Glycogen synthase kinase‐3β: A multifaceted player in ischemia‐reperfusion injury and its therapeutic prospects
Jiayan Li,
Yan Zhang,
Ran Tang
et al.
Abstract:Ischemia‐reperfusion injury (IRI) results in irreversible metabolic dysfunction and structural damage to tissues or organs, posing a formidable challenge in the field of organ implantation, cardiothoracic surgery, and general surgery. Glycogen synthase kinase‐3β (GSK‐3β) a multifunctional serine/threonine kinase, is involved in a variety of biological processes, including cell proliferation, apoptosis, and immune response. Phosphorylation of its tyrosine 216 and serine 9 sites positively and negatively regulat… Show more
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