Salivary function impairment in type 2 Diabetes patients associated with concentration and genetic polymorphisms of chromogranin A

Kogawa, Evelyn Mikaela; Grisi, Daniela Corrêa; Falcão, Denise Pinheiro; Amorim, Ingrid Aquino; Rezende, Taia Maria Berto; Silva, Izabel Cristina Rodrigues da; Franco, Octávio L.; Amorim, Rivadávio Fernandes Batista de

doi:10.1007/s00784-015-1705-z

Cited by 21 publications

(18 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, the range of sCgA concentrations obtained in the current work (0-40 pmol/ml, excluding two extremely high values) was wider than the ones reported in most studies determining sCgA carried out in Japanese populations (highest values usually lower than 5 pmol/ml) [19,24,26,31,49]. Similar lower values were reported in Brazilian [50,53] and Indian subjects [51]. And contrarily, concentrations analogous to the ones in the present study were described in Italians [56], Austrians [48,55], French [11], and Koreans [57].…”

Section: Discussionsupporting

confidence: 69%

“…On the contrary, personal patterns of behavior were found to influence sCgA concentrations evaluated during stress relieving activities, such as woodland walking [34], and recently two polymorphisms in CgA gene (rs9658635 in the promoter region, and rs9658655 in exon 6, Glu264Asp) were also reported to modify sCgA [50]. A possible influence of all these factors on our results cannot be completely excluded, since patterns of behavior and genetic polymorphisms were not assessed.…”

Section: Discussioncontrasting

confidence: 60%

See 1 more Smart Citation

Is Salivary Chromogranin A a Valid Psychological Stress Biomarker During Sensory Stimulation in People with Advanced Dementia?

Valdiglesias

Maseda

Lorenzo-López

et al. 2016

JAD

View full text Add to dashboard Cite

Salivary chromogranin A (sCgA) is gaining attention as a biomarker of psychological stress. The objective of this work was to determine whether individualized music intervention and multisensory stimulation environment (MSSE) in a Snoezelen room produce changes in sCgA in severely demented older patients, and to assess the possible existence of differences in sCgA levels between the two types of interventions. Older adults with severe dementia (n = 22) were randomly assigned to two intervention groups. They participated in MSSE or individualized music interventions in 30-min weekly sessions for 16 weeks. Levels of sCgA were evaluated before and after a session, or 30-min interval, at four different time points: before starting the trial, in the middle and end of the intervention period, and two months later. Comparison of sCgA values obtained after each session with those obtained before (or at the same hour in before trial and follow-up samplings) showed no significant differences either in the individualized music or in the MSSE group at any sampling time. Comparison between the two types of interventions, both before and after each session, in the four sampling times, did not produce any significant difference either. Furthermore, no significant correlation was obtained between agitation, anxiety, cognitive function, and dementia severity with sCgA levels. In conclusion, despite beneficial effects of both individualized music and MSSE interventions being previously reported on neuropsychiatric outcomes for older patients with dementia, sCgA seems to not be a good indicator of these benefits.

show abstract

Section: Discussionsupporting

confidence: 69%

Section: Discussioncontrasting

confidence: 60%

Is Salivary Chromogranin A a Valid Psychological Stress Biomarker During Sensory Stimulation in People with Advanced Dementia?

Valdiglesias

Maseda

Lorenzo-López

et al. 2016

JAD

View full text Add to dashboard Cite

show abstract

“…Findings of salivary flow rates among patients with diabetes are conflicting 13 . Some studies have shown lower resting and/or stimulated salivary flow in both type 1 and 2 diabetes mellitus 9,14,15 , whereas other authors have found no differences between diabetic patients and controls 16 . Decrease in salivary flow in type 2 diabetic patients is less severe compared to type 1 diabetes.…”

Section: Salivary Flowmentioning

confidence: 95%

Oral alterations in diabetes mellitus

Cicmil¹,

Mladenović²,

Krunic³

et al. 2018

Balkan J Dent Med

View full text Add to dashboard Cite

SummaryDiabetes mellitus is one of the most common chronic diseases which continue to increase in number and significance. It presents the third most prevalent condition among medically compromised patients referring for dental treatment. Diabetes mellitus has been defined as a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Hyperglycemia leads to widespread multisystem damage which has an effect on oral tissue. The present article summarizes current knowledge regarding the association between diabetes mellitus and oral and dental health.

show abstract

“…Impaired salivary flow was correlated with significantly higher salivary and serum CgA levels. Two genetic variants of CHGA (rs9658635 and rs9658655) were associated with lower salivary flow and higher salivary CgA concentrations in T2DM [112].…”

Section: Chromogranin a In Type 2 Diabetes Mellitusmentioning

confidence: 96%

Chromogranina A i jej rola w patogenezie cukrzycy

Herold

Doleschall²,

Kövesdi

et al. 2018

Endokrynologia Polska

View full text Add to dashboard Cite

Chromogranin A is a member of the granin glycoprotein family that is expressed by the endocrine and neuroendocrine cells of different organs. Intracellularly, Chromogranin A contributes to the regulation of secretion, and gives several cleavage products after secretion. Some of its cleavage products modify the hormone functions in autocrine and paracrine ways, while the functions of others have not been fully understood yet. Serum Chromogranin A level is most prominently used in neuroendocrine tumor diagnostics. In addition, recent studies have suggested that Chromogranin A and some of its cleavage products, pancreastatin and WE-14, also play important roles in the pathogenesis of the various forms of diabetes mellitus, but their exact mechanisms still need to be clarified. Higher Chromogranin A, pancreastatin and WE-14 levels have been reported in type 1, type 2 and gestational diabetic patients compared to healthy controls. A notable connection has been inferred through the observation that type 1 diabetes mellitus is not at all or rarely developed in Chromogranin A gene-knockout, non-obese diabetic model mice compared to non-knockout, non-obese diabetic mice. Pancreastatin inhibits insulin release in various cell and animal models, and WE-14 serves as an autoantigen for both CD4+ and CD8+ beta cell-destructive diabetogenic T-cell clones in type 1 diabetes. Chromogranin A contributes to the pathogenesis of diabetes mellitus according to the available literature. The current findings facilitate further investigation to unravel the deeper relationships between this glycoprotein and diabetes.

show abstract

Salivary function impairment in type 2 Diabetes patients associated with concentration and genetic polymorphisms of chromogranin A

Cited by 21 publications

References 39 publications

Is Salivary Chromogranin A a Valid Psychological Stress Biomarker During Sensory Stimulation in People with Advanced Dementia?

Is Salivary Chromogranin A a Valid Psychological Stress Biomarker During Sensory Stimulation in People with Advanced Dementia?

Oral alterations in diabetes mellitus

Chromogranina A i jej rola w patogenezie cukrzycy

Contact Info

Product

Resources

About