Therapeutical properties of ferulic acid and bioavailability enhancement through feruloyl esterase

Swamy, Sakthi kumaran Palani; Vijayalakshmi, G.

doi:10.1016/j.jff.2015.06.013

Cited by 32 publications

(7 citation statements)

References 78 publications

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“…They are mainly concentrated in the aleurone layer and outermost pericarp, as well as the testa tissues of the bran [ 8 ]. Ferulic acid (FA), the most abundant phenolic compound in WB, has shown antioxidant, anti-inflammatory, antihypertensive, and anti-arteriosclerotic effects in vitro and in vivo [ 9 ]. The accumulated scientific evidence of health benefits exerted by FA have promoted the interest of researchers to explore the potential use of WB as a resource in the production of functional ingredients [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Enzyme Selection and Hydrolysis under Optimal Conditions Improved Phenolic Acid Solubility, and Antioxidant and Anti-Inflammatory Activities of Wheat Bran

et al. 2020

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Valorization of wheat bran (WB) into new high-value products is of great interest within the framework of sustainability and circular economy. In the present study, we utilized a multi-step approach to extract nutraceutical compounds (phenolic acids) from WB and improved its antioxidant and anti-inflammatory properties through using sequential hydrothermal and enzymatic hydrolysis. Thirteen commercial glycosidases differing in their specific activity were screened and compared for hydrolytic efficiency to release monosaccharides, ferulic acid, and diferulic acid. Ultraflo XL was selected as the desired enzyme treatment on the basis of its higher WB solubilization, as well as its monosaccharide and phenolic acids yields. The relationships between better hydrolytic performance of Ultraflo XL and its particular activity profile were established. To determine the optimum conditions for Ultraflo XL treatment, we tested different factors (solvent pH, incubation temperature, and time) under 15 experiments. A multicomponent analysis (MCA), including central composite design, model fitness, regression coefficients, analysis of variance, 3D response curves, and desirability, was used for processing optimization. A beneficial effect of autoclave treatment on the release of phenolic compounds was also evidenced. The results of MCA showed involvement of linear, quadratic, and interactive effects of processing factors, although solvent pH was the main determinant factor, affecting enzymatic extraction of phenolics and bioactivity of hydrolysates. As compared to control WB, under optimized conditions (47 °C, pH = 4.4, and 20.8 h), WB hydrolysates showed 4.2, 1.5, 2, and 3 times higher content of ferulic acid (FA) and capacity to scavenge oxygen radicals, chelate transition metals, and inhibit monocyte chemoattractant protein-1 secretion in macrophages, respectively. These approaches could be applied for the sustainable utilization of WB, harnessing its nutraceutical potential.

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Section: Introductionmentioning

confidence: 99%

Enzyme Selection and Hydrolysis under Optimal Conditions Improved Phenolic Acid Solubility, and Antioxidant and Anti-Inflammatory Activities of Wheat Bran

et al. 2020

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“…Furthermore, this strain displays probiotic properties and feruloyl esterase (FE) activity, which is capable of releasing antioxidant ferulic acid from its nonbioavailable esterified forms naturally present in vegetable foods ( 2 ). Free ferulic acid can be absorbed in the gut and can exert several health benefits on the host ( 3 ).…”

Section: Genome Announcementmentioning

confidence: 99%

Draft Genome Sequence of the Feruloyl Esterase-Producing Strain Lactobacillus fermentum CRL1446, a Probiotic for Malnutrition

et al. 2018

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“…Various bioactive compounds that used as anticancer are sourced from plants, one of which is hydroxycinnamic acid (Duthie et al, 2000). The hydroxycinnamic acid group and its derivatives are generally found in the form of being bound to other compounds as the main components making up the cell wall structure (Boz, 2015), such as ferulic acid, caffeic acid, and p-coumaric acid (Angelino et al, 2017;Swamy and Govindaswamy, 2015). However, the process of isolation to get active compounds from plants takes a long time and gives little yields.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 3-(3,4-diacetoxyphenyl)acrylic acid and 4-(oxo-3-(piperidin-1-yl)pro-1-en-1-yl)-1,2-phenylendiacetate from 3-(3,4-dihydroxyphenyl)acrylic acid and their toxicity test by Brine Shrimp Lethality Test method

Tahar,

Hariani Soekamto

2023

ICA

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Derivatization 3-(3,4-dihydroxyphenyl)acrylic acid to 3-(3,4-diacetoxyphenyl)acrylic acid (1) and 4-(oxo-3-(piperidin-1-yl)pro-1-en-1-yl)-1,2-phenylendiacetate (3) and its toxicity test has been successfully carried out. Derivatization was carried out through acetylation, chlorination, and amidation reactions. The acetylation reaction was carried out using acetic anhydride in pyridine solvent at room temperature for 4 hours to produce compound 1 as a white amorphous solid with m.p. 181-183oC and yield of 85.68%. The chlorination reaction was carried out using thionyl chloride in toluene solvent at the reflux temperature of 79°C for 4 hours and continued with in situ amidation using piperidine in dichloromethane solvent at room temperature to produce compound 3 as a white crystal with m.p. 139-141oC and yield of 39.45%. The toxicity test of the two compounds against Artemia salina Leach shrimp larvae using probit analysis showed that compounds 1 and 3 were toxic with LC50 values of 8.919 μg/mL and 84.511 μg/mL, respectively. This data shows that the acetylation of 3-(3,4-dihydroxyphenyl)acrylic acid compound (LC50 = 46.50 μg/mL) increases the toxicity to larvae of Artemia salina Leach shrimp. Keywords: 3-(3,4-dihydroxyphenyl)acrylic acid, 3-(3,4-diacetoxyphenyl)acrylic acid, 4-(oxo-3-(piperidin-1-yl)pro-1-en-1-yl)-1,2-phenylendiacetate, Artemia salina Leach.

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Therapeutical properties of ferulic acid and bioavailability enhancement through feruloyl esterase

Cited by 32 publications

References 78 publications

Enzyme Selection and Hydrolysis under Optimal Conditions Improved Phenolic Acid Solubility, and Antioxidant and Anti-Inflammatory Activities of Wheat Bran

Enzyme Selection and Hydrolysis under Optimal Conditions Improved Phenolic Acid Solubility, and Antioxidant and Anti-Inflammatory Activities of Wheat Bran

Draft Genome Sequence of the Feruloyl Esterase-Producing Strain Lactobacillus fermentum CRL1446, a Probiotic for Malnutrition

Synthesis of 3-(3,4-diacetoxyphenyl)acrylic acid and 4-(oxo-3-(piperidin-1-yl)pro-1-en-1-yl)-1,2-phenylendiacetate from 3-(3,4-dihydroxyphenyl)acrylic acid and their toxicity test by Brine Shrimp Lethality Test method

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