Management of erythropoiesis: cross‐sectional study of the relationships between erythropoiesis and nutrition, physical features, and adiponectin in 3519 Japanese people

Abstract

Although erythroid abnormalities (anemia and polycythemia) are commonly observed pathological conditions, not much information about borderline abnormalities is available. In this study, a cross-sectional study to analyze the relationships between erythropoiesis and nutrition, physical features, and laboratory test findings was conducted in middle-aged and older men and women. The study included 3519 Japanese people (1579 men and 1940 women), age 40 years and over. Analysis of variance showed that the group with a tendency to anemia was older, had a lower body mass index and diastolic blood pressure, and had higher serum adiponectin and creatinine. Multiple regression analysis showed that adiponectin, triglycerides, and total protein were common factors that affected erythropoiesis in both men and women. Hepatic, renal, and cardiac functions were also factors involved in erythropoiesis in men and in postmenopausal women. In addition, nutrient factors such as alcohol, vitamins, and carbohydrates were also significantly involved in erythropoiesis in men, but there were no significant nutrient factors involved in erythropoiesis in either premenopausal or postmenopausal women. This study showed that factors that influence erythropoiesis differ between men, premenopausal women, and postmenopausal women, and it suggested that appropriately modifying erythropoiesis management for each group of people is essential.

Predicting the emergence of anemia — A large cohort study

“…This is not the first reported observation of an association between total protein level and anemia. The finding that an elevated serum protein level is predictive of anemia in women is in accordance with the study by Kohno et al [25]. In their study, total protein was found to negatively affect erythropoiesis in both men and women.…”

“…shown to be involved in hematopoiesis [25]. In a recent cross-sectional study of 3519 Japanese subjects, low triglycerides and high total protein levels were significant factors that affected erythropoiesis [25]. In their study a negative correlation between triglycerides and adiponectin was shown.…”

“…Endocrine factors and lipid metabolism have been Table 3 Baseline laboratory parameters of the study population, according to appearance of anemia at the end of follow-up. shown to be involved in hematopoiesis [25]. In a recent cross-sectional study of 3519 Japanese subjects, low triglycerides and high total protein levels were significant factors that affected erythropoiesis [25].…”

High Serum Adiponectin Level Is a Risk Factor for Anemia in Japanese Men: A Prospective Observational Study of 1,029 Japanese Subjects

“…In a small-scale cohort study, high serum adiponectin levels were observed in postmenopausal women with mild anemia [9]. In addition, our previous large-scale cohort study of middle-aged and elderly individuals was the first to show that adiponectin, when highly expressed in serum, decrease red blood cell (RBC) counts in men as well as in women [10]. Recently, Lewerin et al reported that high adiponectin levels were associated with low blood hemoglobin (Hb) levels in elderly men in a large cohort study [11].…”

Effects of leptin and adinopectin on cardiovascular, respiratory and haematological systems of healthy dogs

“…A study suggests action of adiponectin on proliferation of hematopoietic stem cells by activating the receptor AdipoR1 in those cells (DIMASCIO et al, 2007). Moreover, studies of Matsubara et al (2004) and Kohno et al (2014) show a suppressive effect of adiponectin on bone marrow in vivo in humans. In this study, there was correlation between adiponectin and count of red blood cells and platelets suggesting a proliferative effect of adiponectin on hematopoiesis in healthy female dogs.…”