Salivary immunoglobulin A in rheumatoid arthritis (RA) with focus on dental caries: a cross-sectional study

Chopra, Meheriar; Jadhav, Sameer; Venugopalan, Anuradha; Hegde, Vivek; Chopra, Arvind

doi:10.1007/s10067-011-1796-0

Cited by 8 publications

(3 citation statements)

References 20 publications

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“…Furthermore, patients with RA have repeatedly shown xerostomia [ 7 ], which is an important risk factor for caries, as it reduces the potential of remineralization [ 6 ]. Additionally, a case–control study investigated salivary immunoglobulin A in RA patients and controls without finding a statistical significance between those two groups [ 37 ]. Altogether, the quantity and quality of saliva appears to affect caries in individuals with RA.…”

Section: Discussionmentioning

confidence: 99%

Dental Caries in Adult Patients with Rheumatoid Arthritis—A Systematic Review

Kreher

Ernst

Ziebolz

et al. 2023

JCM

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Patients suffering from rheumatoid arthritis (RA) are repeatedly affected by oral diseases or complaints, including xerostomia, periodontitis and dental caries. The aim of this systematic review was the evaluation of caries prevalence and/or incidence in patients with RA. Within this review, there is a systematic search of the literature based on PubMed, Web of Science and Scopus. Two independent researchers performed the search in February 2023. The search terms were “dental caries” AND “rheumatoid arthritis”. Additionally, a manual search completed the review process. Studies on adult patients (age ≥ 18 years) only suffering from RA were included. Studies had to explicitly report on the prevalence or incidence of dental caries. The respective studies were checked regarding suitability and, if they were eligible, analyzed qualitatively. A quality appraisal was performed for all of the analyzed studies. A total of 336 studies were detected, of which 16 studies met the in- and exclusion criteria. The sample sizes of the clinical investigations ranged between 13 and 1337 participants. Twelve studies evaluated a healthy control group. In 8/12 studies, a significant difference in the prevalence/incidence of caries was found between RA patients and controls. The majority of the studies applied the decayed (DT), missing and filled teeth index (DMFT) for the diagnosis of caries. On average (mean value), 0.8 to 5.79 carious teeth per patient were reported across the studies. There was no information on the stadium, activity or location of caries (e.g., root caries) in any study. Quality appraisal revealed a moderate quality for most studies. In conclusion, caries prevalence was heterogeneous across studies, while a higher caries prevalence was repeatedly reported in RA patients against controls. Further research regarding dental caries in RA appears recommendable; multidisciplinary, patient-centered dental care for patients with RA should be fostered to improve patients’ dental health status.

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Section: Discussionmentioning

confidence: 99%

Dental Caries in Adult Patients with Rheumatoid Arthritis—A Systematic Review

Kreher

Ernst

Ziebolz

et al. 2023

JCM

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“…An AUC over 80% would, nevertheless, allow the salivary test to be considered as a screening test. The use of saliva as a diagnostic fluid has already been studied in coeliac disease,[ 22 ] dental caries,[ 23 ] familial juvenile SLE,[ 17 ] and diabetes. [ 24 ]…”

Section: Discussionmentioning

confidence: 99%

Salivary anti-cyclic citrullinated peptide as a screening tool for rheumatoid arthritis

et al. 2022

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Objectives: This study aims to evaluate the sensitivity and specificity of salivary anti-cyclic citrullinated peptide 3 (anti-CCP3) for the early diagnosis of rheumatoid arthritis. Patients and methods: Between June 2017 and April 2019, a total of 63 patients with rheumatoid arthritis (10 males, 53 females; mean age: 50.4±9.5 years; range, 27 to 74 years) and 49 healthy controls (8 males, 41 females; mean age: 49.3±9.3 years; range 27 to 67 years) were included. Salivary samples were collected by passive drooling. Anti-cyclic citrullinated peptide analyses of salivary and serum samples were performed. Results: The mean polyclonal immunoglobulin (Ig)G-IgA anti-CCP3 salivary levels were significantly different in patients (149.2±134.2) compared to healthy controls (28.5±23.9). The mean polyclonal IgG-IgA anti-CCP3 serum levels were measured as 254.0±169.5 in patients and 3.8±3.6 in healthy individuals. The diagnostic accuracy analysis of salivary IgG-IgA anti-CCP3 results in an area under the curve (AUC) of 0.818, as well as 91.84% specificity and 61.90% sensitivity. Conclusion: Salivary anti-CCP3 may be considered as an additional screening test for rheumatoid arthritis.

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“…Chopra 2011 [26] Unstimulated saliva 09:00-11:00(a.m.) Farias 2003 [28] Unstimulated saliva 08:00-11:00(a.m.)…”

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confidence: 99%

Association between salivary s-IgA concentration and dental caries: an updated meta-analysis

Gong

Wang

et al. 2020

Bioscience Reports

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Objective: To determine the levels of s-IgA in saliva of caries patients and healthy controls, and to evaluate whether there is a correlation between it and caries by meta-analysis. Methods: The PubMed, MEDLINE, EMBASE, Web of Science, Cochrane Library, Scopus, Chinese National Knowledge Infrastructure, Wanfang Data, Chongqing VIP database for Chinese Technical Periodicals, and China BioMedical Literature Services System databases were searched initially in April 2020 and repeated in August 2020. Two independent evaluators screened the literature and extracted the data according to the inclusion and exclusion criteria. R 4.0.2 software was used for meta-analysis. I2 test was commonly reflected the heterogeneity. Subgroup analysis and meta-regression analysis explore the sources of heterogeneity. Sensitivity analysis, funnel diagram, Begg’s rank correlation, and Egger’s linear regression were used to determine the possibility of publication bias. Results: The study was reviewed according to the project guidelines for optimal reporting (PRISMA) based on meta-analysis. A total of 30 case–control studies were included, with a total sample size of 1545 patients, including 918 caries patients and 627 healthy controls. Salivary s-IgA levels in caries patients were significantly lower than those in healthy controls (SMD = −0.49, 95%CI: [−0.94; −0.03], P=0.03). In addition, the results of subgroup analysis showed that the significant decrease of salivary s-IgA level was correlated with children patients, mixed dentition and Asian people (children: SMD = −0.45, 95%CI: [−0.89; −0.01], P=0.04; mixed dentition: SMD = −0.61, 95%CI: [−1.24; 0.03], P=0.06; Asian: SMD = −0.62, 95%CI: [−1.17; −0.08], P=0.02). The funnel diagram included in the study was symmetrically distributed, and the sensitivity analysis confirmed the robustness of the results. Conclusion: Salivary s-IgA levels in caries patients were significantly lower than in healthy controls. It has also been demonstrated that salivary s-IgA may be used as an alternative measure to identify subjects at risk of caries susceptibility, suggesting that salivary s-IgA may be a protective factor for dental caries.

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Salivary immunoglobulin A in rheumatoid arthritis (RA) with focus on dental caries: a cross-sectional study

Cited by 8 publications

References 20 publications

Dental Caries in Adult Patients with Rheumatoid Arthritis—A Systematic Review

Dental Caries in Adult Patients with Rheumatoid Arthritis—A Systematic Review

Salivary anti-cyclic citrullinated peptide as a screening tool for rheumatoid arthritis

Association between salivary s-IgA concentration and dental caries: an updated meta-analysis

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