Saliva A review of its role in maintaining oral health and preventing dental disease

Dodds, Michael; Roland, Simon; Edgar, Michael; Thornhill, M

doi:10.1038/bdjteam.2015.123

Cited by 86 publications

(85 citation statements)

References 10 publications

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“…51 In the oral cavity, the mucosa is build up by squamous epithelial cells with underlying salivary glands, which continuously secrete saliva to protect oral and peri-oral tissues as well as to facilitate eating and speech. 52 Saliva consists of 99% water, but also contains mucin glycoproteins, hormones, vitamins, urea, several ions and antimicrobial peptides, which form the first line of defense for ingested pathogens. 53,54…”

Section: Mucus As An Additional Barriermentioning

confidence: 99%

Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties

et al. 2018

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Understanding the function of oral mucosal epithelial barriers is essential for a plethora of research fields such as tumor biology, inflammation and infection diseases, microbiomics, pharmacology, drug delivery, dental and biomarker research. The barrier properties are comprised by a physical, a transport and a metabolic barrier, and all these barrier components play pivotal roles in the communication between saliva and blood. The sum of all epithelia of the oral cavity and salivary glands is defined as the blood-saliva barrier. The functionality of the barrier is regulated by its microenvironment and often altered during diseases. A huge array of cell culture models have been developed to mimic specific parts of the blood-saliva barrier, but no ultimate standard in vitro models have been established. This review provides a comprehensive overview about developed in vitro models of oral mucosal barriers, their applications, various cultivation protocols and corresponding barrier properties.

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Section: Mucus As An Additional Barriermentioning

confidence: 99%

Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties

et al. 2018

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“…Saliva contains a large number of proteins, which play important roles in the regulation of the immune defence, endocrine system and maintenance of mucosal tissue and dental health23. The salivary glands are also integrated into the neuroendocrine system through complex regulatory pathways4.…”

mentioning

confidence: 99%

The proteomic profile of whole and glandular saliva in healthy pain-free subjects

Jasim

Olausson

Hedenberg-Magnusson

et al. 2016

Sci Rep

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Determination of the variability in the salivary proteome is a prerequisite for the development of saliva as a diagnostic and prognostic tool in particular physiological states. In this context, it is important that technical variability induced by sample collection and processing is kept at minimum to be able to reproducibly assess variability in states of health and disease. In the current study, the proteome profile in unstimulated and stimulated whole, parotid and sublingual saliva was investigated using two-dimensional gel electrophoresis. Saliva samples were structurally collected from ten examined and characterized healthy individuals during the exactly same conditions. The results demonstrated that different collection methods provide clear differences in the snapshot of the salivary proteome and also in the relative amount of specific proteins. The variable nature of the salivary proteome suggests that different approaches may have to be adopted when studying its composition or its possible role as an indicator for particular physiological states. The results emphasize the importance of consistency when collecting saliva samples for proteomic analysis.

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“…Two major groups of salivary functions were described: the first is protection of the oral tissues by means of lubrication, antibacterial activity, buffering capacity, enamel remineralisation and tissue repair, while the second is facilitating speech and eating by bolus preparation, enhancing mastication, swallowing, digestion and supporting speech by lubrication of the tongue and lips during movements 14 .…”

Section: Saliva As Physiological Fluidmentioning

confidence: 99%

Salivary theranostics in pediatric and special care dentistry

Petrović¹

2019

Balkan J Dent Med

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Summary Saliva as a microfluidic system offers numerous advantages for both general and oral health diagnostic and therapeutic procedures since its assembly is quick, stress-free, inexpensive and non-invasive. Moreover, saliva is frequently referred to as a mirror of the body due to the fact that it can reflect the physiological and pathological state of the body. More than a decade ago the term “Salivaomics” has been introduced with the aim of emphasizing the development of research, knowledge and applications of five salivary constituents: proteome, transcriptome, micro-RNA, metabolome, and microbiome. Contemporary oral health care delivery in pediatric and special care dentistry is focused toward the development of new diagnostic and therapeutical procedures that are essentially noninvasive due to common issue of intolerability to invasive procedures among these patients, with the possibility of increasing participation rates. Besides the criteria of being easily and non-invasive collected, there are additional standards that should be met before routine application in everyday clinical practice; the existence of specific biomarkers for a disease, and ability of having its biomarkers detected using present-day equipment. For example, there are recent suggestions that a salivary RNA panel could objectively differentiate children with autism spectrum disorder from their neurotypical peers. In addition, due to the ease of the administration, the oral cavity is an attractive site for the drug delivery systems development because through this route it is possible to realize mucosal and transmucosal, systemic effect. All these contemporary advances extended the salivary diagnostic approach from the oral to general health pointing towards a promising future of salivary diagnostics for personalized medicine devices.

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Saliva A review of its role in maintaining oral health and preventing dental disease

Cited by 86 publications

References 10 publications

Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties

Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties

The proteomic profile of whole and glandular saliva in healthy pain-free subjects

Salivary theranostics in pediatric and special care dentistry

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