Salviae miltiorrhizae and ligustrazine hydrochloride injection combined with mecobalamin for treating diabetic peripheral neuropathy

Abstract

Objective: Currently, it is unclear whether the salviae miltiorrhizae (Danshen Salvia) and ligustrazine hydrochloride (Chuanxiong Chuanxiong) (SMLH) injection combined with mecobalamin can improve diabetic peripheral neuropathy (DPN). We conducted a systematic analysis to evaluate the clinical effects of SMLH injection combined with mecobalamin for treating DPN. Methods: Seven databases, including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wan Fang Database (Wang Fang), Chinese Biomedical Literature Database (CBM), and VIP Database for Chinese Technical Periodicals (VIP) were searched for systematic literature retrieval. Each database was searched up to 2020 to identify randomized controlled trials on DPN treated with SMLH injection combined with mecobalamin. We used the RevMan 5.3 and Stata 14.0 software to assess the risk of bias in the included trials. Results: A total of 15 publications, including 1349 samples, were reviewed. The total effective rate of SMLH injection combined with mecobalamin was 31% higher than that of mecobalamin alone (95% confidence interval [CI] = 1.23–1.38; P < .00001). The experimental group showed a significant increase in the motor conduction velocity (MCV) of the peroneal nerve (weighted mean difference [WMD] = 4.81, 95% CI 3.53–6.09; P < .00001). In addition, SMLH injection combined with mecobalamin showed a statistical significant effect on the sensory conduction velocity (SCV) of the peroneal nerve (WMD = 5.03, 95% CI = 4.16–5.90; P < .00001), and MCV of the median nerve (WMD = 5.38, 95% CI = 4.05–6.72; P < .00001). The WMD for the change in SCV in the median nerve was 4.89 m/s (95% CI = 3.88–5.89; P < .00001). The P-values of the Egger and Begg tests were 0.967 and 0.961, respectively, indicating no publication bias. Subgroup and sensitivity analyses indicated that the results for MCV and SCV of the peroneal nerve and the median nerve were stable. Conclusion: SMLH injection combined with mecobalamin can improve DPN, compared with mecobalamin alone.

Effects of Infrared Combined with Methylcobalamin on the Vibratory Sensory Threshold and Nerve Conduction Velocity of the Lower Extremity in Patients with Diabetic Foot Treatment

“…The 'show effect' and 'effective' was counted as the total effective rate. (2) The vibrosensory thresholds of the two groups before and after treatment were measured by the vibrosensory threshold detector (Bio Thesiometer, USA). (3) The nerve conduction velocity of the lower limbs before and after the treatment in the two groups was calculated, and the conduction velocity of the left/right common peroneal nerve and tibial nerve were measured by neuromyography.…”

“…Different degrees of vascular disease cause lower extremity pain, ulcers, infection and deep tissue damage [ 1 ]. The diabetic foot is prone to recurrence, long duration, and difficult to heal, and patients are prone to poor nutrition due to their excessive consumption, which can lead to amputation in severe cases [ 2 ]. The pathogenesis of diabetic foot is complex, not only related to impaired lipid metabolism, insulin resistance, vascular endothelial function damage caused by long-term hyperglycemia, infection, hypercoagulability and abnormal blood rheology but also closely related to microinflammatory response [ 3 ].…”