Salt and pH sensitive semi‐interpenetrating polyelectrolyte hydrogels poly(HEMA‐co‐METAC)/PEG and its BSA adsorption behavior

Abstract

A novel semi-interpenetrating poly(2-hydroxyethyl methacrylate) (pHEMA) based polyelectrolyte hydrogel [p(HEMA-co-METAC)/PEG] was prepared by copolymerizing HEMA with the cationic monomer 2-methacryloyloxyethyltrimethyl ammonium chloride (METAC) in the presence of polyethylene glycol (PEG) with different content and molecular weight (MW 4000 and 400). The chemical structure of the gels was confirmed by FT-IR spectroscopy, morphology study was performed by scanning electron microscope (SEM), thermal stability was revealed by thermogravimetric analysis (TGA), and the mechanical properties were determined by electronic universal testing machine. Swelling studies showed introduction of cationic monomer METAC led to high water content, and the obvious salt and pH sensitive properties were observed which proved the smart behavior of the semiinterpenetrating polymer networks (IPNs) gels. In addition, the effect of temperature and some important biological solution on swelling behavior were reported. Cytotoxicity test demonstrated that synthesized gels owned satisfactory cytocompatibility and were convenient for the application as biomaterials. Finally, the weak bovine serum albumin (BSA) adsorption on semi-IPNs by introducing METAC and controlling the content of PEG in gels demonstrated that they were of good protein resistance effect in biomedical applications.

Cationic Salecan-based hydrogels for release of 5-fluorouracil

“…When the pH of the solution was increased, the degree of ionization of semi-IPN gels reduced. 42 This would result in that the electrostatic repulsion between the chains of semi-IPN hydrogels decreased, restricting water absorption. In sum, equilibrium swelling studies clearly revealed that the developed hydrogels were able to respond to environmental pH, making them quite attractive to serve as pH-responsive drug delivery vehicles.…”

“…Therefore, the water molecules were easily squeezed out. 14,42 On the other hand, the osmotic pressure between interior hydrogel and external swelling solution was reinforced when the KCl concentration enhanced. In this case, water in the inside architecture of the hydrogel tended to diffuse out to the culture medium, causing reduction of water uptake ability.…”

“…), the strong electrostatic repulsion between -N + (CH 3 ) 3 and positively charged drug facilitated the release of 5-uorouracil. 42 (2) When the pH of the release media was increased to 7.4, the solubility of 5-uorouracil was decreased, restricting the liberation of 5-uorouracil. 6 Apart from the inuences of different pHs, it is also noticed in Fig.…”

Influence of High Strain Dynamic Loading on HEMA–DMAEMA Hydrogel Storage Modulus and Time Dependence

“…Hydrogels have been an integral part of the medical and engineering fields for over half a century and continue to be an area of intense investigation due to their ideal viscoelastic, hydrophilic, multifunctional, and adaptive properties, where they have been studied for drug delivery [1][2][3][4], environmental remediation via the removal of dyes and heavy metal ions [5], wound healing [6,7], tissue-engineered scaffolds [8][9][10], contact lenses [11][12][13], pH and biosensors [14][15][16], and spinal cord injectables for regeneration [17,18]. Hydroxyethyl methacrylate (HEMA) hydrogels are one of the most extensively studied hydrogels for biomedical and energy storage applications because of their biocompatibility (e.g., non-toxic, non-immunogenic, and tissue compatible) [19,20], stability (e.g., resistance to enzymatic degradation and hydrolysis by acid or alkaline solutions) [21], and physical transparency (facilitating visual monitoring of processes or encapsulated elements for drug delivery, tissue engineering, or biosensors) [22].…”

Nanocomposite hydrogels for selective removal of cationic dyes from aqueous solutions

“…Hydrogels are used as absorbing pads, disposable diapers, gel actuators , water blocking tapes , membrane separation, bio‐adhesive carriers , and controlled drug delivery systems . Hydrogels are also used in agriculture, removal of heavy metals , horticulture , protein adsorption , tissue engineering , etc.…”