Salivary cortisol and DHEA reactivity to psychosocial stress in socially anxious males

Shirotsuki, Kentaro; Izawa, Shuhei; Sugaya, Nagisa; Yamada, Kosuke; Ogawa, Namiko; Ouchi, Yuko; Nagano, Yuichiro; Nomura, Shinobu

doi:10.1016/j.ijpsycho.2008.12.010

Cited by 68 publications

(66 citation statements)

References 53 publications

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“…Because DHEAS levels are also more stable and show no diurnal variation (Kroboth et al, 1999), they are often preferred in studies on long term effects of stress. Studies on acute stress, on the other hand, often assess DHEA, since DHEAS serves as a reservoir for DHEA biosynthesis and DHEA rather than DHEAS is expected to respond to acute psychosocial stress (Izawa et al, 2008;Morgan et al, 2004;Oberbeck et al, 1998;Pico-Alfonso et al, 2004;Shirotsuki et al, 2009). However, in a recent study, although the response of DHEA was more pronounced, both DHEA and DHEAS were found to increase in response to acute psychosocial stress (Lennartsson et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

The role of acute cortisol and DHEAS in predicting acute and chronic PTSD symptoms

Mouthaan

Sijbrandij²,

Luitse

et al. 2014

Psychoneuroendocrinology

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SummaryBackground: Decreased activation of the hypothalamus-pituitary-adrenal (HPA) axis in response to stress is suspected to be a vulnerability factor for posttraumatic stress disorder (PTSD). Previous studies showed inconsistent findings regarding the role of cortisol in predicting PTSD. In addition, no prospective studies have examined the role of dehydroepiandrosterone (DHEA), or its sulfate form DHEAS, and the cortisol-to-DHEA(S) ratio in predicting PTSD. In this study, we tested whether acute plasma cortisol, DHEAS and the cortisol-to-DHEAS ratio predicted PTSD symptoms at 6 weeks and 6 months post-trauma. Methods: Blood samples of 397 adult level-1 trauma center patients, taken at the trauma resuscitation room within hours after the injury, were analyzed for cortisol and DHEAS levels. PTSD symptoms were assessed at 6 weeks and 6 months post-trauma with the Clinician Administered PTSD Scale. Results: Multivariate linear regression analyses showed that lower cortisol predicted PTSD symptoms at both 6 weeks and 6 months, controlling for age, gender, time of blood sampling, injury, trauma history, and admission to intensive care. Higher DHEAS and a smaller cortisol-to-DHEAS ratio predicted PTSD symptoms at 6 weeks, but not after controlling for the same variables, and not at 6 months. Conclusions: Our study provides important new evidence on the crucial role of the HPA-axis in response to trauma by showing that acute cortisol and DHEAS levels predict PTSD symptoms in survivors of recent trauma. #

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Section: Introductionmentioning

confidence: 99%

The role of acute cortisol and DHEAS in predicting acute and chronic PTSD symptoms

Mouthaan

Sijbrandij²,

Luitse

et al. 2014

Psychoneuroendocrinology

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“…Likewise, the TSST has been used to test the relationship between stress and a variety of psychologic variables, such as depression (Parker, Schatzberg, & Lyons, 2003), social anxiety (Shirotsuki et al, 2009), and personality traits (Kirschbaum, Bartussek, & Strasburger, 1992;Pruessner et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

A virtual reality approach to the Trier Social Stress Test: Contrasting two distinct protocols

et al. 2015

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Virtual reality adaptations of the Trier Social Stress Test (TSST-VR) constitute useful tools for studying the physiologic axes involved in the stress response. Here, we aimed to determine the most appropriate experimental approach to the TSST-VR when investigating the modulation of the axes involved in the stress response. We compared the use of goggles versus a screen projection in the TSST-VR paradigm. Fortyfive healthy participants were divided into two groups: the first one (goggles condition; 13 females, 11 males) wore goggles while performing the TSST-VR; the second (screen condition; 15 females, six males) was exposed to the TSST-VR projected on a screen. Sympathetic reactivity to stress was measured by continuously recording skin conductance (SC), while the hypothalamic-pituitary-adrenal axis (HPA) was evaluated by sampling salivary cortisol throughout the experiment. At the end of the task, there was an increase in SC and cortisol level for both means of delivering the TSST-VR, although the increase in SC was greater in the goggles condition, while salivary cortisol was comparable in both groups. Immersion levels were reportedly higher in the screen presentation than in the goggles group. In terms of sex differences, females experienced greater involvement and spatial presence, though comparatively less experienced realism, than their male counterparts. These findings help us determine which protocol of the TSST-VR is most suitable for the stress response under study. They also emphasize the need to consider the sex of participants, as males and females show distinct responses in each protocol.

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“…This can be studied empirically using standardized social stress protocols measuring neurohormonal changes. The literature to date examining the cortisol stress response (CSR) following a social challenge in SAD has reported mixed results (Beaton et al, 2006;Condren et al, 2002;Furlan et al, 2001;Levin, 1993;Martel et al, 1999;Roelofs et al, 2009;Shirotsuki et al, 2009;van West et al, 2008;Yoon, 2012). One possible explanation for this inconsistency is that moderating factors such as childhood trauma (CT) have a greater influence on social stress responses and/or overall cortisol secretion than does the condition, itself.…”

Section: Introductionmentioning

confidence: 99%

The cortisol response to social stress in social anxiety disorder

Vaccarino

Levitan

Ravindran

2015

Asian Journal of Psychiatry

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Salivary cortisol and DHEA reactivity to psychosocial stress in socially anxious males

Cited by 68 publications

References 53 publications

The role of acute cortisol and DHEAS in predicting acute and chronic PTSD symptoms

The role of acute cortisol and DHEAS in predicting acute and chronic PTSD symptoms

A virtual reality approach to the Trier Social Stress Test: Contrasting two distinct protocols

The cortisol response to social stress in social anxiety disorder

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