Salmonella meningitis and its complications in infants

Lee, Way Seah; Sd, Puthucheary; Omar, Amr S

doi:10.1046/j.1440-1754.1999.00387.x

Cited by 52 publications

(60 citation statements)

References 21 publications

(49 reference statements)

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“…CNS infection is present in approximately 0.1 to 0.9% of cases (167). CNS infection by NTS is primarily a disease of children, particularly neonates and infants (218,418). Only about 10 cases of Salmonella meningitis have been reported in adults (186,220).…”

Section: Salmonella Speciesmentioning

confidence: 99%

“…In this series, 69% of infants had seizures, 38% developed hydrocephalus, whereas subdural effusions and empyema were present in 31 and 23%, respectively. Overall mortality in the last 40 years has ranged from 0 to 59% (13,171,191,218,231,256). Neurological complications, including mental retardation, cerebral palsy, and visual and hearing impairment, have been found in 13 to 62% of survivors.…”

Section: Salmonella Speciesmentioning

confidence: 99%

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Invasion of the Central Nervous System by Intracellular Bacteria

2004

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Infection of the central nervous system (CNS) is a severe and frequently fatal event during the course of many diseases caused by microbes with predominantly intracellular life cycles. Examples of these include the facultative intracellular bacteria Listeria monocytogenes, Mycobacterium tuberculosis, and Brucella and Salmonella spp. and obligate intracellular microbes of the Rickettsiaceae family and Tropheryma whipplei. Unfortunately, the mechanisms used by intracellular bacterial pathogens to enter the CNS are less well known than those used by bacterial pathogens with an extracellular life cycle. The goal of this review is to elaborate on the means by which intracellular bacterial pathogens establish infection within the CNS. This review encompasses the clinical and pathological findings that pertain to the CNS infection in humans and includes experimental data from animal models that illuminate how these microbes enter the CNS. Recent experimental data showing that L. monocytogenes can invade the CNS by more than one mechanism make it a useful model for discussing the various routes for neuroinvasion used by intracellular bacterial pathogens

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Section: Salmonella Speciesmentioning

confidence: 99%

Section: Salmonella Speciesmentioning

confidence: 99%

Invasion of the Central Nervous System by Intracellular Bacteria

2004

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“…Intracranial infections due to Salmonella are rare complications of typhoid fever [1, 2, 5, 6, 8, 9, 10]. The infections are in the form of meningitis, subdural effusions and empyemas [4, 7, 8, 11, 12, 13, 14, 15, 16, 17], extradural empyema [1, 5, 6, 17], brain abscess and cerebral venous infarcts.…”

Section: Discussionmentioning

confidence: 99%

“…Surprisingly, however, focal intracranial pathology affecting the brain secondary to typhoid fever or salmonella infection is extremely rare, and only less than 80 cases have been reported in the world literature, including our cases [1, 2, 3, 4, 5, 6, 7]. Until the year 2000, only 35 cases of subdural empyema had been reported [1].…”

Section: Introductionmentioning

confidence: 96%

Intracranial Salmonella Infections: Meningitis, Subdural Collections and Brain Abscess

Mahapatra

Pawar²,

Sharma³

2002

Pediatr Neurosurg

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Focal intracranial infections due to Salmonella are rare. So far, around 80 cases have been reported in the world literature. The authors present their experience of 6 cases of intracranial Salmonella infections, mainly subdural empyema in 5 and effusion in 1. In 1 case, subdural empyema was bilateral, and in another case, there was an associated brain abscess. Positive blood cultures and positive Widal tests were noticed in 2 patients each. Early diagnosis and prompt evacuation of subdural collections and brain abscess and antibiotic therapy lead to satisfactory results. This study suggests that a high index of suspicion, early diagnosis and quick evacuation lead to success; this point is highlighted with the help of a review of the literature.

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“…In a study done in Kuala Lumpur by Lee et al on Salmonella meningitis in infants, 13 infants presented with fits and complications such as hydrocephalus, subdural effusions, empyema, ventriculitis, intracranial haemorrhage and cerebral abscess [4]. Overall mortality rate was 13%-18% [3,4].…”

Section: Salmonella Meningitismentioning

confidence: 98%