“…It was speculated that various growth factors were targets for these drugs, and their activation may be important in the pathogenesis of druginduced gingival overgrowth. 7 On the other hand, many studies [19][20][21][22][23][24][25][26] have investigated the relationship between the extent and severity of gingival overgrowth and drug variables, such as dose, duration, serum, and salivary concentrations. Gingival crevicular fluid (GCF) is a complex mixture of substances derived from serum, leukocytes, structural cells of the periodontium, and oral bacteria.…”