Salivary progesterone and cervical length measurement as predictors of spontaneous preterm birth

Maged, Ahmed M.; Mohesen, Mohamed N.; Elhalwagy, Ahmed; Abdelhafiz, Ali

doi:10.3109/14767058.2014.947474

Cited by 13 publications

(10 citation statements)

References 8 publications

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“…Progesterone is a key hormonal regulator of the female reproductive system and plays a major role in preparing the uterus for implantation and in the establishment and maintenance of pregnancy (32,33). PTB in women is associated with changes in circulating hormones such as progesterone deficits (34)(35)(36)(37)(38) or with inadequate responses to progesterone (32,39). To further demonstrate the effectiveness of bitter tastants in preventing PTB, we established another mouse model of preterm labor with the progesterone receptor antagonist RU-486.…”

Section: Bitter Tastant Chq Protects Against Mouse Ptbs Better Than Cmentioning

confidence: 99%

Bitter taste receptors as targets for tocolytics in preterm labor therapy

et al. 2017

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Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity, with few prevention and treatment options. Uterine contraction is a central feature of PTB, so gaining new insights into the mechanisms of this contraction and consequently identifying novel targets for tocolytics are essential for more successful management of PTB. Here we report that myometrial cells from human and mouse express bitter taste receptors (TAS2Rs) and their canonical signaling components ( G-protein gustducin and phospholipase C β2). Bitter tastants can completely relax myometrium precontracted by different uterotonics. In isolated single mouse myometrial cells, a phenotypical bitter tastant (chloroquine, ChQ) reverses the rise in intracellular Ca concentration ([Ca]) and cell shortening induced by uterotonics, and this reversal effect is inhibited by pertussis toxin and by genetic deletion of α-gustducin. In human myometrial cells, knockdown of TAS2R14 but not TAS2R10 inhibits ChQ's reversal effect on an oxytocin-induced rise in [Ca] Finally, ChQ prevents mouse PTBs induced by bacterial endotoxin LPS or progesterone receptor antagonist mifepristone more often than current commonly used tocolytics, and this prevention is largely lost in α-gustducin-knockout mice. Collectively, our results reveal that activation of the canonical TAS2R signaling system in myometrial cells produces profound relaxation of myometrium precontracted by a broad spectrum of contractile agonists, and that targeting TAS2Rs is an attractive approach to developing effective tocolytics for PTB management.-Zheng, K., Lu, P., Delpapa, E., Bellve, K., Deng, R., Condon, J. C., Fogarty, K., Lifshitz, L. M., Simas, T. A. M., Shi, F., ZhuGe, R. Bitter taste receptors as targets for tocolytics in preterm labor therapy.

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Section: Bitter Tastant Chq Protects Against Mouse Ptbs Better Than Cmentioning

confidence: 99%

Bitter taste receptors as targets for tocolytics in preterm labor therapy

et al. 2017

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“…Antenatal administration of progesterone prevents sPTB in women at increased risk . Low concentration of salivary progesterone was found to be associated with recurrent sPTB in a retrospective cohort of women at increased risk of sPTB, an observation that has been supported by more recent prospectively collected data . Historically HG is more common in multiple pregnancy where progesterone concentrations are higher.…”

Section: Introductionmentioning

confidence: 74%

Hospital admission for hyperemesis gravidarum in women at increased risk of spontaneous preterm birth

Kleine

Silva

Ahmed

et al. 2017

Birth

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BackgroundProgesterone administration prevents spontaneous preterm birth (sPTB) in women at increased risk. Progesterone concentration is lower in women with subsequent sPTB. Conversely, high concentrations of progesterone are implicated in the pathogenesis of hyperemesis gravidarum (HG). We hypothesized that women at increased risk of sPTB or spontaneous late miscarriage would be less likely to have a diagnosis of HG. To explore this hypothesis, we compared the incidence of HG in women at increased risk of sPTB and women with no identifiable risk factors.MethodsWomen at increased risk of sPTB were identified from a specialist Preterm Birth Clinic (PTBC) database where criteria for PTBC attendance are previous cervical surgery, previous sPTB <34 weeks, previous spontaneous late miscarriage, incidental sonographic cervical shortening, and uterine anomaly. Hospital antenatal booking and coding records for the same time period were examined to identify HG admissions. Women with multiple gestations, trophoblastic disease, or pre‐existing abnormal thyroid function were excluded. The incidence of HG among PTBC (n=394) and non‐PTBC attendees (n=4762) was calculated.ResultsThe incidence of HG was lower in women at increased risk of sPTB (1.52%, n=6) compared with women with no identifiable risk factor for sPTB (3.33%, n=159; P=.049).ConclusionHospital admission for HG is reduced in women with risk factors for sPTB compared with those without risk factors. Exploration of the pathogenesis of HG may improve understanding of the mechanisms underlying sPTB.

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“…1 Progesterone (P) is essential for the maintenance of pregnancy. 6 P level shows a limited variation during the first trimester of pregnancy and a single serum measurement of 25 ng/mL or more carries 97% likelihood for healthy pregnancy. 7 There is a rapid decline in P levels in most mammals before the onset of labor.…”

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confidence: 99%

The Effect of Antenatal Vaginal Progesterone Administration on Uterine, Umbilical, and Fetal Middle Cerebral Artery Doppler Flow: A Cohort Study

et al. 2019

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Objective This study aimed to evaluate the effect of vaginal progesterone (P) administration during the second and third trimesters of pregnancy on Doppler velocimetry of uterine, umbilical, and middle cerebral vessels. Study Design A prospective cohort study conducted on 80 women at risk for preterm labor. Uterine artery, umbilical artery, and middle cerebral artery (MCA) Doppler indices were measured before and after 1 week of administration of 200 mg twice daily vaginal P. The primary outcome parameter was the change of MCA pulsatility index (PI) after P administration. Secondary outcomes included changes in uterine artery and umbilical artery Doppler measurement. Results There was no significant changes of umbilical artery resistance index (RI) (0.69 ± 0.049 vs. 0.68 ± 0.041), umbilical artery PI (1.14 ± 0.118 vs. 1.11 ± 0.116), uterine artery RI (0.66 ± 0.12 vs. 0.66 ± 0.107), uterine artery PI (1.00 ± 0.26 vs. 1.016 ± 0.24), and MCA PI (1.27 ± 0.18 vs. 1.26 ± 0.23) measurements before and after 1 week of P administration, respectively. Conclusion Administration of vaginal P has no significant effects on uterine artery, umbilical artery, and MCA Doppler indices.

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Salivary progesterone and cervical length measurement as predictors of spontaneous preterm birth

Abstract: The measurement of both salivary progesterone and cervical length are good predictors for development of PTB.

Cited by 13 publications

References 8 publications

Bitter taste receptors as targets for tocolytics in preterm labor therapy

Bitter taste receptors as targets for tocolytics in preterm labor therapy

Hospital admission for hyperemesis gravidarum in women at increased risk of spontaneous preterm birth

The Effect of Antenatal Vaginal Progesterone Administration on Uterine, Umbilical, and Fetal Middle Cerebral Artery Doppler Flow: A Cohort Study

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