Salivary IgA concentration in diabetic patients compared to healthy controls

Sardari, Farimah; Tahmasbi, A; Ghanbarzadegan, A

doi:10.4103/2155-8213.158478

Cited by 6 publications

(4 citation statements)

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“…Regarding IgA levels, our findings coincide with previous studies where T2DM was positively correlated to IgA and increased IgA concentrations were associated with hyperglycemia [40]. However, in another study, levels of salivary IgA in type II diabetic patients compared to their healthy controls did not show any significant difference [41].…”

Section: Discussionsupporting

confidence: 91%

Functional and histological evaluation of bone marrow stem cell-derived exosomes therapy on the submandibular salivary gland of diabetic Albino rats through TGFβ/ Smad3 signaling pathway

AbuBakr¹,

Haggag²,

Sabry³

et al. 2020

Heliyon

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Section: Discussionsupporting

confidence: 91%

Functional and histological evaluation of bone marrow stem cell-derived exosomes therapy on the submandibular salivary gland of diabetic Albino rats through TGFβ/ Smad3 signaling pathway

AbuBakr¹,

Haggag²,

Sabry³

et al. 2020

Heliyon

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“…[ 35 ] There was no significant difference between the T2D patients and the healthy controls in salivary s. IgA level and three studies showed agreement with this result. [ 3 17 18 ] The s. IgA level was higher[ 5 14 ] and lower[ 32 ] in the T2D patients than the controls in other studies. Therefore, the presence of Candida species and humoral response of the immune system to this microorganism, or compensatory mechanisms in the immune system can lead to enhanced humoral response and salivary IgA level.…”

Section: Discussionmentioning

confidence: 84%

“…The studies were published from 1996 to 2017. Two studies were reported in Turkey,[ 14 15 ] one in Pakistan,[ 16 ] three in Iran,[ 3 17 18 ] thirteen in India,[ 4 6 9 19 20 21 22 23 24 25 26 27 28 ] one in Brazil,[ 29 ] two in Nigeria,[ 30 31 ] one in Egypt,[ 5 ] one in Poland,[ 32 ] and one in China. [ 33 ] There were 1432 and 900 diabetic patients and healthy controls in all studies, respectively.…”

Section: Resultsmentioning

confidence: 99%

Effect of diabetes mellitus type 2 on salivary glucose, immunoglobulin A, total protein, and amylase levels in adults: A systematic review and meta-analysis of case–control studies

2018

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Background:Saliva is a fluid with the complex compound which can be used as diagnostic markers for type 2 diabetes (T2D). This meta-analysis evaluated salivary glucose, immunoglobulin A (IgA), total protein, and amylase levels in adult T2D compared with the controls as well as the correlation of salivary glucose levels with serum glucose and hemoglobin A1C (HbA1c) levels in both groups.Materials and Methods:Web of Science, Scopus, PubMed, and Cochrane Library databases were searched up to July 2017. A random-effects analysis was performed using the mean difference (MD) and 95% confidence intervals. The search terms were “T2D, IgA, amylase, total protein, or glucose” combination with “saliva.” The studied variables were the sample size, the percentage of male, the mean age, the condition of saliva sampling, and the salivary levels of mentioned factors.Results:A total of 25 studies were included in this meta-analysis with 1432 and 900 diabetic patients and healthy controls, respectively. MD of salivary glucose level in patients with T2D, compared with the healthy controls, in fasting and nonfasting conditions were 6.23 mg/dL (P = 0.0002) and 6.70 mg/dL (P < 0.00001), respectively. Furthermore, the fasting salivary total protein in the patients was significantly higher than the controls (MD = 167.96 mg/dL; P = 0.03). Non-fasting salivary amylase and secretory IgA levels were significantly lower in the patients (MD = −48.61 IU/mL; P < 0.00001) than in the controls (MD = −9.42 IU/mL; P = 0.0006), respectively. The pooled estimate showed a significant correlation between salivary and serum glucose in the patients (r = 0.765; P < 0.001) and the controls (r = 0.646; P < 0.001) and between salivary glucose and serum glycated hemoglobin in the patients (r = 0.721; P < 0.001).Conclusion:Measurement of these salivary factors can be helpful for diagnostic and monitoring purposes of T2D. In addition, salivary glucose as a diagnostic tool can evaluate serum glucose and HbA1c levels in the diabetic patients.

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“…Pada kondisi gingivitis dan periodontitis terdapat peningkatan kadar IgA saliva dengan subjek gingivitis yang memiliki kadar IgA yang lebih tinggi 21 . Pada kondisi sistemik seperti diabetes memiliki kadar IgA yang lebih tinggi dengan diabetes tipe I memiliki kadar IgA yang lebih tinggi daripada diabetes tipe II 22 . Aktivitas fisik seperti olahraga dengan intensitas sedang dan berat dapat menurunkan kadar IgA saliva 23,24 .…”

Section: Pembahasanunclassified

PENGARUH BERKUMUR DENGAN LARUTAN PROBIOTIK TERHADAP KADAR IgA DALAM SALIVA

Indraswary

Nurenda²,

Faturrahman³

2021

MoH

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ABSTRACT Saliva contains IgA which acted as the first line of defense against a pathogen in the oral cavity. IgA salivary in the elderly have decreased which caused prone to oral infection. The alternative way to increased salivary IgA levels was by gargling a probiotic solution. Gargling was a mechanical stimulation to increase the flow rate of saliva. Probiotic contains bacteria which can give advantage for the human body. Probiotics can stimulate the immune system to increased IgA levels. The purpose of this study was to determine the effect of gargling probiotic solutions on salivary IgA levels in the elderly. This study used a quasi-experimental pre and post-test design group. The number of samples was 11 people. Each sample was instructed to gargling probiotic solution 10 ml every morning and evening along with their saliva was taken before and after gargle the probiotic solution. Data analysis was done using a paired t-test. The result showed the mean of salivary IgA levels before gargling probiotic solution were 206.6818±25.17419 and salivary IgA levels after gargling probiotic solution were 223.4091±12.52042. Based on the paired t-test got a value of p=0.059 (>0.05) means there is no significant difference. The conclusion of this study was gargling probiotic solution can increase salivary IgA but is not statistically significant. Keywords: Salivary IgA, probiotic solution, elderly

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Salivary IgA concentration in diabetic patients compared to healthy controls

Cited by 6 publications

References 0 publications

Functional and histological evaluation of bone marrow stem cell-derived exosomes therapy on the submandibular salivary gland of diabetic Albino rats through TGFβ/ Smad3 signaling pathway

Functional and histological evaluation of bone marrow stem cell-derived exosomes therapy on the submandibular salivary gland of diabetic Albino rats through TGFβ/ Smad3 signaling pathway

Effect of diabetes mellitus type 2 on salivary glucose, immunoglobulin A, total protein, and amylase levels in adults: A systematic review and meta-analysis of case–control studies

PENGARUH BERKUMUR DENGAN LARUTAN PROBIOTIK TERHADAP KADAR IgA DALAM SALIVA

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