Salivary Biomarkers of Physical Fatigue as Markers of Sleep Deprivation

Michael, Darren J.; Valle, Bianca; Cox, Jennifer; Kalns, John; Fogt, Donovan L.

doi:10.5664/jcsm.3280

Cited by 16 publications

(15 citation statements)

References 52 publications

(52 reference statements)

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“…In addition, salivary and serum cortisol levels are influenced by various stressors including insomnia, depression, and fatigue. The fatigue led by insomnia or other factors may be influenced by circadian rhythms 46 . Salivary amylase has also been identified as a biomarker for sleep deprivation in Drosophila and humans.…”

Section: Does Psychological Stress Make a Change In Salivary Protein mentioning

confidence: 99%

Compliance with Saliva Collection Protocol in Healthy Volunteers: Strategies for Managing Risk and Errors

2018

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Salivary bioscience technologies such as electrophoresis are widely applied for diagnosing systemic health status. Diagnosis using a saliva sample has emerged as a preferred technique since the sample is easy to collect and the method is inexpensive and non-invasive. Salivary diagnostics have even been identified as potential substitutes for serum protein biomarkers. However, the optimal protocol for collecting saliva has not yet been established. In many scientific settings, such as randomized controlled trials, sampling and statistical errors often occur when handling samples from healthy volunteers. These errors can be due to the psychological behavior of the volunteers, subject nonadherence, questionnaire characteristics, collection methods, and/or sample processing. The purpose of the review presented here is to outline the strategies for managing the risk factors and to minimize the sampling errors during saliva collection in healthy volunteers.

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Section: Does Psychological Stress Make a Change In Salivary Protein mentioning

confidence: 99%

Compliance with Saliva Collection Protocol in Healthy Volunteers: Strategies for Managing Risk and Errors

2018

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“…Mathematical model analysis was performed in several studies to screen the different indexes from the healthy control group from dozens of metabolites, such as cis-aconitate, socitrate, citrate and malate ( 43 ). Michael et al ( 44 ) found through metabolomics analysis that there were metabolites used as the fatigue markers in the saliva of athletes after three-day soccer game, namely 3-methylhistidine (short form: 3M-His), glucose-1-phosphate (short form: G-1-P), glucose 6-phosphate (short form: G-6-P) and some amino acid compound. However, the diagnostic efficacy of these markers was not further analyzed.…”

Section: Discussionmentioning

confidence: 99%

A prospective study on peptide mapping of human fatigue saliva markers based on magnetic beads

et al. 2019

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In order to explore convenient and stable fatigue markers, we studied various high-molecular-weight peptide fragments under fatigue state and non-fatigue state in the saliva using time of flight mass spectrometry. The saliva samples were collected from 10 healthy volunteers that were in the condition of fatigue and non-fatigue, respectively. Moreover, the time of flight mass spectrometry was conducted using two kinds of sample treatment methods, the magnetic beads enrichment (MB) and direct detection of stock solution. This was followed by modeling via the mass spectra of MB and supernatant (stock solution) directly collected after centrifugation. Both MB and direct sampling produced good spectrograms between 1,000 and 15,000 Da, while some peaks were lost in the enrichment. The spectrograms in the early and late period were different in each individual. Due to the limited sample size, 20 early and 20 late spectrograms were used for modeling analysis. Three different peptides were identified in the stock solution samples that can be detected in both fatigue and non-fatigue groups. The cross validity of MB model was 92.06%, while that of the stock solution model was 95.49%. The results showed that there were different peaks within the molecular weight of 2,000-15,000 Da, which provided a scientific basis for further realization of the convenient fatigue detection method based on the biosensor technique, with important theoretical and practical significance.

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“…It is possible, however, that younger mothers may be unable to adjust to the required lifestyle changes for their infants solely based on their physical strength prior to infant care. Infant care includes frequent feeds at night, which often results in substantial sleep loss, increasing risk of somatic symptoms, physical fatigue, depressive symptoms, and eating disorders (Broman, Lundh, & Hetta, ; Michael, Valle, Cox, Kalns, & Fogt, ; Tsuchiya et al ., ; Ulman et al ., ). Mothers who perceive such a lifestyle change as difficult may feel helpless to manage their new life with their infants after discharge; anxieties may increase while self‐confidence may decrease (Pond & Kemp, ).…”

Section: Discussionmentioning

confidence: 99%

Age‐specific determinants of post‐partum fatigue in primiparous women

Tsuchiya¹,

Mori

Sakajo

et al. 2015

Japan Journal Nursing Sci

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Primiparous mothers who anticipated new life with their infants to be difficult and who had an irregular lifestyle tended to report higher levels of fatigue during the post-partum hospital stay. Nurses and midwives should assess maternal sleep and eating conditions, providing support to ensure adequate maternal rest. Special efforts should be made to reduce anxiety about new life with infants among younger primiparous women who had experienced hyperemesis gravidarum.

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Salivary Biomarkers of Physical Fatigue as Markers of Sleep Deprivation

Cited by 16 publications

References 52 publications

Compliance with Saliva Collection Protocol in Healthy Volunteers: Strategies for Managing Risk and Errors

Compliance with Saliva Collection Protocol in Healthy Volunteers: Strategies for Managing Risk and Errors

A prospective study on peptide mapping of human fatigue saliva markers based on magnetic beads

Age‐specific determinants of post‐partum fatigue in primiparous women

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