Salivary macrophage activation‐related chemokines and mitogen‐activated kinase kinase‐degrading proteolytic activity in type 1 diabetes mellitus

Yilmaz, Neslihan; Polat, Reyhan; Gürsoy, Mervi; Kaman, Wendy E.; Aydin, Elif Gül; Fteita, Dareen; Yılmaz, Doğukan; Bikker, Floris J.; Gürsoy, Ulvi Kahraman

doi:10.1002/jper.22-0314

Cited by 4 publications

(3 citation statements)

References 50 publications

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“…Furthermore, a case-control study revealed increased salivary IL-17 levels in diabetic children, highlighting potential immune dysregulation in T1DM (del Valle et al, 2015). Additionally, Yilmaz et al (2023) demonstrated altered salivary concentrations of macrophage activation-related chemokines and MAPKK-degrading proteolytic activity in T1DM patients showing higher levels of monokine induced by interferon gamma (MIG) and macrophage inflammatory protein-1 alpha (MIP-1α) in saliva of T1DM patients, underscoring the impact of T1DM on the host immune response (Yilmaz et al, 2023).…”

Section: Host Immune Markersmentioning

confidence: 99%

Investigating the Interplay: Periodontal Disease and Type 1 Diabetes Mellitus - A Comprehensive Review of Clinical Studies

Vlachou,

Loume,

Giannopoulou

et al. 2024

Preprint

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Diabetes mellitus (DM) poses a significant challenge to global health, with its prevalence projected to rise dramatically by 2045. This narrative review explores the bidirectional relationship between periodontitis (PD) and type 1 diabetes mellitus (T1DM), focusing on cellular and molecular mechanisms derived by the interplay between oral microbiota and the host immune response. A comprehensive search of literature published between 2008 and 2023 was conducted to elucidate the association between these two diseases. Preclinical and clinical evidence suggests a bidirectional relationship, with individuals with T1DM exhibiting heightened susceptibility to periodontitis, and vice versa. The review includes recent findings from human clinical studies, revealing variations in oral microbiota composition in T1DM patients, including increases in certain pathogenic species such as Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans, along with shifts in microbial diversity and abundance. Molecular mechanisms underlying this association involve oxidative stress and dysregulated host immune responses, mediated by inflammatory cytokines such as IL-6, IL-8, and MMPs. Furthermore, disruptions in bone turnover markers, such as RANKL and OPG, contribute to periodontal complications in T1DM patients. While preventive measures to manage periodontal complications in T1DM patients may improve overall health outcomes, further research is needed to understand the intricate interactions between oral microbiota, host response, periodontal disease, and systemic health in this population.

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Section: Host Immune Markersmentioning

confidence: 99%

Investigating the Interplay: Periodontal Disease and Type 1 Diabetes Mellitus - A Comprehensive Review of Clinical Studies

Vlachou,

Loume,

Giannopoulou

et al. 2024

Preprint

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“…Cytokine analysis was performed as previously described [24,25]. In brief, saliva samples were thawed and centrifuged at 9300× g for 5 min at room temperature.…”

Section: Cytokine Analysismentioning

confidence: 99%

Probiotics Partly Suppress the Impact of Sugar Stress on the Oral Microbiota—A Randomized, Double-Blinded, Placebo-Controlled Trial

Lundtorp Olsen,

Massarenti,

Vendius

et al. 2023

Nutrients

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The aim was to test if probiotics counteract oral dysbiosis during 14 days of sugar stress and subsequently help restore oral homeostasis. Eighty healthy individuals received either probiotics (n = 40) or placebo lozenges (n = 40) for 28 days and rinsed with a 10% sucrose solution 6–8 times during the initial 14 days of the trial. Saliva and supragingival samples were collected at baseline, day 14, and day 28. Saliva samples were analyzed for levels of pro-inflammatory cytokines, albumin, and salivary enzyme activity. The supragingival microbiota was characterized according to the Human Oral Microbiome Database. After 14 days of sugar stress, the relative abundance of Porphyromonas species was significantly higher (p = 0.03) and remained significantly elevated at day 28 in the probiotic group compared to the placebo group (p = 0.004). At day 28, the relative abundance of Kingella species was significantly higher in the probiotic group (p = 0.03). Streptococcus gordinii and Neisseria elongata were associated with the probiotic group on day 28, while Streptococcus sobrinus was associated with the placebo group on day 14 and day 28. On day 28, the salivary albumin level was significantly lower in the probiotic group. The present study demonstrates a potential stabilizing effect on the supragingival microbiota mediated by consumption of probiotics during short-term sugar stress.

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“…Salivary levels of interleukin (IL)-1β, IL-8, monocyte chemoattractant protein-1 (MCP-1), and macrophage migration inhibitory factor (MIF) were measured as previously described [15,16]. In brief, salivary samples were centrifuged at 9300× g for 10 min at room temperature.…”

Section: Cytokine Analysismentioning

confidence: 99%

Probiotics Support Resilience of the Oral Microbiota during Resolution after Experimental Gingivitis—A Randomized, Double-Blinded, Placebo-Controlled Trial

Lundtorp Olsen,

Massarenti,

Vendius

et al. 2023

Nutrients

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The present study aims to test whether probiotics protect against experimental gingivitis incited by 14 days of oral hygiene neglect and/or subsequently support the restoration of oral homeostasis. Eighty systemically and orally healthy participants refrained from oral hygiene procedures for 14 days, followed by 14 days with regular oral hygiene procedures. Additionally, participants consumed either probiotics (n = 40) or placebo (n = 40) throughout the trial. At baseline, day 14, and day 28, supragingival plaque score and bleeding-on-probing percentage (BOP %) were registered, and supragingival plaque and saliva samples were collected. The supragingival microbiota was characterized using 16S sequencing, and saliva samples were analyzed for levels of pro-inflammatory cytokines and proteases. At day 28, the relative abundance of Lautropia (p = 0.014), Prevotella (p = 0.046), Fusobacterium (p = 0.033), and Selenomonas (p = 0.0078) genera were significantly higher in the placebo group compared to the probiotics group, while the relative abundance of Rothia (p = 0.047) species was associated with the probiotics group. Streptococcus sanguinis was associated with the probiotics group, while Campylobacter gracilis was associated with the placebo group. No difference was observed in salivary cytokines, albumin, or any enzyme activity. The present study suggests that probiotics support the resilience of the oral microbiota in the resolution period after gingivitis.

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Salivary macrophage activation‐related chemokines and mitogen‐activated kinase kinase‐degrading proteolytic activity in type 1 diabetes mellitus

Cited by 4 publications

References 50 publications

Investigating the Interplay: Periodontal Disease and Type 1 Diabetes Mellitus - A Comprehensive Review of Clinical Studies

Investigating the Interplay: Periodontal Disease and Type 1 Diabetes Mellitus - A Comprehensive Review of Clinical Studies

Probiotics Partly Suppress the Impact of Sugar Stress on the Oral Microbiota—A Randomized, Double-Blinded, Placebo-Controlled Trial

Probiotics Support Resilience of the Oral Microbiota during Resolution after Experimental Gingivitis—A Randomized, Double-Blinded, Placebo-Controlled Trial

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