Salivary secretory immunoglobulin A reactivity: a comparison to cortisol and -amylase patterns in the same breast cancer survivors

Lambert, Maude; Couture-Lalande, Marie-Ève; Brennan, Kelly; Basic, Aldin; Lebel, Sophie; Bielajew, Catherine

doi:10.5114/wo.2018.78946

Cited by 8 publications

(5 citation statements)

References 87 publications

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“…However, in their study, cortisol concentrations in the same participants were also elevated in tandem with alpha-amylase values. Typically, cortisol stress-induced reactions are delayed compared to that of alpha-amylase following TSST (Lambert et al, 2018). These findings corroborate other replications using the TSST paradigm in that sAA levels increased after a stressor and recovered within 10 minutes (Fischer et al, 2017;Nater et al, 2005Nater et al, , 2006.…”

Section: Stress System and Biomarkerssupporting

confidence: 86%

“…Paradigms used in this type of research usually involve an active and present threat such as tasks conducted in the TSST. The very few studies that have examined both biomarkers, cortisol and sAA, in the same subjects (Balodis et al, 2010;Lambert et al, 2018;Lucas et al, 2017) have used the TSST, the gold standard for producing a reliable physiological stress response. In each of these studies, elevations in both cortisol and sAA were observed.…”

Section: Discussionmentioning

confidence: 99%

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Outgroup threat and opportunity to derogate: A social neuroscience approach

2023

Psychology of Language and Communication

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Outgroup threat and opportunity to derogate:A social neuroscience approachIntergroup communication is at the core of intergroup relations. Studies demonstrate that intergroup threat and having an opportunity to derogate the outgroup result in heightened cortisol levels. However, biomarkers associated with different stress systems may show distinct patterns under the same conditions. We investigated whether perceptions of threat and the opportunity to derogate would result in an increase in alpha-amylase levels. White Canadian university students (N = 77) read discriminatory or favorable comments that Chinese individuals made towards Canadians. Subsequently, they were given the opportunity to derogate the outgroup. Salivary alpha-amylase was collected at baseline, following the threat, and after the opportunity to derogate. Participants showed an alpha-amylase response to threat, albeit delayed, but no further increase in concentration values due to derogation.The findings illustrate the impact of intergroup communication on physiological stress as well as the importance of using multiple biomarkers to elucidate that relationship.

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Section: Stress System and Biomarkerssupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Outgroup threat and opportunity to derogate: A social neuroscience approach

2023

Psychology of Language and Communication

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“…Cancer is associated with a change in a person’s life situation, which exposes the patient to significant stress during its course. This is confirmed by the results of Lambert et al, who, in their study on breast cancer survivors, describe disturbances in the secretion of cortisol in a group of oncological patients [ 56 ]. As proved by Sephton et al, dysregulation of cortisol secretion in cancer patients is also associated with impaired cell-mediated immunity [ 58 ].…”

Section: Discussionsupporting

confidence: 73%

“…However, in the stimulated saliva of Group II, a positive correlation was found between the level of cortisol and the cumulative dose of BPs. Cortisol is a steroid hormone secreted in response to stress [ 56 , 57 ]. Cancer is associated with a change in a person’s life situation, which exposes the patient to significant stress during its course.…”

Section: Discussionmentioning

confidence: 99%

A Study of Oral Health Parameters and the Properties and Composition of Saliva in Oncological Patients with and without Medication-Related Osteonecrosis of the Jaw Who Take Bisphosphonates

