Salivary gland tumors in children and adolescents: a clinicopathologic and immunohistochemical study of fifty-three cases

Perez, Danyel Elias da Cruz; Pires, Fábio Ramôa; Alves, Fábio Abreu; Almeida, Oslei Paes de; Kowalski, Luiz Paulo

doi:10.1016/j.ijporl.2004.02.004

Cited by 103 publications

(82 citation statements)

References 34 publications

(64 reference statements)

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“…Cho et al (1997) showed a similar prevalence. However, some authors described a far greater rate, with almost 80% of the MEC positive for c-erbB-2 in their series, although the criteria for analysis of positivity was not presented (da Cruz Perez et al, 2004;Lopes et al). We observed c-erbB-2 membranous expression in 9 (31%) of cases in our series which is in accordance with previous report (Press et al).…”

Section: Discussionsupporting

confidence: 91%

Intraoral Mucoepidermoid Carcinoma of Salivary Glands: Lack of Association Among Clinicopathological Features and Immunoexpression of c-erbB-2 in 29 Cases

Bernardes¹,

Ramos-Jorge²,

Carmo³

et al. 2008

Int. J. Morphol.

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SUMMARY:The association among clinicopathological features and c-erbB-2 oncoprotein expression was evaluated in twentynine cases of intra-oral mucoepidermoid carcinoma (MEC). MEC was prevalent in the female gender (79.3%), tumors were more frequent in ages between 21 and 40 years (48.3%), and the palate was the most commonly affected site (72.4%). Microscopically, 27 cases (93.1%) were classified as low grade of malignancy. The c-erbB-2 expression was considered positive in 9 (31%) cases and no significant association (p>0.05) was found among protein expression and gender nor between patient age and site or histological grade of the lesion. c-erbB-2 expression in MEC may reflect intrisinc biologic properties of salivary gland neoplasms and may be linked to histogenesis and cellular differentiaton.

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Section: Discussionsupporting

confidence: 91%

Intraoral Mucoepidermoid Carcinoma of Salivary Glands: Lack of Association Among Clinicopathological Features and Immunoexpression of c-erbB-2 in 29 Cases

Bernardes¹,

Ramos-Jorge²,

Carmo³

et al. 2008

Int. J. Morphol.

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“…Unfortunately, while the study presents a qualitative description, it presents no quantitative description of expression [4]. Thus other biomarkers should be considered as alternative proliferation markers in salivary gland epithelial tumors in children and adolescents.…”

Section: Discussionmentioning

confidence: 98%

“…The pathological assessment of major salivary gland tumors should be based on an evaluation of histopathological features, and, if necessary, complementary analysis should be used to confirm the diagnosis [4].…”

Section: Introductionmentioning

confidence: 99%

Comparison between immunohistochemical expression of Ki-67 and MCM-3 in major salivary gland epithelial tumors in children and adolescents. Preliminary study

Zieliński¹,

Kobos²,

Zakrzewska³

2016

pjp

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While Ki-67 expression is frequently used as an indicator of tumor cell proliferation, alternative markers have also been proposed. Possible alternative indicators of proliferation are the minichromosome maintenance (MCM) proteins, whose levels are inversely associated with tumor cell differentiation. The aim of this preliminary study was to compare the levels of Ki-67 and MCM-3 expression in major salivary gland epithelial tumors in all children and adolescents who underwent surgery in our department in the years 2009-2014. The histopathological diagnosis of the subjects was reviewed, as well as the expression of Ki-67 and MCM-3 in post-op specimens of the tumors. The normality of data was checked with the Shapiro-Wilk test. The t test for independent variables or the U test was used as appropriate to determine statistically significant differences in the expression of Ki-67 and MCM-3. Five cases of pleomorphic adenoma, one of myoepithelioma, one of basal cell adenoma and one of mucoepidermoid carcinoma were identified. Significantly greater MCM-3 than Ki-67 expression was observed in every case. The results of our preliminary study emphasize the need for future research on MCM-3 as a sensitive proliferation marker, providing an alternative to Ki-67, in cases of various major salivary gland epithelial tumors in children and adolescents.

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“…Recurrences generally present as multiple nodes in the topography of the affected gland. This characteristic, however, may not be exclusive to recurrences, being seen in primary lesions as well [2,9]. Multiple nodes affecting the same region characterize the multicentric or multifocal behavior of a disease.…”

Section: Discussionmentioning

confidence: 99%

Pleomorphic Multicentric Adenoma in the Submandibular Gland

Alves

Júnior

Borba

et al. 2007

Head and Neck Pathol

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Neoplasms of salivary glands represent a small group among the diseases involving the head and neck complex. In this group, the pleomorphic adenoma is the most frequent neoplasm, yet involves the submandibular gland in only 12.3% of cases. A patient presenting a swelling in the region of the submandibular gland was submitted to an incisional biopsy, where a fragment of the gland and one juxtaposed node were removed. Histologically they were defined as pleomorphic adenoma. Later, the patient was submitted to submandibulectomy and two other nodes were found close to the gland and removed. All specimens were histologically defined as pleomorphic adenoma. This multicentric finding is of great interest, perhaps explaining the recurrence rate of this neoplasm. The patient is in continuous follow-up and has not presented signs of recurrence.

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Salivary gland tumors in children and adolescents: a clinicopathologic and immunohistochemical study of fifty-three cases

Cited by 103 publications

References 34 publications

Intraoral Mucoepidermoid Carcinoma of Salivary Glands: Lack of Association Among Clinicopathological Features and Immunoexpression of c-erbB-2 in 29 Cases

Intraoral Mucoepidermoid Carcinoma of Salivary Glands: Lack of Association Among Clinicopathological Features and Immunoexpression of c-erbB-2 in 29 Cases

Comparison between immunohistochemical expression of Ki-67 and MCM-3 in major salivary gland epithelial tumors in children and adolescents. Preliminary study

Pleomorphic Multicentric Adenoma in the Submandibular Gland

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