Salivary duct carcinoma

Abstract

The aggressive SDC is increasingly diagnosed. Despite intensive combined surgery and radiation therapy, many patients recur, for whom new bullets, targeting the molecular biological mechanisms, are the subject of ongoing clinical trials.

The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

“…The lack of p63 staining will also distinguish SDC from metastatic squamous‐cell carcinoma. Up to a half of SDCs will demonstrate ERBB2 amplification by FISH or overexpression of HER2 by IHC . If present, PLAG1 and HMGA2 rearrangements suggest that an SDC arose as a carcinoma ex PA, though the lack of these cytogenetic alterations does not exclude this possibility.…”

“…Cytology smears reveal clusters of round to oval cells with fine to slightly granular chromatin and granular to dense cytoplasm with occasional intracytoplasmic vacuoles forming sheets, cribriform structures, or tubules. Nuclei are often pleomorphic with prominent nucleoli . Occasional binucleate or multinucleated cells are common (Figure ).…”

Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer

“…19 In a manner similar to ACC, PNI is a common feature of SDC, which is identified in 69% of cases and has been reported to be a negative prognostic factor for this high-grade aggressive tumor. 69 Other high-grade salivary gland histologies, such as high-grade mucoepidermoid carcinoma, are also associated with PNI. 70 The superficial and deep lobes of the parotid are separated by the facial nerve (VII), which gives rise to the 5 terminal branches within the gland that then innervate the muscles of facial expression.…”

The high expression of FOXA1 is correlated with a favourable prognosis in salivary duct carcinomas: a study of 142 cases

“…Salivary duct carcinoma (SDC) is an uncommon and aggressive tumour that accounts for approximately 10% of all salivary gland malignancies . It occurs not only as de‐novo carcinoma, but also as malignant transformation from pleomorphic adenoma.…”

“…A multivariate analysis revealed that SDCs with Introduction Salivary duct carcinoma (SDC) is an uncommon and aggressive tumour that accounts for approximately 10% of all salivary gland malignancies. [1][2][3] It occurs not only as de-novo carcinoma, but also as malignant transformation from pleomorphic adenoma. SDC is histologically comparable to high-grade mammary ductal carcinoma.…”