Salt-induced reentrant hydrogel of poly(ethylene glycol)–poly(lactide-co-glycolide) block copolymers

Li, Ting; Ci, Tianyuan; Chen, Liang; Yu, Lin; Ding, Jiandong

doi:10.1039/c3py01107k

Cited by 53 publications

(43 citation statements)

References 83 publications

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“…This was because mPEG-PLGAbased micelles usually have high physical stability with or without dilution due to a low critical micelle concentration value of the copolymer. 27,28 Drug release from ABG-PNs was rapid and comparable to that from the cosolvent formulation (Figure 3), supporting that the PNs rapidly dissolved in the medium upon dilution. Sodium oleate was included in the formula to improve the DL because micelles consisting of fatty acids generally show a high ability to solubilize drugs.…”

mentioning

confidence: 72%

Systemic delivery of the anticancer agent arenobufagin using polymeric nanomicelles

Yuan¹,

Xie²,

Su³

et al. 2017

IJN

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Arenobufagin (ABG) is a major active component of toad venom, a traditional Chinese medicine used for cancer therapy. However, poor aqueous solubility limits its pharmacological studies in vivo due to administration difficulties. In this study, we aimed to develop a polymeric nanomicelle (PN) system to enhance the solubility of ABG for effective intravenous delivery. ABG-loaded PNs (ABG-PNs) were prepared with methoxy poly (ethylene glycol)-block-poly ( d , l -lactic-co-glycolic acid) (mPEG-PLGA) using the solvent-diffusion technique. The obtained ABG-PNs were 105 nm in size with a small polydispersity index of 0.08. The entrapment efficiency and drug loading were 71.9% and 4.58%, respectively. Cellular uptake of ABG-PNs was controlled by specific clathrin-mediated endocytosis. In addition, ABG-PNs showed improved drug pharmacokinetics with an increased area under the curve value (a 1.73-fold increase) and a decreased elimination clearance (37.8% decrease). The nanomicelles showed increased drug concentrations in the liver and lung. In contrast, drug concentrations in both heart and brain were decreased. Moreover, the nanomicelles enhanced the anticancer effect of the pure drug probably via increased cellular uptake of drug molecules. In conclusion, the mPEG-PLGA-based nanomicelle system is a satisfactory carrier for the systemic delivery of ABG.

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confidence: 72%

Systemic delivery of the anticancer agent arenobufagin using polymeric nanomicelles

Yuan¹,

Xie²,

Su³

et al. 2017

IJN

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“…Besides highly ordered structure, a percolated micelle network has also been put forward to interpret the internal structure of their temperature-induced physical hydrogels, and in this case, the structure might not be ordered. 156,157 Phase separation is generally controlled by the balance of hydrophobic and hydrophilic segments on the copolymer chain and its effect on the free energy for mixing. 6 The free energy of hydrophobic interactions varies with enthalpy, temperature, and entropy: G = H -T S. The positive enthalpy term H is smaller than the entropy term S, so temperature increase leads to a larger T S, making G negative and favoring hydrophobic interaction.…”

Section: In Situ-forming Hydrogels Prepared Via Hydrophobic Interactionsmentioning

confidence: 99%

Stimuli-Responsive InjectableIn situ-Forming Hydrogels for Regenerative Medicines

Kim

Kwon

et al. 2015

Polymer Reviews

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Research on injectable in situ-forming hydrogels has been conducted in diverse biomedical applications for a long period. These hydrogels exhibit sol-to-gel phase transition in accordance with the external stimuli such as temperature change. Also, unlike the traditional surgical procedures the hydrogels have the distinct properties of easy management and minimal invasiveness via simple aqueous state injections at target sites. Currently, numerous polymer materials have been reported as potential stimulusinduced in situ-forming hydrogels. In this review, a comprehensive overview of the state-of-the-art of these rapidly developing materials has been outlined. In situ-forming hydrogels formed by electrostatic and hydrophobic interactions as well as their mechanistic characteristics and biomedical applications in regenerative medicine have also been discussed. The review concludes with perspectives on the future of stimulus-induced in situ-forming hydrogels.

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“…Re-entrant T gel decreased as salt concentration increased [19] Type of ion Re-entrant T gel decreased as salting-out ability increased according to Hofmeister series [19] MWD under similar Mw or Mn Solubility increased as Mw/Mn increased [20] CMC increased as Mw/Mn increased CGC increased with increased Mw/Mn under both given Mw and given Mn T gel increased with increased Mw/Mn under both given Mw and given Mn…”

Section: Salt Concentrationmentioning

confidence: 99%

“…The transition temperatures varied with the salt concentration and depended on the type of ion, with the trend obeying the Hofmeister series. They also anticipated that virgin gel was formed by the jamming of close-packed micelles, while re-entrant gel was formed by the percolated micelle network [19]. Table 1.…”

Section: Introductionmentioning

confidence: 99%

Structures and Applications of Thermoresponsive Hydrogels and Nanocomposite-Hydrogels Based on Copolymers with Poly (Ethylene Glycol) and Poly (Lactide-Co-Glycolide) Blocks

Maeda

2019

Bioengineering

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Thermoresponsive hydrogels showing biocompatibility and degradability have been under intense investigation for biomedical applications, especially hydrogels composed of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(lactic acid-co-glycolic acid) (PLGA) as first-line materials. Even though various aspects such as gelation behavior, degradation behavior, drug-release behavior, and composition effect have been studied for 20 years since the first report of these hydrogels, there are still many outputs on parameters affecting their gelation, structure, and application. In this review, the current trends of research on linear block copolymers composed of PEG and PLGA during the last 5 years (2014-2019) are summarized. In detail, this review stresses newly found parameters affecting thermoresponsive gelation, findings from structural analysis by simulation, small-angle neutron scattering (SANS), etc., progress in biomedical applications including drug delivery systems and regeneration medicine, and nanocomposites composed of block copolymers with PEG and PLGA and nanomaterials (laponite).

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Salt-induced reentrant hydrogel of poly(ethylene glycol)–poly(lactide-co-glycolide) block copolymers

Cited by 53 publications

References 83 publications

Systemic delivery of the anticancer agent arenobufagin using polymeric nanomicelles

Systemic delivery of the anticancer agent arenobufagin using polymeric nanomicelles

Stimuli-Responsive InjectableIn situ-Forming Hydrogels for Regenerative Medicines

Structures and Applications of Thermoresponsive Hydrogels and Nanocomposite-Hydrogels Based on Copolymers with Poly (Ethylene Glycol) and Poly (Lactide-Co-Glycolide) Blocks

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