Salmonella enterica: un aliado en la terapia contra el cáncer

Abstract

Salmonella enterica, a species of facultative anaerobic bacteria, has demonstrated success as a live-attenuated bacterial vector for vaccination. S. enterica has also demonstrated promise as a therapeutic agent against cancer. Pre-clinical and clinical trials have shown that S. enterica is localized in both solid and semi-solid tumors as well as in metastatic tumors. Moreover, S. enterica reduces resistance to treatment with other agents. In this review we present the novel therapeutic anti-cancer approaches that use S. enterica both for its ability as a delivery system for heterologous moieties against cancer and for its direct anti-cancer properties.

Cancer Immunotherapy: Priming the Host Immune Response with Live Attenuated Salmonella enterica

“…Over a century and a half after the first reports on bacterial antitumor activity [ 7 , 130 ], live attenuated Salmonella enterica has been consolidated as an ally in cancer therapy [ 5 , 11 , 12 , 131 ]. However, although some clinical trials have been reported (Tables 1 and 2 ), their number should be increased with different malignant neoplasms using Salmonella enterica as an alternative antitumor therapy, including the possibility of using the bacterium in combination with chemotherapeutic agents [ 132 ].…”

“…In this context, the concept of using bacteria as agents against cancer described over a century ago [ 4 ] recently has generated great interest, as a result of the development of live attenuated bacterial vectors safe for human use, such as Salmonella enterica . This bacterium has proven usefulness in antitumoral therapy, by inducing innate and adaptive immune response in preclinical and clinical assays, which has led the tumor elimination without secondary effects [ 5 ], making Salmonella enterica a great candidate to cancer immunotherapy.…”

Nontyphoidal Salmonella : a potential anticancer agent

“…; Chavez‐Navarro et al . ; Zheng and Min ). A number of recent reviews have illustrated this role of Salmonella quite elaborately (Wang et al .…”

Salmonella Typhimurium as a potential anticancer agent: A Review

“…Among all these bacteria, S. Typhimurium has been the most extensively studied for its potential use in cancer therapy with varying degrees of success. [11][12][13][14][15] S. Typhimurium, a non-typhoidal Salmonella strain which is a Gram-negative, facultative anaerobic bacterium, is able to grow and replicate within the cells of it host. 16 S. Typhimurium can penetrate deep into tumours and are unaffected by the tumour's immune evasion strategies.…”

“…The choice of S. Typhimurium as a therapeutic alternative against cancer, 11,24 is due mainly to the ability of the bacterium to selectively colonize the tumour microenvironment. 25 S. Typhimurium is able to successfully penetrate and invade tumour tissue as they are drawn towards chemical compounds produced by cancer cells such as aspartate, serine, citrate, ribose or galactose, which serve as chemoattractants and preferentially grow within tumour tissues.…”