2023

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Background and Objectives: The aim of this study was to examine how the status of the oral cavity, composition and properties of saliva change in oncological patients with and without Medication-Related Osteonecrosis of the Jaw (MRONJ) undergoing bisphosphonate therapy. Materials and Methods: A retrospective case–control study of 49 oncological patients using bisphosphonates (BPs) was conducted. The study population was divided into two groups—Group I consisted of 29 patients with MRONJ and Group II of 20 patients without MRONJ. The control group consisted of 32 persons without oncological history and without antiresorptive therapy. Standard dental examination included the assessment of the number of teeth remaining, teeth with caries and fillings, Approximal Plaque Index (API) and Bleeding on Probing (BOP). In terms of MRONJ, localization and stage were assessed. Laboratory tests of saliva included determination of pH and concentrations of Ca and PO4 ions, total protein, lactoferrin, lysozyme, sIgA, IgA, cortisol, neopterin, activity of amylase at rest, and stimulated saliva. The buffering capacity and microbiological tests (Streptococcus mutans, Lactobacillus spp. load) of stimulated saliva were also determined. Results: There were no statistically significant differences between the selected oral parameters and saliva of Group I and Group II. Significant differences were found between Group I and the control group. BOP, lysozyme and cortisol concentration were higher, while the number of teeth with fillings, Ca and neopterin concentrations were lower in comparison to the control group. In Group I, a significantly higher percentage of patients with a high colony count (>105) of Streptococcus mutans and Lactobacillus spp. was also found. The significant differences between Group II and the control group concerned the concentrations of lysozyme, Ca ions, sIgA, neopterin and the colony count of Lactobacillus spp. In the Group I patients who received a significantly higher cumulative dose of BP compared to the Group II, a significant positive correlation was found between the received BP dose and the BOP. Most MRONJ foci were stage 2 and were mainly located in the mandible. Conclusions: Among oncological patients with and without MRONJ undergoing BP therapy compared to the control group, there are statistically significant differences in the dental, periodontal and microbiological status and in the composition of the saliva. Particularly noteworthy are the statistically significant differences in the decreased level of Ca ions, the increased level of cortisol and the elements of saliva related to the immune response (lysozyme, sIgA, neopterin). Additionally, a higher cumulative dose of BPs may affect the susceptibility to the development of osteonecrosis of the jaws. Patients undergoing antiresorptive therapy should receive multidisciplinary medical care, including dental care.

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“…There are no clear mechanisms to explain sIgA change in relation to pain. 64 In a study where pain intensity during CPT was measured, sIgA fell significantly after first exposure to CPT, but not after second exposure in the same participants’ other arm. There was no correlation with pain intensity.…”

Section: Resultsmentioning

confidence: 99%

Nociception related biomolecules in the adult human saliva: A scoping review with additional quantitative focus on cortisol

Zarnegar,

Vounta,

et al. 2024

Mol Pain

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Nociception related salivary biomolecules can be useful patients who are not able to self-report pain. We present the existing evidence on this topic using the PRISMA-ScR guidelines and a more focused analysis of cortisol change after cold pain induction using the direction of effect analysis combined with risk of bias analysis using ROBINS-I. Five data bases were searched systematically for articles on adults with acute pain secondary to disease, injury or experimentally induced pain. 43 articles met the inclusion criteria for the general review and 11 of these were included in the cortisol-cold pain analysis. Salivary melatonin, kallikreins, pro-inflammatory cytokines, soluable TNFαreceptor II, secretory IgA, testosterone, salivary α-amylase and, most commonly, cortisol have been studied in relation to acute pain. There is greatest information about cortisol and sAA which both rise after cold pain when compared with other modalities. Where participants have been subjected to both pain and stress, stress is consistently a more reliable predictor of salivary biomarker change than pain. In conclusion, there remain considerable challenges in identifying biomarkers that can be used in clinical practice to guide the measurement of nociception and treatment of pain. Standardization of methodology and researchers’ greater awareness of the factors that affect salivary biomolecule concentrations are needed to improve our understanding of this field towards creating a clinically relevant body of evidence.

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Salivary secretory immunoglobulin A reactivity: a comparison to cortisol and -amylase patterns in the same breast cancer survivors

Cited by 8 publications

References 87 publications

Outgroup threat and opportunity to derogate: A social neuroscience approach

Outgroup threat and opportunity to derogate: A social neuroscience approach

A Study of Oral Health Parameters and the Properties and Composition of Saliva in Oncological Patients with and without Medication-Related Osteonecrosis of the Jaw Who Take Bisphosphonates

Nociception related biomolecules in the adult human saliva: A scoping review with additional quantitative focus on cortisol

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