Lower physical activity is a risk factor for a clustering of metabolic risk factors in non-obese and obese Japanese subjects: The Takahata study

Kaino, Wataru; Daimon, Makoto; Sasaki, Satoshi; Karasawa, Shigeru; Takase, Kaoru; Tada, Kyouko; Wada, Kiriko; Kameda, Wataru; Susa, Shinji; Oizumi, Toshihide; Fukao, Akira; Kayama, Takamasa; Kato, Takeshi

doi:10.1507/endocrj.ej12-0351

Cited by 8 publications

(5 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A large body of evidence has documented the beneficial effects of physical activity on the prevention of non-communicable diseases [ 1 – 3 ]. Epidemiological studies of total physical activity (TPA) related to daily living and work have reported dose-dependent health benefits, such as reductions in all-cause mortality, fatal and non-fatal cardiovascular disease, type 2 diabetes (T2D), and metabolic syndrome [ 4 – 7 ]. However, the underlying mechanisms by which TPA exerts these various health benefits are poorly understood [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men

et al. 2016

View full text Add to dashboard Cite

ObjectivePhysical activity is known to be preventive against various non-communicable diseases. We investigated the relationship between daily physical activity level and plasma metabolites using a targeted metabolomics approach in a population-based study.MethodsA total of 1,193 participants (male, aged 35 to 74 years) with fasting blood samples were selected from the baseline survey of a cohort study. Information on daily total physical activity, classified into four levels by quartile of metabolic equivalent scores, and sedentary behavior, defined as hours of sitting per day, was collected through a self-administered questionnaire. Plasma metabolite concentrations were quantified by capillary electrophoresis mass spectrometry method. We performed linear regression analysis models with multivariable adjustment and corrected p-values for multiple testing in the original population (n = 808). The robustness of the results was confirmed by replication analysis in a separate population (n = 385) created by random allocation.ResultsHigher levels of total physical activity were associated with various metabolite concentrations, including lower concentrations of amino acids and their derivatives, and higher concentrations of pipecolate (FDR p <0.05 in original population). The findings persisted after adjustment for age, body mass index, smoking, alcohol intake, and energy intake. Isoleucine, leucine, valine, 4-methyl-2-oxoisopentanoate, 2-oxoisopentanoate, alanine, and proline concentrations were lower with a shorter sitting time.ConclusionsPhysical activity is related to various plasma metabolites, including known biomarkers for future insulin resistance or type 2 diabetes. These metabolites might potentially play a key role in the protective effects of higher physical activity and/or less sedentary behavior on non-communicable diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The management of people with borderline anemia and polycythemia is an important topic in everyday medical care at the general internal medicine and hematological departments, but there are almost no studies that have focused on individuals with these conditions. The Takahata study is a large‐scale, population‐based study that includes the investigation into lifestyle habits, collects data related to diabetes and lipid metabolism, as well as hematological data, and conducts investigations related to adiponectin . It is considered that the prognosis and effects of adiponectin in those with borderline anemia and borderline polycythemia could be elucidated with this cohort study.…”

mentioning

confidence: 99%

Management of erythropoiesis: cross‐sectional study of the relationships between erythropoiesis and nutrition, physical features, and adiponectin in 3519 Japanese people

Kohno

Narimatsu

Shiono

et al. 2014

European J of Haematology

Self Cite

View full text Add to dashboard Cite

Although erythroid abnormalities (anemia and polycythemia) are commonly observed pathological conditions, not much information about borderline abnormalities is available. In this study, a cross-sectional study to analyze the relationships between erythropoiesis and nutrition, physical features, and laboratory test findings was conducted in middle-aged and older men and women. The study included 3519 Japanese people (1579 men and 1940 women), age 40 years and over. Analysis of variance showed that the group with a tendency to anemia was older, had a lower body mass index and diastolic blood pressure, and had higher serum adiponectin and creatinine. Multiple regression analysis showed that adiponectin, triglycerides, and total protein were common factors that affected erythropoiesis in both men and women. Hepatic, renal, and cardiac functions were also factors involved in erythropoiesis in men and in postmenopausal women. In addition, nutrient factors such as alcohol, vitamins, and carbohydrates were also significantly involved in erythropoiesis in men, but there were no significant nutrient factors involved in erythropoiesis in either premenopausal or postmenopausal women. This study showed that factors that influence erythropoiesis differ between men, premenopausal women, and postmenopausal women, and it suggested that appropriately modifying erythropoiesis management for each group of people is essential.

show abstract

“…We recently reported that alcohol intake by non-obese males with a clustering of MetRF was significantly higher than by those without, but such differnce was not observed in obese males [10]. Furthermore, analysis of non-obese males stratified into the four groups on the basis of alcohol consumption (none, light (1-139 g/ week), heavy (140-279 g/week), and very heavy (]280 g/ week)) revealed a positive linear association between amount of alcohol intake and clustering of MetRF [10], i.e., increasing alcohol intake seemed to increase the risk of clustering of MetRF among non-obese Japanese males whereas non-obese individuals with no or light alcohol consumption seemed to be at less risk. However, in the report by Hiraoka et al, even such individuals who were not obese, and who did not drink or were light drinkers, were shown to be more at risk if they had fatty liver [4].…”

mentioning

confidence: 82%

Lower physical activity is a risk factor for a clustering of metabolic risk factors in non-obese and obese Japanese subjects: The Takahata study

Cited by 8 publications

References 37 publications

Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men

Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men

Management of erythropoiesis: cross‐sectional study of the relationships between erythropoiesis and nutrition, physical features, and adiponectin in 3519 Japanese people

Is fatty liver indicative of a risk of metabolic syndrome among non-obese subjects?

Contact Info

Product

Resources

About