Salvianolic acid A alleviates ischemic brain injury through the inhibition of inflammation and apoptosis and the promotion of neurogenesis in mice

Chien, Mei Yin; Chuang, Cheng‐Hung; Chern, Chang Ming; Liou, Kou Tong; Liu, Der Zen; Hou, Yu Chang; Shen, Yuh Chiang

doi:10.1016/j.freeradbiomed.2016.09.006

Cited by 83 publications

(57 citation statements)

References 32 publications

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“…According to the previous research, inflammatory reaction and neuronal apoptosis have been considered as major pathophysiological mechanisms of stroke. To inhibit inflammatory reactions and reduce inflammatory mediators have been demonstrated to have a good efficacy in clinic …”

Section: Discussionmentioning

confidence: 99%

“…To inhibit inflammatory reactions and reduce inflammatory mediators have been demonstrated to have a good efficacy in clinic. [9] Ligusticum chuanxiong Hort. (CX) is a commonly used traditional medicinal herb which first recorded in 'Shen Nong's Herbal Classic' for the treatment of cerebrovascular and cardiovascular diseases for many centuries.…”

Section: Discussionmentioning

confidence: 99%

“…Previous researches have reported that the progress of neuronal injury and cerebral infarction result from the postischaemic inflammation and apoptosis . A strong activation and release of inflammatory chemokines, cytokines and adhesion molecules were deteriorated with brain injury . It has been demonstrated that inhibition of inflammation expression was effective against ischaemic brain damage.…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7][8] A strong activation and release of inflammatory chemokines, cytokines and adhesion molecules were deteriorated with brain injury. [9] It has been demonstrated that inhibition of inflammation expression was effective against ischaemic brain damage.…”

Section: Introductionmentioning

confidence: 99%

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Anti-inflammatory and anti-apoptotic effects of the combination of Ligusticum chuanxiong and Radix Paeoniae against focal cerebral ischaemia via TLR4/MyD88/MAPK/NF-κB signalling pathway in MCAO rats

Guo

et al. 2017

Journal of Pharmacy and Pharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anti-inflammatory and anti-apoptotic effects of the combination of Ligusticum chuanxiong and Radix Paeoniae against focal cerebral ischaemia via TLR4/MyD88/MAPK/NF-κB signalling pathway in MCAO rats

Guo

et al. 2017

Journal of Pharmacy and Pharmacology

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“…Salvianolic acid (SA) is an extract of Salvia miltiorrhiza Bunge (Danshen), which is a traditional Chinese medicine that has been used within clinical settings for >2,000 years in China (17). Danshen is a perennial herb and within traditional Chinese medicine it is used to improve blood circulation (18). SA is a compound containing multiple salvianolic acids including, salvianolic acid A and B (19).…”

Section: Effects Of Salvianolic Acid On Cerebral Perfusion In Patientmentioning

confidence: 99%

Effects of salvianolic acid on cerebral perfusion in patients after acute stroke: A single‑center randomized controlled trial

et al. 2018

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Hypoperfusion following acute stroke is common in the infarct core and periphery tissues. The present study evaluated the efficacy of salvianolic acid (SA) on the cerebral perfusion of patients who had suffered from acute stroke using perfusion-weighted magnetic resonance imaging (PWI) to examine the blood perfusion of the affected brain tissue prior to and following treatment. Patients who were admitted to PLA 153 Central Hospital within 72 h of acute stroke symptom onset and had a Glasgow coma scale ≥5 were randomized into two groups: SA and control groups. Patients in the SA group were administered SA 0.13 g/day for 14 days. PWI was performed for all patients at admission and post-treatment. The National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) were applied to assess neurological function at admission and 3 months post treatment. A total of 159 patients were enrolled (85 patients in the SA group and 74 patients in the control group). A total of 62 patients in the SA group and 51 patients in the control group exhibited hypoperfusion in the ipsihemisphere of the diffusion-weighted magnetic resonance imaging (DWI) lesion. In addition, relative cerebral blood volume (rCBV), a ratio of the signal value of the region of interest in the same hemisphere of the DWI lesion to that of its mirror in the PWI CBV map, decreased significantly following treatment with SA compared with the control group in patients with hypoperfusion (P=0.02), which were indicated by PWI images at admission, in the DWI lesions or the surrounding areas. Additionally, there was no significant difference in patients with normal perfusion at admission in rCBV in DWI lesions or its surrounding area between the two groups at day 15. However, a significant improvement in NIHSS (P=0.001) and mRS (P=0.005) was indicated in the SA group compared with the control at day 90. The present study indicated that SA may improve the neurological dysfunction of patients with acute stroke, which may be explained by the increased perfusion of hypoperfused brain tissues.

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Glycogen synthase kinase‐3β: A multifaceted player in ischemia‐reperfusion injury and its therapeutic prospects

Li,

Zhang,

Tang

et al. 2024

Journal Cellular Physiology

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Ischemia‐reperfusion injury (IRI) results in irreversible metabolic dysfunction and structural damage to tissues or organs, posing a formidable challenge in the field of organ implantation, cardiothoracic surgery, and general surgery. Glycogen synthase kinase‐3β (GSK‐3β) a multifunctional serine/threonine kinase, is involved in a variety of biological processes, including cell proliferation, apoptosis, and immune response. Phosphorylation of its tyrosine 216 and serine 9 sites positively and negatively regulates the activation and inactivation of the enzyme. Significantly, inhibition or inactivation of GSK‐3β provides protection against IRI, making it a viable target for drug development. Though numerous GSK‐3β inhibitors have been identified to date, the development of therapeutic treatments remains a considerable distance away. In light of this, this review summarizes the complicated network of GSK‐3β roles in IRI. First, we provide an overview of GSK‐3β's basic background. Subsequently, we briefly review the pathological mechanisms of GSK‐3β in accelerating IRI, and highlight the latest progress of GSK‐3β in multiorgan IRI, encompassing heart, brain, kidney, liver, and intestine. Finally, we discuss the current development of GSK‐3β inhibitors in various organ IRI, offering a thorough and insightful reference for GSK‐3β as a potential target for future IRI therapy.

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Salvianolic acid A alleviates ischemic brain injury through the inhibition of inflammation and apoptosis and the promotion of neurogenesis in mice

Cited by 83 publications

References 32 publications

Anti-inflammatory and anti-apoptotic effects of the combination of Ligusticum chuanxiong and Radix Paeoniae against focal cerebral ischaemia via TLR4/MyD88/MAPK/NF-κB signalling pathway in MCAO rats

Anti-inflammatory and anti-apoptotic effects of the combination of Ligusticum chuanxiong and Radix Paeoniae against focal cerebral ischaemia via TLR4/MyD88/MAPK/NF-κB signalling pathway in MCAO rats

Effects of salvianolic acid on cerebral perfusion in patients after acute stroke: A single‑center randomized controlled trial

Glycogen synthase kinase‐3β: A multifaceted player in ischemia‐reperfusion injury and its therapeutic prospects

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