Cationic Salecan-based hydrogels for release of 5-fluorouracil

Qi, Xiaoliang; Li, Junjian; Wei, Wei; Zuo, Gancheng; Su, Ting; Pan, Xin; Zhang, Jianfa

doi:10.1039/c7ra01052d

Cited by 58 publications

(30 citation statements)

References 48 publications

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“…The water content within the hydrogel network will then spread and shrink. This indicates that increasing salt concentration will accelerate the release of water molecules from the network polymer then reduced of swelling ratio that agree with study Xiaoliang et al [36].…”

Section: Effect Of Ionic Strength On the Release Of Drug In Vitrosupporting

confidence: 90%

Swelling Behavior of Poly (Aam_ma) Hydrogel Matrix and Study Effects Ph and Ionic Strength, Enforcement in Controlled Release System

Karam

Alzayd

2018

Int J App Pharm

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Objective: The objective of this study was to estimate the performance of Acrylamide-malice acid (AAM_MA) hydrogel preparatory by free radical polymerization to loading/release Atenolol and Ciprofloxacin drugs from aqueous solution to be used in a controlled release system.Methods: Free radical polymerization method has been used to prepare (AAM-MA) hydrogel. The prepared hydrogel was characterized by Fourier transform infrared (FTIR), Thermal Gravimetric Analysis/Derivative Thermal Gravimetric (TGA/DTG) and Field Emission Scanning Electron Microscopy (FE-SEM) techniques. The pH-dependent swelling behavior was investigated in addition to the effective ionic strength on adsorption and release system of the drug in vitro.Results: Results showed that the highest swelling ration in pH=7.4 and the same value of pH for the release of the drug. Thermal analysis test for prepared hydrogel showed good thermal stability. The hydrogel showed a negative effect with an increase saline contact Calcium carbonate appeared to have highly effect on releasing drugs from the polymeric network.Conclusion: Higher ability of poly (AAM-MA) hydrogel to act as a carrier for the Ciprofloxacin and Atenolol with highest swelling and releasing under following conditions: at pH 7.4, at temperature 37 °C and the effect of ionic strength (charge/ratio) which indicate that the smaller radius have less effect on release and the largest charge have negative effect on release ratio that attributed to cation formation inter and intra complex surface hydrogel.

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Section: Effect Of Ionic Strength On the Release Of Drug In Vitrosupporting

confidence: 90%

Swelling Behavior of Poly (Aam_ma) Hydrogel Matrix and Study Effects Ph and Ionic Strength, Enforcement in Controlled Release System

Karam

Alzayd

2018

Int J App Pharm

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“…In another microtube, the same Observation of hydrogel morphology was carried out by a scanning electron microscopy [18][19][20] (SEM, S-800, Hitachi). The lyophilized hydrogels were coated with an ultra-thin layer of gold/platinum by ion sputtering (E1010, Hitachi, Tokyo, Japan) before observing with SEM.…”

Section: Hydrogel Formation Morphology Observation and Gelation Timementioning

confidence: 99%

Enhanced tissue adhesiveness of injectable gelatin hydrogels through dual catalytic activity of horseradish peroxidase

et al. 2017

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Development of bioadhesives with tunable mechanical strength, high adhesiveness, biocompatibility, and injectability is greatly desirable in all surgeries to replace or complement the sutures and staples. Herein, the dual catalytic activity of horseradish peroxidase is exploited to in situ form the hydroxyphenyl propionic acid-gelatin/thiolated gelatin (GH/GS) adhesive hydrogels including two alternative crosslinks (phenol-phenol and disulfide bonds) with fast gelation (few seconds -several minutes) and improved physicochemical properties. Their elastic moduli increase from 6.7 to 10.3 kPa by adding GS polymer that leads to the better stability of GH/GS hydrogels than GH ones.GH/GS adhesive strength is respectively 6.5-fold and 15.8-fold higher than GH-only and fibrin glue that is due to additional disulfide linkages between hydrogels and tissues. Moreover, in vitro cell study with human dermal fibroblast showed the cell-compatibility of GH/GS hydrogels. Taken together, GH/GS hydrogels can be considered as promising potential adhesive materials for various biomedical applications. K E Y W O R D Sadhesives, biodegradability, gelatin, in situ forming hydrogels, thiomers

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“…One of the important parameters when designing a hydrogel-based, controlled delivery system for cartilage repair is its loading ability for the bioactive substance. The incorporation of the drug into the matrix can be performed by a swelling-diffusion process [ 42 ], as in our case. Drug retention can occur by physical or chemical immobilization in the polymeric network or through electrostatic interactions [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

García-Couce

Vernhes

Bada

et al. 2021

IJMS

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Hydrogels obtained from combining different polymers are an interesting strategy for developing controlled release system platforms and tissue engineering scaffolds. In this study, the applicability of sodium alginate-g-(QCL-co-HEMA) hydrogels for these biomedical applications was evaluated. Hydrogels were synthesized by free-radical polymerization using a different concentration of the components. The hydrogels were characterized by Fourier transform-infrared spectroscopy, scanning electron microscopy, and a swelling degree. Betamethasone release as well as the in vitro cytocompatibility with chondrocytes and fibroblast cells were also evaluated. Scanning electron microscopy confirmed the porous surface morphology of the hydrogels in all cases. The swelling percent was determined at a different pH and was observed to be pH-sensitive. The controlled release behavior of betamethasone from the matrices was investigated in PBS media (pH = 7.4) and the drug was released in a controlled manner for up to 8 h. Human chondrocytes and fibroblasts were cultured on the hydrogels. The MTS assay showed that almost all hydrogels are cytocompatibles and an increase of proliferation in both cell types after one week of incubation was observed by the Live/Dead® assay. These results demonstrate that these hydrogels are attractive materials for pharmaceutical and biomedical applications due to their characteristics, their release kinetics, and biocompatibility.

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Cationic Salecan-based hydrogels for release of 5-fluorouracil

Abstract: We designed novel Salecan-based hydrogels for controlled release of 5-fluorouracil.

Cited by 58 publications

References 48 publications

Swelling Behavior of Poly (Aam_ma) Hydrogel Matrix and Study Effects Ph and Ionic Strength, Enforcement in Controlled Release System

Swelling Behavior of Poly (Aam_ma) Hydrogel Matrix and Study Effects Ph and Ionic Strength, Enforcement in Controlled Release System

Enhanced tissue adhesiveness of injectable gelatin hydrogels through dual catalytic activity of horseradish peroxidase

Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

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