Nontyphoidal Salmonella : a potential anticancer agent

Abstract

Summary Use of bacteria in cancer therapy, despite being considered as a potent strategy, has not really picked up the way other methods of cancer therapies have evolved. However, in recent years, the interest on use of bacteria to kill cancer cells has renewed considerably. The standard and widely followed strategies of cancer treatment often fail either due to the complexity of tumour biology or because of the accompanying side effects. In contrast, these limitations can be easily overcome in a bacteria‐mediated approach. Salmonella is a bacterium, which is known for its ability to colonize solid or semisolid tumours more efficiently than any other bacteria. Among more than 2500 serovars of Salmonella, S. Typhimurium has been widely studied for its antagonistic effects on cancer cells. Here in, we review the current status of the preclinical and the clinical studies with a focus on the mechanisms that attribute the anticancer properties to nontyphoidal Salmonella.

The Microbiome and Cancer: Creating Friendly Neighborhoods and Removing the Foes Within

“…In addition, many facultative anaerobes including multiple strains of E. coli, Salmonella, Vibrio cholerae, and Shigella flexneri show favorable response in several cancer models (121)(122)(123)(124). Of note, Salmonella enterica serovar Typhimurium presents a unique advantage as it can grow in both aerobic and anaerobic conditions allowing its colonization in small nonhypoxic tumors, metastatic lesions, and multiple cell types including epithelial cells, macrophages, and dendritic cells making it most suitable for cancer therapeutics (125,126). Intriguingly, S. typhimurium administration inhibits metastatic progression in pancreatic (127) and prostate cancer (128).…”

Salmonella Typhimurium as a potential anticancer agent: A Review

“…This effect can be reduced by incorporating certain genetic manipulations in the organism to enhance its efficiency in tumour regression. 63 A Salmonella strain with a synchronized lysis circuit, mediated by a quorum-sensing lysis system, which permits the release of toxic substances in a wobbling manner into the tumour was developed. 64 This strain caused a notable reduction of tumour activity along with reduced cytotoxicity on normal cells.…”

Whole Genome Sequencing, Antibiotic Resistance, and Epidemiology Features of Nontyphoidal Salmonella Isolated From Diarrheic Children: Evidence From North China

“…So far, over 2,500 Salmonella enteric serovars have been recognized, and S. Enteritidis and S. Typhimurium are the most prevalent serotypes (Michael and Schwarz, 2016 ; Jazeela et al, 2020 ). In recent years, emerging Salmonella serovars, such as S .…”