [102]. Based on the two plate configuration, the EWOD chip consisted of 14 actuation electrodes and 6 reservoir electrodes to which the sample solution was loaded.…”

Section: Sample Purification and Separationmentioning

confidence: 99%

“…These outstanding characteristic features have enabled the integration of EWOD chips with mass spectrometry (MS) for the analysis of small molecules that are limited by volume. To date, EWOD-MS coupled models have been mostly used as a sample preparation tool for the characterization of chemical and biological species present in food, water and beverage samples, rendering them important for food safety applications [ 71 , 83 , 102 – 104 ]. A novel prototype was proposed by Gorbatsova et al for MS analysis of vitamin samples in an EWOD platform that was interfaced with capillary electrophoretic (CE) separating chambers ( Fig.…”

Section: Applications Of Ewodmentioning

confidence: 99%

“…In addition, other sample preparation procedures such as solid-phase extraction (SPE) commonly used in the food sector for the purification and extraction of chemical compounds suspended in liquid mixtures of foods have been combined with EWOD platforms for on-chip extraction and later analysis of the extracted chemicals using gas chromatography and mass spectrometry. Lee et al successfully extracted chemical warfare agent stimulants using magnetic-bead-based SPE on a completely automated EWOD-MS device [ 102 ]. Based on the two plate configuration, the EWOD chip consisted of 14 actuation electrodes and 6 reservoir electrodes to which the sample solution was loaded.…”

Section: Applications Of Ewodmentioning

confidence: 99%

See 2 more Smart Citations

Electrowetting-on-dielectric (EWOD): Current perspectives and applications in ensuring food safety

Barman¹,

Khan²,

Chatterjee³

et al. 2020

Journal of Food and Drug Analysis

View full text Add to dashboard Cite

Digital microfluidic (DMF) platforms have contributed immensely to the development of multifunctional lab-on-chip systems for performing complete sets of biological and analytical assays. Electrowetting-on-dielectric (EWOD) technology, due to its outstanding flexibility and integrability, has emerged as a promising candidate for such lab-on-chip applications. Triggered by an electrical stimulus, EWOD devices allow precise manipulation of single droplets along the designed electrode arrays without employing external pumps and valves, thereby enhancing the miniaturization and portability of the system towards transcending important laboratory assays in resource-limited settings. In recent years, the simple fabrication process and reprogrammable architecture of EWOD chips have led to their widespread applications in food safety analysis. Various EWOD devices have been developed for the quantitative monitoring of analytes such as food-borne pathogens, heavy metal ions, vitamins, and antioxidants, which are significant in food samples. In this paper, we reviewed the advances and developments in the design of EWOD systems for performing versatile functions starting from sample preparation to sample detection, enabling rapid and high-throughput food analysis.

show abstract

Section: Sample Purification and Separationmentioning

confidence: 99%

Section: Applications Of Ewodmentioning

confidence: 99%

Section: Applications Of Ewodmentioning

confidence: 99%

See 1 more Smart Citation

Electrowetting-on-dielectric (EWOD): Current perspectives and applications in ensuring food safety

Barman¹,

Khan²,

Chatterjee³

et al. 2020

Journal of Food and Drug Analysis

View full text Add to dashboard Cite

show abstract

“…Magnetic silica beads were used as the adsorbent and immobilized in the channel by magnets. In addition to continuous flow mode, Lee and co-workers developed a digital microfluidic device for controlling droplet movement to realize magnetic beads-based SPE . Qian’s group introduced SPME particles into the microchannel and in situ polymerization of them .…”

Section: Size Reduction Accelerationmentioning

confidence: 99%