Salutary Effect of Ferulic Acid Against D-Galactosamine Challenged Liver Damage

Shanmugarajan, T. S.; Krishnakumar, E.; Somasundaram, I.; Sivaraman, D.; Arunsundar, M.; Balaji, R.; Sivakumar, Selvaraj

doi:10.3923/jbs.2008.1271.1279

Cited by 15 publications

(6 citation statements)

References 59 publications

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“…Therefore it may be considered a potential molecule for alternative treatments of liver damage. Shanmugarajan et al (2008) further evaluated the protective effects of FA on D-galactosamine, a hepatotoxin employed in studies involving liver disease, because it causes damage (necrosis) similar to the injury resultant of viral hepatitis in humans (Shi et al, 2008). The results showed that the group of male Wistar rats that received pre-treatment (20 mg FA/kg body weight) had Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field 401 increased activity of antioxidant enzymes in liver tissue, significant inhibition of lipid peroxidation and decreased levels of cholesterol, triglycerides and free fatty acids in relation to the control group.…”

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confidence: 99%

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Brenelli

Goldbeck

Santos

et al. 2013

Braz. J. Pharm. Sci.

150

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Ferulic acid is a phenolic acid widely distributed in the plant kingdom. It presents a wide range of potential therapeutic effects useful in the treatments of cancer, diabetes, lung and cardiovascular diseases, as well as hepatic, neuro and photoprotective effects and antimicrobial and anti-inflammatory activities. Overall, the pharmaceutical potential of ferulic acid can be attributed to its ability to scavenge free radicals. However, recent studies have revealed that ferulic acid presents pharmacological properties beyond those related to its antioxidant activity, such as the ability to competitively inhibit HMG-CoA reductase and activate glucokinase, contributing to reduce hypercholesterolemia and hyperglycemia, respectively. The present review addresses ferulic acid dietary sources, the pharmacokinetic profile, antioxidant action mechanisms and therapeutic effects in the treatment and prevention of various diseases, in order to provide a basis for understanding its mechanisms of action as well as its pharmaceutical potential.Uniterms: Ferulic acid/properties. Ferulic acid/antioxidant activity. Ferulic acid/dietary sources. Ferulic acid/therapeutic effects. Natural products. Pharmacognosy.O ácido ferúlico é um ácido fenólico amplamente distribuído no reino vegetal. Ele apresenta uma ampla gama de potenciais efeitos terapêuticos utéis no tratamento do câncer, diabetes, doenças pulmonares e cardiovasculares, bem como efeitos hepáticos, neuro e fotoprotetores, atividades antimicrobianas e antiinflamatórias. O potencial farmacêutico do ácido ferúlico pode ser atribuído à sua capacidade em sequestrar radicais livres. No entanto, estudos recentes revelaram que o ácido ferúlico apresenta propriedades farmacológicas, além da sua atividade antioxidante, como a capacidade de inibir competitivamente a HMG-CoA redutase e ativar a glucoquinase, contribuindo para reduzir a hipercolesterolemia e hiperglicemia, respectivamente. A presente revisão aborda as fontes dietéticas de ácido ferúlico, o perfil farmacocinético, os mecanismos de ação como antioxidante e efeitos terapêuticos no tratamento e prevenção de várias doenças, de modo a proporcionar uma base para a compreensão dos seus mecanismos de ação, bem como os seus potenciais farmacêuticos.Unitermos: Ácido ferúlico/propriedades. Ácido ferúlico/atividade antioxidante. Ácido ferúlico/fontes dietéticas. Ácido ferúlico/efeitos terapêuticos. Produtos naturais. Farmacognosia. INTRODUCTIONNatural antioxidants exhibit therapeutic potential for a variety of diseases such as cancer, diabetes, and cardiovascular and neurodegenerative diseases (Kayahara et al., 1999;Kim et al., 2003;Soobrattee et al., 2005) where free radicals play a key role in development (Prior et al., 1998). Recently there has been increased public and scientific interest in employing natural antioxidants instead of synthetic antioxidants, due to their potential adverse effects on health which may include carcinogenicity (Ito et al., 1983;Würtzen, 1990;Osawa et al., 1990).Antioxidants found in vegetables can ac...

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confidence: 99%

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Brenelli

Goldbeck

Santos

et al. 2013

Braz. J. Pharm. Sci.

150

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“…Alloxan induced diabetic rats fed with ferulic acid demonstrated decreased immunoreactivity of proinflammatory nuclear transcription factor (NF-κB) and inferred its curative effects (Ramar et al, 2012). Ferulic acid administered to rats fed with high cholesterol protected their liver against D-galactosamine, carbon tetrachloride, alcohol and polyunsaturated fatty acid toxicity Shanmugarajan et al, 2008;Srinivasan, Rukkumani, Ram Sudheer, & Menon, 2005). The effect was apparently due to competitive inhibition of HMG-CoA reductase resulting in decreased lipid peroxidation, cholesterol, triacylglycerol and free fatty acids (Jayaprakasam, Vanisree, & Zhang, 2006;Kim et al, 2011).…”

Section: Health Benefitsmentioning

confidence: 96%

Therapeutical properties of ferulic acid and bioavailability enhancement through feruloyl esterase

Swamy

Vijayalakshmi

2015

Journal of Functional Foods

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“…Therefore it may be considered as a potential molecules for alternative treatments of hepatocytes damage. It was further evaluated by a study done by Shanmugarajan et al, 38 which confirmed the protective effects of ferulic acid against D-galactosamine; a hepatotoxin employed in studies involving liver disease, because it causes damage (necrosis) similar to the injury resultant of viral hepatitis in humans. 39 Ferulic acid also has a hepatoprotective effect against toxicity induced in vivo by carbon tetrachloride, as reported by Srinivasan et al,.…”

Section: Discussionmentioning

confidence: 99%

Isolation, Structure Elucidation of Ferulic and Coumaric acids from Fortunella japonica Swingle leaves and their Structure Antioxidant activity relationship

El-gizawy

Hussein

2016

FRA

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Salutary Effect of Ferulic Acid Against D-Galactosamine Challenged Liver Damage

Cited by 15 publications

References 59 publications

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Therapeutical properties of ferulic acid and bioavailability enhancement through feruloyl esterase

Isolation, Structure Elucidation of Ferulic and Coumaric acids from Fortunella japonica Swingle leaves and their Structure Antioxidant activity relationship

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