Salivary MMPs, TIMPs, and MPO levels in periodontal disease patients and controls

Meschiari, César A.; Marcaccini, Andrea M.; Moura, Bruna Cordeiro Santos de; Zuardi, Leonardo Raphael; Tanus‐Santos, José Eduardo; Gerlach, Raquel Fernanda

doi:10.1016/j.cca.2013.03.008

Cited by 46 publications

(50 citation statements)

References 45 publications

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“…Non-surgical periodontal treatment markedly improved all the clinical parameters in both groups (data were published elsewhere) [20]. Stimulated whole saliva had the highest nitrite concentration (Fig.…”

Section: Resultssupporting

confidence: 57%

“…Results obtained with this same cohort on how periodontal therapy affects inflammatory parameters as well as MMP-2, MMP-8, MMP-9, TIMP-1, TIMP-2, and myeloperoxidase in plasma, saliva, and crevicular fluid have been published elsewhere [16][17][18][19][20].…”

Section: Methodsmentioning

confidence: 99%

“…Patients were selected and were submitted to a non-surgical periodontal treatment as described by Marcaccini et al [20]. The subjects included in the PD group (n = 22) were submitted to a non-surgical periodontal treatment, which consisted of four sessions of scaling and root planning over a maximum of four weeks.…”

Section: Methodsmentioning

confidence: 99%

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Salivary, blood and plasma nitrite concentrations in periodontal patients and healthy individuals before and after periodontal treatment

Meschiari

Zuardi

Gomes

et al. 2015

Clinica Chimica Acta

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Section: Resultssupporting

confidence: 57%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Salivary, blood and plasma nitrite concentrations in periodontal patients and healthy individuals before and after periodontal treatment

Meschiari

Zuardi

Gomes

et al. 2015

Clinica Chimica Acta

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“…Componentes dos SPS, a PO e a MPO salivares foram amplamente estudados no DM (Güven et al, 1996;Wiersna et al, 2008;Gorudko et al, 2012) e na DP (Miyasaki;Nemirovskly;Gonçalves et al, 2008;Meschiari et al, 2013). Os resultados do presente estudo estão consistentes com os estudos de Smith et al (1984), Güven et al (1996), Sakamoto et al (2008) (Gonçalves et al, 2008).…”

Section: Resultados Demográficosunclassified

“…A PO e a MPO foram amplamente estudados na saliva no DM (Guven et al, 1996;Wiersna et al, 2008;Gorudko et al, 2012) e na DP (Miyasaki;Nemirovskiy, 1997;Gonçalves et al, 2008;Meschiari et al, 2013). Foi relatado um aumento da atividade SPO em gengivite experimental, uma vez que ocorre uma exsudação de leucócitos através do sulco gengival para a saliva, diminuindo sua atividade após higiene oral normal (Smith et al, 1984).…”

Section: Saliva E O Sistema Peroxidaseunclassified

Comportamento dos sistemas peroxidase e antioxidante, e produtos de peroxidação lipídica na saliva total de pacientes com diabetes mellitus 2 antes e após tratamento periodontal não cirúrgico

