Salivary Glands Tumors: A Single Institution Experience in Saudi Arabia

Sheddi, Manal A. Al

doi:10.13005/bbra/981

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…Similar results were replicated by Pinkston et al [25]. On the contrary, a study by Feinstein MT et al and Sheddi MAA identified adenoid cystic carcinoma as the most common histologic variant [21-22].…”

Section: Discussionsupporting

confidence: 65%

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Predictors for Salivary Gland Cancer Recurrence at Two Tertiary Hospitals in Saudi Arabia

Alraddadi

Aldhahri

Abdullakutty

et al. 2019

Cureus

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BackgroundTumors of salivary glands are enlarged as a low-risk mass and mostly benign in nature. The treatment of salivary gland malignancy remains quite challenging because of its relative infrequency, unreliable biological manners, and risk of re-emergence. For effective treatment planning, prediction of factors associated with the recurrence of salivary gland malignancy is essential.AimThe objective of this study was to identify the factors associated with recurrence of salivary gland malignancy at two tertiary hospitals in Saudi Arabia.Material and methodsA cross-sectional study was conducted at two tertiary hospitals in Saudi Arabia, where data of patients were recorded from the medical records of hospitals from 2012 to 2018. 63 patients who were diagnosed with salivary gland malignancy, whether originated from parotid, submandibular, sublingual, and minor salivary glands were included in the study. Descriptive statistics are shown in mean, frequency, and percentages, while comparative analysis was done using the Chi-square test, where p < 0.05 is considered significant.ResultsThis study included 63 participants. The majority of malignant salivary gland cancers arise from the parotid gland (47.6%), and mucoepidermoid carcinoma was the commonest form of malignancy in 36.5% of the studied population. Out of 63 patients, 17 had a recurrence of cancer, and the initial advanced stage of the disease is apparently associated with the re-emergence of salivary gland cancer.ConclusionThe initial advanced stage of cancer has a significant role in the recurrence of salivary gland malignancy. As salivary gland malignancy is rare and has unreliable behavior, establishing an adequate treatment plan prediction for recurrence is essential.

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Section: Discussionsupporting

confidence: 65%

“…The demographic distribution of this case-control study showed slightly more female distribution with the mean age of 44.4 years. In contrast, previous studies conducted by Feinstein MT et al and Sheddi MAA showed a male predominance [21-22].…”

Section: Discussionmentioning

confidence: 58%

Predictors for Salivary Gland Cancer Recurrence at Two Tertiary Hospitals in Saudi Arabia

Alraddadi

Aldhahri

Abdullakutty

et al. 2019

Cureus

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“…Curiously no basal cell adenomas were reported in Asia and South America, whereas they comprised 5% of benign SGT in the UK and 3% in both European and African centres. This could be related to the smaller number of cases gathered from these centres or the lower incidence as previous studies have shown that basal cell adenoma is not within the most common five benign tumours in these regions [ 22 , 23 , 27 ]. The possibility of variation in diagnostic criteria can also not be excluded.…”

Section: Discussionmentioning

confidence: 97%

Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study

Alsanie

Rajab

Cottom

et al. 2022

Head and Neck Pathol

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Background Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. To date, most of the epidemiological studies on salivary gland tumours are limited for a variety of reason including being out of date, extrapolated from either a single centre or country studies, or investigating either major or minor glands only. Methods This study aimed to mitigate these shortcomings by analysing epidemiological data including demographic, anatomical location and histological diagnoses of SGT from multiple centres across the world. The analysed data included age, gender, location and histological diagnosis from fifteen centres covering the majority of the world health organisation (WHO) geographical regions between 2006 and 2019. Results A total of 5739 cases were analysed including 65% benign and 35% malignant tumours. A slight female predilection (54%) and peak incidence between the fourth and seventh decade for both benign and malignant tumours was observed. The majority (68%) of the SGT presented in major and 32% in the minor glands. The parotid gland was the most common location (70%) for benign and minor glands (47%) for malignant tumours. Pleomorphic adenoma (70%), and Warthin’s tumour (17%), were the most common benign tumours whereas mucoepidermoid carcinoma (26%) and adenoid cystic carcinoma (17%) were the most frequent malignant tumours. Conclusions This multicentre investigation presents the largest cohort study to date analysing salivary gland tumour data from tertiary centres scattered across the globe. These findings should serve as a baseline for future studies evaluating the epidemiological landscape of these tumours.

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“…In addition, the peak prevalence of benign SGTs was in the 3rd decade, whereas malignant SGTs peak prevalence was in the 5th decade of life. It also reported that males are the predominant gender of all SGTs [7].…”

Section: Introductionmentioning

confidence: 93%

Major Salivary Glands Carcinoma in Saudi Arabia: A 10-Year Nationwide Retrospective Study of 571 Cases

Alsalem

AlKraidees

AlKarni

et al. 2022

Preprint

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Purpose: Major salivary glands carcinoma (MSGC) comprises a morphologically diverse group of rare tumours with different clinical behaviours, and studies on epidemiology in the literature vary greatly depending on the geographic location. The aim of this study was to conduct a comprehensive analysis of the incidence rates, anatomical sites, and histological subtypes of different salivary gland malignancies in the population of Saudi Arabia. Methods: A retrospective cohort study included patients diagnosed with primary major salivary glands carcinoma (MSGC) in Saudi Arabia from 2008 to 2017, based on the demographic characteristics and histological data retrieved from the Saudi Cancer Registry (SCR) database. Malignant lesions were identified using the International Classification of Diseases for Oncology, Third Edition (ICD-O-3) Codes. Results: Salivary gland malignancies were diagnosed in 571 patients over 10 years (50.10% were males and 49.90% females). The parotid gland was the site of origin in 69.9% of cases. The most common histological type was mucoepidermoid carcinoma (29.1%). Over a decade, the incidence rate ranged from (0.15 to 0.24), with the highest overall in 2009. The peak incidence of salivary gland malignancies was observed in the fourth, fifth and sixth decade of life (17.5%, 18.2%, and 16.8%, respectively). Conclusion: Major salivary gland carcinomas (MSGC) are extremely rare in the Saudi population, with a low incidence rate of only 0.15 to 0.24 cases per 100,000 person-year compared to other parts of the world. However, the clinical findings of Salivary gland carcinoma were similar to those described worldwide.

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Salivary Glands Tumors: A Single Institution Experience in Saudi Arabia

Cited by 3 publications

References 14 publications

Predictors for Salivary Gland Cancer Recurrence at Two Tertiary Hospitals in Saudi Arabia

Predictors for Salivary Gland Cancer Recurrence at Two Tertiary Hospitals in Saudi Arabia

Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study

Major Salivary Glands Carcinoma in Saudi Arabia: A 10-Year Nationwide Retrospective Study of 571 Cases

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