“Samosa” Pneumoconiosis

Nath, Dhritiman; Vaideeswar, Pradeep; Chaudhary, Jayashri; Vaz, Walter F.

doi:10.1097/paf.0000000000000076

Cited by 3 publications

(1 citation statement)

References 9 publications

(9 reference statements)

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“…Lung injuries as pneumonia, pleurisy, brosis, and haemorrhage were evidenced in rat's lungs of rats that were subjected to talc powder inhalation. Addiction of talc-adulterated marijuana and prolonged inspiration of talc powder by quarry laborers, lead to talc pneumoconiosis, bronchiolar obstruction and bronchiolitis, and may be fatal [11].…”

Section: Introductionmentioning

confidence: 99%

Effect of enclosing terpenoids-rich Boswellia Carterri ethyl acetate extract in binary cyclodextrin based oligomer nano-complex for improving its activity via counteracting ICAM-1, Ilβ4 and LTB4 pathways in respiratory distressed rats

Ibrahim,

mohammed,

Taleb

et al. 2024

Preprint

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Boswellia carterii (BC) resins plants have a long historical background as a treatment for inflammation, as indicated by information originating from multiple countries. Twenty-seven diterpenoids have been identified in ethylacetate and total methanol BC, comprising seventeen boscartins of the cembrane-type diterpenoids and ten boscartols of the prenylaromadendrane-type diterpenoids. Moreover, twenty-one known triterpenoids have also been found, encompassing nine tirucallane-type, six ursane-type, four oleanane-type, and two lupane-type. The cembrane-type diterpenoids hold a significant position in pharmaceutical chemistry and related industries due to their captivating biological characteristics and promising pharmacological potentials. Extraction of BC, creation and assessment of nano sponges loaded with either B. Carterii plant extract or DEX, are the subjects of our current investigation. With the use of ultrasound-assisted synthesis, nano sponges were produced. The entrapment efficiency (EE%) of medications in Nano sponges was examined using spectrophotometry. Nano sponges were characterized using a number of methods. Within Nano sponges, the EE% of medicines varied between 98.52± 0.07 and 99.64± 1.40%. The nano sponges' particle sizes varied from 105.9±15.9 to 166.8±26.3 nm. Drugs released from Nano sponges using the Korsmeyer-Peppas concept. In respiratory distressed rats, the effects of BC plant extract, DEX salt and their nano formulations (D1, D5, P1 and P1), were tested. Treatment significantly reduced ICAM-1, LTB4, and ILβ4 levels and improved histopathologic profiles, when compared to the positive control group. Boswellia extract and its Nano sponge formulation P1 showed promising therapeutic effects. The effect of P1 may be due to synergism between both the extract and the formulation. This effect was achieved by blocking both ICAM-1 and LTB4 pathways, therefore counteracting the effects of talc powder.

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Section: Introductionmentioning

confidence: 99%

Effect of enclosing terpenoids-rich Boswellia Carterri ethyl acetate extract in binary cyclodextrin based oligomer nano-complex for improving its activity via counteracting ICAM-1, Ilβ4 and LTB4 pathways in respiratory distressed rats

Ibrahim,

mohammed,

Taleb

et al. 2024

Preprint

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Toxicological evaluation of clay minerals and derived nanocomposites: A review

Maisanaba

Pichardo

Puerto

et al. 2015

Environmental Research

182

117

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Inhalation of Talc Induces Infiltration of Macrophages and Upregulation of Manganese Superoxide Dismutase in Rats

et al. 2015

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Talc is a mineral that is widely used in cosmetic products, antiseptics, paints, and rubber manufacturing. Although the toxicological effects of talc have been studied extensively, until now no detailed inhalation study of talc focusing on oxidative stress has been done. This repeated 4 weeks whole-body inhalation toxicity study of talc involved Sprague-Dawley rats. Male and female groups of rats were exposed to inhaled talc at 0, 5, 50, and 100 mg/m(3) for 6 hours daily, 5 days/week for 4 weeks. The objective was to identify the 4-week inhalation toxicity of talc and investigate antioxidant activity after exposure to talc. There were no treatment-related symptoms or mortality in rats treated with talc. Glucose (GLU) was decreased significantly in male rats exposed to 50 and 100 mg/m(3) of talc. Histopathological examination revealed infiltration of macrophages on the alveolar walls and spaces near the terminal and respiratory bronchioles. In male and female rats exposed to 100 mg/m(3) talc, expression of superoxide dismutase 2, a typical biological indicator of oxidative damage, was significantly increased. Thus, inhalation of talc induces macrophage aggregations and oxidative damage in the lung.

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“Samosa” Pneumoconiosis

Cited by 3 publications

References 9 publications

Effect of enclosing terpenoids-rich Boswellia Carterri ethyl acetate extract in binary cyclodextrin based oligomer nano-complex for improving its activity via counteracting ICAM-1, Ilβ4 and LTB4 pathways in respiratory distressed rats

Effect of enclosing terpenoids-rich Boswellia Carterri ethyl acetate extract in binary cyclodextrin based oligomer nano-complex for improving its activity via counteracting ICAM-1, Ilβ4 and LTB4 pathways in respiratory distressed rats

Toxicological evaluation of clay minerals and derived nanocomposites: A review

Inhalation of Talc Induces Infiltration of Macrophages and Upregulation of Manganese Superoxide Dismutase in Rats

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