Salpingo-oophorectomy and the Risk of Ovarian, Fallopian Tube, and Peritoneal Cancers in Women With a <EMPH TYPE="ITAL">BRCA1</EMPH> or <EMPH TYPE="ITAL">BRCA2</EMPH> Mutation

Abstract

Oophorectomy is associated with reduced risk of ovarian and fallopian tube cancer in high-risk women, although there is a substantial residual risk for peritoneal cancer in BRCA1 and BRCA2 mutation carriers following prophylactic salpingo-oophorectomy.

Effects of false-positive cancer screenings and cancer worry on risk-reducing surgery among BRCA1/2 carriers.

“…It is interesting to note that parity, a factor often associated with risk-reducing surgical uptake, was not associated with surgical uptake for either RRSO or RRBM. This finding is consistent with findings from a cohort study examining risk-reducing surgery and cancer outcomes in BRCA1/2 -positive women (Finch et al, 2006), the potential effect of which may be due to overlap with age and partnered status.…”

Breast and ovarian cancer risk management in a French cohort of 158 women carrying a BRCA1 or BRCA2 germline mutation: patient choices and outcome

“…These cases emphasize the importance of identification of these women in the population, diagnosis of the cancer predisposition, patient information and personalized management. The rate of ovarian cancer discovered at the time of PSO in this cohort was 2.94 %, fairly similar to the rates reported by Finch [38] (2.24 %) and Laki [39] (4.5 %).…”

Effectiveness of Risk-Reducing Salpingo-Oophorectomy in Preventing Ovarian Cancer in a High-Risk French Canadian Population

“…In the study of Kauff et al, 25 the mean age for RRSO was 47.7 years. The same was observed in the study of Finch et al, 13 where the mean age of RRSO was 46.4 years. The only way to identify BRCA mutation carriers earlier is by a thorough familial history taking.…”

“…A multicentric cohort with 555 patients who underwent an RRSO showed an incidence of peritoneal carcinoma of 4.3% at 20 years after the surgery. 13 Although we had 8 patients with fallopian tube atypias, these could not be classified as in situ or invasive carcinoma, which is in disagreement with the literature that reported rates of in situ or invasive fallopian tube occult carcinoma ranging from 2% to 10% after RRSO. 14,15 Epithelial carcinomas arising in the tubal mucosa can present in 2 ways: The first is the classically described tumor that is confined largely to the tube and expands outward, with invasion of the muscularis.…”