Salmonelose septicêmica prolongada associada à esquistossomose: evolução do conhecimento e mecanismos imunopatogênicos

Muniz‐Junqueira, Maria Imaculada; Tosta, Carlos Eduardo; Prata, Áluízio

doi:10.1590/s0037-86822009000400015

Cited by 12 publications

(5 citation statements)

References 96 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These healed lesions may be totally asymptomatic, though secondary bacterial infection usually supervenes due to urological instrumentation, leading to chronic cystitis. In certain endemic areas, salmonella organisms are notorious causes of resistant secondary bacterial cystitis [4] , owing to the known symbiotic association between schistosomes and certain salmonella strains [5] .…”

Section: Fibrotic Lesionsmentioning

confidence: 99%

Urinary Schistosomiasis: Review

Barsoum

2013

Journal of Advanced Research

View full text Add to dashboard Cite

In this review, the clinical manifestations of urinary schistosomiasis are displayed from a pathogenetic perspective. According to the prevailing host’s immune response profile, urinary schistosomiasis may be broadly categorized into cell-mediated and immune-complex-mediated disorders. The former, usually due to Schistosoma haematobium infection, are attributed to the formation of granulomata along the entire urinary tract. As they heal with excessive fibrosis, they may lead to strictures, calcifications and urodynamic abnormalities. The main impact is lower urinary, the site of heaviest ovi-position. Secondary bacterial or viral infection is common, any may be incriminated in secondary stone formation of the development of bladder malignancy. Immune-complex mediated lesions are usually associated with hepatosplenic schistosomiasis due to Schistosoma mansoni infection. Circulating complexes composed of schistosomal gut antigens and different classes of immunoglobulins deposit in the kidneys leading to several patterns of glomerular pathology. The latter have been categorized under six classes based on the histological and immunofluorescence profile. These classes have been linked to respective clinical manifestations and depend on the stage of evolution of the host’s immune response, extent of associated hepatic fibrosis and co-infection with salmonella or hepatitis C. Secondary amyloidosis develops in 15% of such patients, representing a critical impairment of macrophage function. Conclusion: The wide clinicopathological spectrum of urinary schistosomiasis mirrors the evolution of the host’s immune response according to chronicity of infection, bacterial or viral co-infection and, in the case of glomerulonephritis, to the extent of hepatic co-morbidity.

show abstract

Section: Fibrotic Lesionsmentioning

confidence: 99%

Urinary Schistosomiasis: Review

Barsoum

2013

Journal of Advanced Research

View full text Add to dashboard Cite

show abstract

“…Another study demonstrated that the host’s commensal bacteria during infection by S. mansoni played an important role in the formation of intestinal granulomas and specific immune responses of schistosomiasis, which may influence the excretion of eggs ( Barnhill et al, 2011 ). There are a few case reports related to septicemia, which demonstrated the coinfection with gut bacteria and S. mansoni ( Muniz-Junqueira, Tosta & Prata, 2009 ; Barnhill et al, 2011 ; Hsiao et al, 2016 ). Once in circulation, these gut bacteria reach the adult worms of S. mansoni present in mesenteric veins and colonize the cecum of the parasite ( Muniz-Junqueira, Tosta & Prata, 2009 ).…”

Section: Schistosomiasismentioning

confidence: 99%

“…There are a few case reports related to septicemia, which demonstrated the coinfection with gut bacteria and S. mansoni ( Muniz-Junqueira, Tosta & Prata, 2009 ; Barnhill et al, 2011 ; Hsiao et al, 2016 ). Once in circulation, these gut bacteria reach the adult worms of S. mansoni present in mesenteric veins and colonize the cecum of the parasite ( Muniz-Junqueira, Tosta & Prata, 2009 ). The association of bacteria with S. mansoni enables prolonged bacterial infections, the development of antibiotics resistance, and the ineffective treatment of both infections ( Barnhill et al, 2011 ).…”

Section: Schistosomiasismentioning

confidence: 99%

Unbalanced relationships: insights into the interaction between gut microbiota, geohelminths, and schistosomiasis

Araújo

Sato

et al. 2022

PeerJ

View full text Add to dashboard Cite

Hosts and their microbiota and parasites have co-evolved in an adaptative relationship since ancient times. The interaction between parasites and intestinal bacteria in terms of the hosts’ health is currently a subject of great research interest. Therapeutic interventions can include manipulations of the structure of the intestinal microbiota, which have immunological interactions important for modulating the host’s immune system and for reducing inflammation. Most helminths are intestinal parasites; the intestinal environment provides complex interactions with other microorganisms in which internal and external factors can influence the composition of the intestinal microbiota. Moreover, helminths and intestinal microorganisms can modulate the host’s immune system either beneficially or harmfully. The immune response can be reduced due to co-infection, and bacteria from the intestinal microbiota can translocate to other organs. In this way, the treatment can be compromised, which, together with drug resistance by the parasites makes healing even more difficult. Thus, this work aimed to understand interactions between the microbiota and parasitic diseases caused by the most important geohelminths and schistosomiasis and the consequences of these associations.

show abstract

“…A study suggested that symbiotic bacteria in the host play a significant role in the formation of intestinal granulomas and the specific immune response during S. mansoni infection, which may impact the excretion of eggs. Cases of co-infection with intestinal bacteria and schistosomes have been reported, where intestinal bacteria, once in the bloodstream, can reach the adult schistosome worms residing in the mesenteric veins and establish colonization in the parasite's cecum [ 50 ]. The most frequently reported association is between Schistosoma and Salmonella infection, with most studies consistently finding that prior schistosome infections enhance and prolong subsequent Salmonella infection.…”

Section: Introductionmentioning

confidence: 99%

Advances in the study of the interaction between schistosome infections and the host's intestinal microorganisms

Hong,

Umar,

Chen

et al. 2024

Parasites Vectors

View full text Add to dashboard Cite

Schistosomiasis, also called bilharziasis, is a neglected tropical disease induced by schistosomes that infects hundreds of millions of people worldwide. In the life cycle of schistosomiasis, eggs are regarded as the main pathogenic factor, causing granuloma formation in the tissues and organs of hosts, which can cause severe gastrointestinal and liver granulomatous immune responses and irreversible fibrosis. Increasing evidence suggests that the gut microbiome influences the progression of schistosomiasis and plays a central role in liver disease via the gut–liver axis. When used as pharmaceutical supplements or adjunctive therapy, probiotics have shown promising results in preventing, mitigating, and even treating schistosomiasis. This review elucidates the potential mechanisms of this three-way parasite–host–microbiome interaction by summarizing schistosome-mediated intestinal flora disorders, local immune changes, and host metabolic changes, and elaborates the important role of the gut microbiome in liver disease after schistosome infection through the gut–liver axis. Understanding the mechanisms behind this interaction may aid in the discovery of probiotics as novel therapeutic targets and sustainable control strategies for schistosomiasis. Graphical Abstract

show abstract

Salmonelose septicêmica prolongada associada à esquistossomose: evolução do conhecimento e mecanismos imunopatogênicos

Cited by 12 publications

References 96 publications

Urinary Schistosomiasis: Review

Urinary Schistosomiasis: Review

Unbalanced relationships: insights into the interaction between gut microbiota, geohelminths, and schistosomiasis

Advances in the study of the interaction between schistosome infections and the host's intestinal microorganisms

Contact Info

Product

Resources

About