Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM

Daimon, Makoto; Sato, Hidenori; Sasaki, Satoshi; Toriyama, Sayumi; Emi, Mitsuru; Muramatsu, Masaaki; Hunt, Steven C.; Hopkins, Paul N.; Karasawa, Shigeru; Wada, Kiriko; Jimbu, Yumi; Kameda, Wataru; Susa, Shinji; Oizumi, Toshihide; Fukao, Akira; Kawata, Satoshi; Kato, Takeshi

doi:10.1016/j.bbrc.2008.07.065

Cited by 22 publications

(17 citation statements)

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“…The Takahata study is a population-based crosssectional study of Japanese people over 35 years old performed to clarify risk factors for certain lifestylerelated conditions, such as diabetes and obesity [23]. Takahata is an agricultural and suburban area about 300 km north of Tokyo.…”

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confidence: 99%

Association of the Common Fat Mass and Obesity Associated (FTO) Gene Polymorphism with Obesity in a Japanese Population

et al. 2010

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Obesity, which is a risk factor for various disorders including type 2 diabetes, hypertension, cancer, and cardiovascular disease, is one of the most common disorders in clinical practice worldwide and, thus, a global public health problem. It has been reported that the occurrence of obesity is determined by both environmental and genetic factors [1]. Increased energy intake and decreased physical activity are such envi- Abstract. The association of the FTO gene polymorphism, rs9939609, with obesity was examined using the population of the Takahata study (n (M/F): 2,639 (1,168 / 1,470); age: 63.0 ± 10.2 years), a Japanese community-based study. The effects of lifestyle-related factors, including nutritional intake and physical activities, on the association were also examined. Body mass index (BMI) was significantly associated with the FTO gene polymorphism (p<0.001). A case-control association study of the FTO gene polymorphism with obesity using multiple logistic regression analysis showed a significant association of the genotype AA (odds ratio, 1.53 [95% confidential interval, 1.04-2.24]) after adjustment for age and gender. Analysis to examine the differences in lifestyle-related factors among the genotype groups showed a significant difference in the energy expenditure for moderate to high-intensity physical activity (PA) (≥ 3.0 METs) (p=0.012) with a significant decrease toward the genotype AA (p=0.027). The effect of energy expenditure for moderate to high-intensity PA on the association of the polymorphism with obesity was then examined using study groups stratified based on the energy expenditure for moderate to high-intensity PA (Low-PA and High-PA). The BMI was significantly higher in the genotype AA in the Low-PA group (p=0.016) but not in the High-PA group (p=0.103). Furthermore, the genotype AA was significantly associated with obesity (odds ratio, 2.39 [95% confidential interval, 1.19-4.80]) in the Low-PA group but not in the High-PA group (p=0.650). The FTO gene, rs9939609, was associated with obesity, and the association was evident in subjects with low-PA, suggesting a PA-dependent association.

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Section: Subjectsmentioning

confidence: 99%

Association of the Common Fat Mass and Obesity Associated (FTO) Gene Polymorphism with Obesity in a Japanese Population

et al. 2010

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“…A total of six studies [23][24][25][26][27][28][29] were found. Of these, one [29] did not met our eligibility criteria (i.e.…”

Section: Characteristics Of the Participant Studiesmentioning

confidence: 99%

“…For the C1429T variant, data from up to 12259 participants from four studies (6,642 hypertensives and 5,633 normotensives; 3,581 overweight and 8,678 lean) were available [23,27,30,31]. For the odds of hypertension, controls subjects from the study by Suwazono et al [30].…”

Section: The C825t Polymorphism In Exon 10mentioning

confidence: 99%

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Multivariate meta-analysis of the association of G-protein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes

et al. 2014

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The objective of the present study was to review previous investigations on the association of haplotypes in the G-protein b3 subunit (GNB3) gene with representative cardiovascular risk factors/phenotypes: hypertension, overweight, and variation in the systolic and diastolic blood pressures (SBP and DBP, respectively) and as well as body mass index (BMI). A comprehensive literature search was undertaken in Pubmed, Web of Science, EMBASE, Biological Abstracts, LILACS and Google Scholar to identify potentially relevant articles published up to April 2011. Six genetic association studies encompassing 16,068 participants were identified. Individual participant data were obtained for all studies. The three most investigated GNB3 polymorphisms (G-350A, C825T and C1429T) were considered. Expectation-maximization and generalized linear models were employed to estimate haplotypic effects from data with uncertain phase while adjusting for covariates. Study-specific results were combined through a random-effects multivariate meta-analysis. After carefully adjustments for relevant confounding factors, our analysis failed to support a role for GNB3 haplotypes in any of the investigated phenotypes. Sensitivity analyses excluding studies violating Hardy-Weinberg expectations, considering gender-specific effects or more extreme phenotypes (e.g. obesity only) as well as a fixedeffects ''pooled'' analysis also did not disclose a significant influence of GNB3 haplotypes on cardiovascular phenotypes. We conclude that the previous cumulative evidence does not support the proposal that haplotypes formed by common GNB3 polymorphisms might contribute either to Electronic supplementary material The online version of this article

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“…The Takahata study is a population-based cross-sectional study of Japanese people ≥ 40 years old that was performed to determine risk factors for lifestyle-related conditions, including diabetes and obesity [18,19]. Takahata is an agricultural and suburban area about 300 km north of Tokyo.…”

Section: Subjectsmentioning

confidence: 99%

Lower physical activity is a risk factor for a clustering of metabolic risk factors in non-obese and obese Japanese subjects: The Takahata study

et al. 2013

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Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM

Cited by 22 publications

References 26 publications

Association of the Common Fat Mass and Obesity Associated (FTO) Gene Polymorphism with Obesity in a Japanese Population

Association of the Common Fat Mass and Obesity Associated (FTO) Gene Polymorphism with Obesity in a Japanese Population

Multivariate meta-analysis of the association of G-protein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes

Lower physical activity is a risk factor for a clustering of metabolic risk factors in non-obese and obese Japanese subjects: The Takahata study

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