Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer

Bakst, Richard L.; Glastonbury, Christine M.; Parvathaneni, Upendra; Katabi, Nora; Hu, Kenneth; Yom, Sue S.

doi:10.1016/j.ijrobp.2018.12.009

Cited by 140 publications

(118 citation statements)

References 111 publications

(153 reference statements)

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“…Finally, expression of these same pro-tumorigenic neuronal migratory cues in ACC tumors identified a significantly poorer outcome subgroup of ACC tumors. These results potentially implicate ∆N Myb in stimulating perineural invasion in ACC tumors, the mechanisms of which are still largely unknown [56]. It will be exciting to see future studies that fully elucidate the role of TSS2 in MYB gene activation and expression, the extent of its interaction with hijacked enhancers, and its full functional consequences in ACC tumors.…”

Section: Discussionmentioning

confidence: 93%

N-Terminal Truncated Myb with New Transcriptional Activity Produced Through Use of an Alternative MYB Promoter in Salivary Gland Adenoid Cystic Carcinoma

Frerich

Sedam

Kang

et al. 2019

Cancers

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Adenoid cystic carcinoma (ACC) is an aggressive salivary gland tumor that frequently displays perineural invasion and is often associated with translocations or overexpression of the MYB oncogene. Detailed analyses of MYB transcripts from ACC patient samples revealed that ACC tumors utilize an alternative MYB promoter, which is rarely used in normal cells or other tumor types. The alternative promoter transcripts produce N-terminally truncated Myb proteins lacking a highly conserved and phosphorylated domain, which includes the pS11 epitope that is frequently used to detect Myb proteins. In RNA-seq assays, Myb isoforms lacking the N-terminal domain displayed unique transcriptional activities, regulating many genes differently than full-length Myb. Thus, a regulatory pathway unique to ACC activates the alternative MYB promoter, leading to the production of a truncated Myb protein with altered transcriptional activities. This could provide new therapeutic opportunities for ACC patients.

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Section: Discussionmentioning

confidence: 93%

N-Terminal Truncated Myb with New Transcriptional Activity Produced Through Use of an Alternative MYB Promoter in Salivary Gland Adenoid Cystic Carcinoma

Frerich

Sedam

Kang

et al. 2019

Cancers

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“…PNT is usually more readily evident on MR but may be found on CT with careful evaluation of known routes of spread. Evidence of perineural tumor may significantly alter the primary surgical plan and/or the radiation field [14].…”

Section: Staging Hn Sccmentioning

confidence: 99%

Head and Neck Squamous Cell Cancer: Approach to Staging and Surveillance

Glastonbury

2020

IDKD Springer Series

Self Cite

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“…In head and neck squamous cell carcinomas, PNI is reported in 25-80% of cases with relation to worse prognosis and increased risk of regional recurrences. In these groups of tumors, several parameters were measured, such as the number of involved nerves, nerve diameter or extratumoral versus intratumoral PNI occurrence [68].…”

Section: Pni In Pcmentioning

confidence: 99%

Complexity of Neural Component of Tumor Microenvironment in Prostate Cancer

et al. 2020

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The tumor microenvironment (TME) plays an essential role in the development and progression of neoplasms. TME consists of the extracellular matrix and numerous specialized cells interacting with cancer cells by paracrine and autocrine mechanisms. Tumor axonogenesis and neoneurogenesis constitute a developing area of investigation. Prostate cancer (PC) is one of the most common malignancies in men worldwide. During the past years, more and more studies have shown that mechanisms leading to the development of PC are not confined only to the epithelial cancer cell, but also involve the tumor stroma. Different nerve types and neurotransmitters present within the TME are thought to be important factors in PC biology. Moreover, perineural invasion, which is a common way of PC spreading, in parallel creates the neural niche for malignant cells. Cancer neurobiology seems to have become a new discipline to explore the contribution of neoplastic cell interactions with the nervous system and the neural TME component, also to search for potential therapeutic targets in malignant tumors such as PC.

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Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer

Cited by 140 publications

References 111 publications

N-Terminal Truncated Myb with New Transcriptional Activity Produced Through Use of an Alternative MYB Promoter in Salivary Gland Adenoid Cystic Carcinoma

N-Terminal Truncated Myb with New Transcriptional Activity Produced Through Use of an Alternative MYB Promoter in Salivary Gland Adenoid Cystic Carcinoma

Head and Neck Squamous Cell Cancer: Approach to Staging and Surveillance

Complexity of Neural Component of Tumor Microenvironment in Prostate Cancer

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