Salvage endoscopic submucosal dissection for the esophagus-localized recurrence of esophageal squamous cell cancer after definitive chemoradiotherapy

Koizumi, Shigeto; Jin, Mario; Matsuhashi, Tamotsu; Tawaraya, Shin; Watanabe, Noboru; Sawaguchi, Masayuki; Kanazawa, Noriyoshi; Yamada, Yumi; Onochi, Kengo; Kimura, Yuko; Ohba, Reina; Kataoka, Jinko; Hatakeyma, Natsumi; Mashima, Hirosato; Ohnishi, Hirohide

doi:10.1016/j.gie.2013.09.012

Cited by 30 publications

(35 citation statements)

References 14 publications

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“…14,26 Moreover, it has been made available for use even in salvage ER as a feasible, effective, and safe procedure for local recurrence after definitive CRT for ESCC. 8,27,28 It is hoped that postsalvage ER pathological findings will be further elucidated with the increasing popularity of salvage ESD. Third, recurrences after salvage ER were classified in this study into locoregional recurrences and distant metastases, based on the hypothesis that risk factors for recurrence may vary between these two.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] Salvage endoscopic resection (ER) has now become one of the curative treatments for locally recurrent superficial lesions after definitive CRT for ESCC. [6][7][8] We have previously shown that good long-term survival is achievable with salvage endoscopic mucosal resection (EMR) without serious complications. 9 However, few studies have investigated the clinicopathological risk factors for recurrence after salvage ER.…”

Section: Introductionmentioning

confidence: 99%

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Salvage endoscopic resection (ER) after chemoradiotherapy for esophageal squamous cell carcinoma: What are the risk factors for recurrence after salvage ER?

Hombu

Yano

Hatogai

et al. 2017

Digestive Endoscopy

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Salvage endoscopic resection (ER) after chemoradiotherapy for esophageal squamous cell carcinoma: What are the risk factors for recurrence after salvage ER?

Hombu

Yano

Hatogai

et al. 2017

Digestive Endoscopy

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“…Accordingly, we perform SESD in our institution. A few recent studies have reported that SESD is effective [20, 21]. They advocate consideration of SESD as a treatment option after diagnosis of esophageal superficial recurrence after dCRT for locally advanced esophageal cancer because it can achieve good local control and survival.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies, including these 2, have demonstrated that R0 resection is an important prognostic factor after salvage surgery for esophageal cancer [22-25]. That is, the most important and basic consideration with salvage operation for esophageal cancer after dCRT must be complete removal of all tumor, as indicated by outcomes of SESD after dCRT for advanced cancer [20, 21]. …”

Section: Discussionmentioning

confidence: 99%

Minimally Invasive Salvage Operations for Esophageal Cancer after Definitive Chemoradiotherapy

et al. 2018

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Background/Aims: Because salvage surgery after definitive chemoradiotherapy for esophageal cancer is associated with high postoperative mortality and morbidity, minimally invasive methods are desirable. We analyzed the validity of minimally invasive salvage operations (MISO). Methods: Twenty-five patients underwent salvage operation between 2010 and 2016 in our institution, 10 having undergone right transthoracic salvage esophagectomy (TTSE group), 6 transhiatal salvage esophagectomy (THSE), 6 salvage lymphadenectomy (SLA), and 3 salvage endoscopic submucosal dissection (SESD). Patients who had undergone THSE, SLA, or SESD were categorized as the MISO group. Short- and long-term outcomes were assessed. Results: The mean duration of surgery was significantly shorter in the SLA groups than in the TTSE group (p = 0.0248). Blood loss was significantly less in the SLA than the TTSE group (p = 0.0340). Intensive care unit stay was shorter in the THSE than the TTSE group (p = 0.0412). There was no significant difference in postoperative mortality between the MISO and THSE groups. Postoperative hospital stay was significantly shorter in the SLA than the TTSE group (p = 0.0061). Patients’ survivals did not differ significantly between the MISO and TTSE groups (p = 0.752). Multivariate analysis revealed that residual disease (R0; HR 4.872, 95% CI 1.387–17.110, p = 0.013) was the only independent factor influencing overall survival. Conclusion: MISO is preferable because short-term outcomes are better and long-term outcomes do not differ from those of TTSE.

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“…The 3-year overall survival rate after salvage ESD was 74% [ 8 ]. Koizumi et al [ 9 ] also reported 12 cases of salvage ESD for esophageal SCC after a definitive CRT. The median survival duration after salvage ESD for all patients was 18 months (range, 8 to 70), and 9 of 12 patients have survived [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Endoscopic Submucosal Dissection for Recurrent or Residual Superficial Esophageal Cancer after Chemoradiotherapy: Two Cases

et al. 2015

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We report two cases of endoscopic submucosal dissection (ESD) for recurrent or residual esophageal squamous cell carcinoma (ESCC) lesions after chemoradiotherapy for advanced esophageal cancer. Case 1 involved a 64-year-old man who had previously undergone chemoradiotherapy for advanced ESCC and achieved a complete response (CR) for 22 months, until metachronous recurrent superficial ESCC was detected on follow-up esophagogastroduodenoscopy (EGD). We performed ESD and found no evidence of recurrence for 24 months. Case 2 involved a 59-year-old man who had previously undergone chemoradiotherapy for advanced ESCC. He responded favorably to treatment, and most of the tumor had disappeared on follow-up EGD 4 months later. However, there were two residual superficial esophageal lugol-voiding lesions. We performed ESD, and he had a CR for 32 months thereafter. ESD can be considered a viable treatment option for recurrent or residual superficial ESCC after chemoradiotherapy for advanced esophageal cancer.

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Salvage endoscopic submucosal dissection for the esophagus-localized recurrence of esophageal squamous cell cancer after definitive chemoradiotherapy

Cited by 30 publications

References 14 publications

Salvage endoscopic resection (ER) after chemoradiotherapy for esophageal squamous cell carcinoma: What are the risk factors for recurrence after salvage ER?

Salvage endoscopic resection (ER) after chemoradiotherapy for esophageal squamous cell carcinoma: What are the risk factors for recurrence after salvage ER?

Minimally Invasive Salvage Operations for Esophageal Cancer after Definitive Chemoradiotherapy

Endoscopic Submucosal Dissection for Recurrent or Residual Superficial Esophageal Cancer after Chemoradiotherapy: Two Cases

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