Saliva- A Diagnostic Tool

Madalli, Vijaylaxmi

doi:10.9790/0853-1169699

Cited by 13 publications

(6 citation statements)

References 26 publications

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“…Peningkatan kadar lisozim saliva telah terbukti berhubungan dengan hipertensi yang merupakan tahap awal dari gangguan kardiovaskular. 21 Saliva penting dalam penggunaan untuk pemantauan obat dan deteksi obat-obatan terlarang. Saliva digunakan untuk mendeteksi keberadaan nikotin, cannabinoid, kokain, phencyclidine, opioid, barbiturat, diazepine, amfetamin, dan etanol.…”

Section: Gambar 7 Sarcoidosis 20unclassified

“…Selain itu nilai obat di dalam saliva berkorelasi dengan darah. 21,22 Analisis saliva telah banyak digunakan dalam forensik. Sampel saliva dapat dengan mudah diperoleh dari kacamata, rokok, produk makanan, amplop, dan sumber lain.…”

Section: Gambar 7 Sarcoidosis 20unclassified

“…DNA asing terdapat dalam saliva korban selama 60 menit sehingga memberikan bukti forensik yang berharga. 21,22 Subyek dengan stres dan rasa sakit dimonitor dalam perubahan biomarker saliva dapat memerlihatkan lebih banyak stres dan biomarker saliva nyeri yang diidentifikasi adalah amilase, substansi P, sekretorik IgA, kortisol, dan lisozim. Terdapat peningkatan level amilase saliva dan penurunan tingkat sekretori IgA dalam kondisi stres psikologis.…”

Section: Gambar 7 Sarcoidosis 20unclassified

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Saliva as a Potential Diagnostic of Biomarker of Oral and Systemic Diseases

2016

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Saliva is a biological fluid that is secreted by the major, minor and other accessories salivary glands. Saliva has a high potential as an indicator that reflects the health of our body. Saliva also plays an important role as a protector, lubricate oral structure with mucin, set a neutral pH through the buffer capacity, clean the oral cavity, stimulate wound healing, help the taste buds in the taste of food, facilitate the process of chewing food, form a bolus and make it easier swallowing, and minimize food particles through the activity of the enzyme amylase and lipase. The use of saliva as a biomarker in diagnosing provide more advantages than the serum and other body fluids due to using non-invasive techniques, cost-efficient, as well as methods for collecting samples for disease screening without the need to train professional personnel. The benefits derived from the saliva as a biomarker are early detection and screening of disease to the development of caries, periodontal disease, tumors and malignancy, hereditary, wound healing, autoimmune disease, infectious diseases, cardiovascular diseases, drug monitoring, forensic, and the psychological influence. At this time, the function of saliva as a diagnostic biomarker is not widely known, therefore the development of salivary further enhance because it can produce functional similarities with serum and reflect the body's physiological status in the oral cavity and systemic disease.

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Section: Gambar 7 Sarcoidosis 20unclassified

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Saliva as a Potential Diagnostic of Biomarker of Oral and Systemic Diseases

2016

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“…Salivary diagnostic could pave a path as an effective method for the early diagnosis of these diseases [1]. The clinical importance of saliva can have a varied range starting from the forensic field to drug monitoring followed by diagnosis of various local as well as systemic diseases [2].…”

Section: Introductionmentioning

confidence: 99%

Lite Image Analysis Module Salivary Diagnostic Tool - A Review

Saikia

Pachipulusu

Govindaraju

2021

JPRI

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Background: Saliva is a versatile biofluid that can help in detecting any oral or systemic disease of an individual. Saliva seems to be clinically an informative biofluid for easy prognosis of a disease and clinical or laboratory diagnosis of oral as well as many systemic diseases. It has some specific soluble biological markers that can be considered as an ideal approach for early detection of diseases. Aim: The aim of this paper was to review the recent developments of the Lite Image Analysis Module. Conclusion: Thus, this technology primarily helps in a rapid assessment of salivary biomarker levels signifying the probable systemic and oral condition of an individual both in quantitative as well as qualitative manner. Adopting a simple and quick technique, LIAM can be used effortlessly in some rural remote areas as well where advanced high technology laboratories have not yet reached. Clinical Significance: It is one of the recent advancements in the world of salivary diagnosis LIAM (Lite Image Analysis Module) that is a portable, light, hand-held scanning device which magnificently integrates a distinct analyte identification system that detects the type of analytes being tested and transfer the report straight to a smartphone or a Bluetooth devices.

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“…This is an ideal opportunity to optimize state-of-the-art saliva-based biosensors for salivary biomarkers that discriminate between diseases. [10]…”

Section: Introductionmentioning

confidence: 99%

Salivaomics: The current scenario

Shah

2018

J Oral Maxillofac Pathol

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For generations, blood has been the medium of choice for diagnosing most diseases and conditions. The reason for this is mainly the limitations of technology. The concept of oral diagnostics is preferred to more invasive methods. In recent years, it has become evident that the salivary constituents become detectably altered in response to certain disease states. Even so, what is most impressive is that salivary biomarkers not only arise in correlation with oral disorders but also those of distal tissues and organs. This suggests that oral fluids may represent a substantial reservoir of molecular and microbial information capable of communicating the onset or presence of disease throughout the body. An initiative of the National Institute of Dental and Craniofacial Research created a roadmap to achieve these goals whereby, with the use of oral fluids as the diagnostic medium, it would become possible to scrutinize the health and/or disease status of patients. The real promise of salivary analysis use is the ability of the patient or clinician to directly and continuously assess disease status, progression and therapeutic efficacy. The sensitive analysis may even allow presymptomatic diagnosis. There are five major diagnostic alphabets available in saliva namely, proteins, messenger RNAs, micro-RNAs (mi-RNAs), metabolic compounds and microbes which offer substantial advantages for salivary diagnostics because, the state of the disease may be associated with detectable changes in one, but not all, dimensions. Recently, the Salivaomics Knowledge Base (SKB) has been established by aligning the salivary biomarker discovery. The SKB constitutes data repository, management system and web resource fabricated to support human salivary proteomics, transcriptomics, miRNA, metabolomics and microbiome research.

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Saliva- A Diagnostic Tool

Cited by 13 publications

References 26 publications

Saliva as a Potential Diagnostic of Biomarker of Oral and Systemic Diseases

Saliva as a Potential Diagnostic of Biomarker of Oral and Systemic Diseases

Lite Image Analysis Module Salivary Diagnostic Tool - A Review

Salivaomics: The current scenario

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