Saliva and plasma levels of cardiac‐related biomarkers in post‐myocardial infarction patients

Abstract

Salivary cystatin C and GDF-15 could not differentiate between MI patients and controls.

Applications of the oral microbiome in personalized dentistry

“…For example, a newly emerged biomarker, a soluble form of triggering receptor expressed on myeloid cells-1 (TREM-1), is associated with increased systemic inflammatory burden in patients with periodontal disease (Bostanci, Ozturk, Emingil, & Belibasakis, 2013;Nylund et al, 2017) and deregulated local immune responses in the ageing population (Ozturk, Belibasakis, Emingil, & Bostanci, 2016). Another candidate biomarker that may confer high specificity and sensitivity for the connection between oral disease and systemic conditions is matrix metalloproteinase (MMP)-8 (Rathnayake et al, 2013;Rathnayake, Buhlin, et al, 2017;Rathnayake, Gieselmann, Heikkinen, Tervahartiala, & Sorsa, 2017). There is a clear need for more accurate molecular measures that identify the systemic burden of oral infections and their impact on general health.…”

Active MMP‐8 point‐of‐care (PoC)/chairside enzyme‐test as an adjunctive tool for early and real‐time diagnosis of peri‐implantitis

“…Previous studies demonstrate a large effect size for site‐specific aMMP‐8 measurements by immunofluorometric assay (IFMA) and POCT utilizing the same monoclonal antibodies in peri‐implantitis diagnostics (Alassiri et al, 2018 ; Golub et al, 2020 ; Lähteenmäki et al, 2020 ; Rathnayake et al, 2017 ; Sorsa, Bacigalupo, et al, 2020 ). Based on these studies, a minimum of 26 participants per group was calculated to identify the differences between healthy and peri‐implantitis groups with α = .05 and power = 0.80.…”

“…Previous studies demonstrate a large effect size for site-specific aMMP-8 measurements by immunofluorometric assay (IFMA) and POCT utilizing the same monoclonal antibodies in peri-implantitis diagnostics (Alassiri et al, 2018;Golub et al, 2020;Lähteenmäki et al, 2020;Rathnayake et al, 2017;Sorsa, Bacigalupo, et al, 2020).…”

Salivary levels of phosphorus and urea as indices of their plasma levels in nephropathic patients

“…The use of saliva for laboratory tests has been investigated in various medical areas because saliva could be used as a noninvasive diagnostic tool . An important prerequisite for the use of saliva in diagnostic workup is that the salivary levels of the marker associated with a given disorder should mirror the profile of the marker in biological samples used as gold standard in medical practice.…”

“…An important prerequisite for the use of saliva in diagnostic workup is that the salivary levels of the marker associated with a given disorder should mirror the profile of the marker in biological samples used as gold standard in medical practice. Previous observations indicated that correlations between plasma concentrations and saliva concentrations are detectable for some but not for all analytes . It is well established that small molecules as phosphorus and urea are measurable in saliva .…”