Takahashi¹

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Aos pacientes, muito obrigada pela participação e por confiarem neste estudo.Ao meu orientador Prof. Luiz Lima, primeiramente obrigada por ter me aceitado como orientada. Agradeço muito pela oportunidade de ter trabalhado ao seu lado, sempre aprendendo com seu conhecimento de altíssimo nível. Aprendi muito com a sua humildade, bondade e paciência para ensinar.Obrigada pelo apoio, por acreditar e confiar na minha capacidade.Ao meu orientador de iniciação científica Prof. Mário Taba Júnior da minha antiga casa FORP, quem me acolheu e me introduziu à periodontia. Saiba que o admiro muito e sou profundamente agradecida pelo que me ensinou.Ao Dr. Eduardo Sampaio e equipe de periodontia da APCD Vila Mariana. Agradeço por tudo que vocês me ensinaram, por terem feito parte da fase mais importante da minha carreira facilitando na minha decisão de seguir na área de periodontia.À Ana Paula Sassá Bendete... Sou eternamente grata a oportunidade que foi me dada em trabalhar com você. Aprendi muito com a sua paciência, inteligência e bondade.Obrigada pelo acolhimento que você e o prof. Luiz me proporcionaram nessa linha de pesquisa tão linda que acabei me apaixonando. Quando entrei na pesquisa não sabia que ia encontrar alguém que fosse ser importante na minha vida, uma AMIGA. Foi muito gratificante conhecer você e sua linda família!!! Ao meu namorado Willian N. Kaneko agradeço do fundo do coração pelas palavras de conforto nas horas de desabafo e tensão, e pelos conselhos durante toda essa jornada.Obrigada pela compreensão, pelo apoio e principalmente pela paciência nesses últimos anos que significaram tanto na minha vida. Te amo muito! Ao Rafael Takahashi, Letícia Kimura, Thainah, Rafaela e Caroline Kaneko Ishii, Kimiyo e Sérgio Kaneko. Obrigada por todo apoio e por terem tornado essa jornada mais leve e divertida. were submitted to NSPT, and those with periodontal health (DM and C) received oral hygiene instructions and prophilaxys only. Results: At baseline, DMPC and PC patients showed PD, BOP, PI and CAL higher levels when compared to DM and C groups (p<0.05). After NSPT, all these clinical parameters had significant improvement (p<0.05) in both groups. HbA1c medians were significantly higher in DMPC when compared to DM, at baseline, however, the NSPT did not improved after 1 and 3 months of glicemic control, though percentual reduction (0.4%) observed at clinical point of view might be considered important. As to laboratorial analysis, in DMPC group, TBARS levels were significantly decreased compared to DM, PC and C (p<0.05), and SPO activity were significantly higher than PC and C (p<0.05), with negative correlation between TBARS and SPO (r=-0.35; p=0.002), while TAS levels and SOD activity did not show any significant differences among studied groups (p>0.05). After NSPT, TBARS levels increased significantly, and SPO decreased significantly only in DMPC group (p<0.05 and p<0.05), whereas SOD and TAS values remained unchanged in DMPC and PC groups. Conclusion: At baseline, TBARS levels and SPO activity have been altere...

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Assessing salivary matrix metalloproteinase‐8 in prostate cancer patients undergoing androgen deprivation therapy

Memon

Aleem

Memon

et al. 2022

Clinical & Exp Dental Res

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Introduction Matrix metalloproteinase‐8 (MMP‐8) is considered as one of the most promising diagnostic markers for periodontal disease. Androgen deprivation therapy (ADT) has been correlated with impaired collagen synthesis and an increase in periodontal tissue susceptibility to pathogenic microorganisms. Objective This study aims to investigate the impact of ADT on salivary MMP‐8 level and periodontal parameters, which might be useful in monitoring periodontal disease in prostate cancer patients undergoing ADT. Materials and Methods A total of 88 subjects were selected and were divided into two groups: Group I included n = 78 PC patients who have been undergoing ADT); Group II included n = 10 healthy individuals. Periodontal parameters such as plaque index (PI), gingival index (GI), periodontal probing depth (PPD), and clinical attachment level (CAL) were examined. The salivary MMP‐8 level was estimated by using the sandwich enzyme‐linked immunosorbent assay method. Results Significant differences in mean salivary MMP‐8 level were found between PC patients undergoing ADT and healthy individuals. Salivary MMP‐8 levels of all individuals were positively correlated with GI, PI, PPD, and CAL. Salivary MMP‐8 can distinguish between periodontitis and healthy individuals with an accuracy of about 80%. Conclusion Salivary MMP‐8 levels were found to be higher in prostate cancer patients undergoing ADT compared to healthy individuals.

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Salivary MMPs, TIMPs, and MPO levels in periodontal disease patients and controls

Cited by 46 publications

References 45 publications

Salivary, blood and plasma nitrite concentrations in periodontal patients and healthy individuals before and after periodontal treatment

Salivary, blood and plasma nitrite concentrations in periodontal patients and healthy individuals before and after periodontal treatment

Comportamento dos sistemas peroxidase e antioxidante, e produtos de peroxidação lipídica na saliva total de pacientes com diabetes mellitus 2 antes e após tratamento periodontal não cirúrgico

Assessing salivary matrix metalloproteinase‐8 in prostate cancer patients undergoing androgen deprivation therapy

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