Salinity-dependent mechanisms of copper toxicity in the galaxiid fish, Galaxias maculatus

Glover, Chris N.; Urbina, Mauricio A.; Harley, Rachel A.; Lee, Jacqueline A.

doi:10.1016/j.aquatox.2016.03.002

Cited by 22 publications

(5 citation statements)

References 45 publications

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“…One feature of the present study was the relatively high interindividual variability in the measured endpoints. This variability is in line with previous studies of this species , which reported standard errors rather than standard deviations as in the present study. Such variability is consistent with the responses of wild‐caught fish, relative to in‐bred laboratory species that show greater genetic homogeneity , and consequently the variation observed is likely to reflect the difference in responses under natural exposure scenarios.…”

Section: Discussionsupporting

confidence: 94%

“…In addition, inanga have been reported to inhabit natural waters that may reach pH values as low as 4.1 , which would further increase bioavailability of weak acids and alter speciation of trace metals. Furthermore, a recent study has shown that, in contrast to model fish species, inanga exposed to copper do not exhibit impaired ammonia excretion, thought to be a key mechanism of copper toxicity . These authors suggested that this was caused by the capacity of inanga skin to act as a “rescue pathway,” continuing to excrete ammonia and thus circumvent copper‐mediated inhibition of ammonia excretion at the gill.…”

Section: Introductionmentioning

confidence: 99%

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Acute exposure to an environmentally relevant concentration of diclofenac elicits oxidative stress in the culturally important galaxiid fish Galaxias maculatus

McRae

Glover

Burket

et al. 2017

Enviro Toxic and Chemistry

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Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) of growing concern in aquatic environments worldwide; nevertheless, knowledge of its effects on aquatic biota is restricted to a few model species with limited information regarding its mechanisms of impact. In the present study, diclofenac accumulation, its effects on metabolic rate, ionoregulation, and oxidative stress were examined at environmentally relevant (0.17 mg L À1 ) and elevated (763 mg L À1 ) concentrations in a culturally and economically important galaxiid fish, inanga (Galaxias maculatus), from the Southern Hemisphere. This species is among the most widespread freshwater fish in the world but its sensitivity to emerging contaminants is unknown. Following an acute 96-h exposure, bioconcentration of diclofenac was measured in the inanga whole-body, resulting in an estimated bioconcentration factor of 87 for the 0.17-mg L À1 exposure concentration, approaching values where transfer through the food chain should be considered. Lipid peroxidation in the liver was significantly elevated at both 0.17-and 763-mg L À1 exposure concentrations but lipid peroxidation in the kidney and gill decreased after diclofenac exposure. Catalase activity was also elevated in the liver of inanga but activity decreased in the gill. There were no effects of diclofenac on metabolic rate or ion (sodium and calcium) influx rates. These data indicate that toxicologically relevant adverse outcomes and bioconcentration of diclofenac at environmentally relevant levels warrant additional study in this important fish. Environ Toxicol Chem 2018;37:224-235. C 2017 SETAC

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Acute exposure to an environmentally relevant concentration of diclofenac elicits oxidative stress in the culturally important galaxiid fish Galaxias maculatus

McRae

Glover

Burket

et al. 2017

Enviro Toxic and Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has also been observed that, along with multiple stressors-especially heavy metalssalinity can modulate the OS in various fish models. Studies carried out on the euryhaline killifish Fundulus heteroclitus as a function of zinc, copper, and nickel by Loro et al [166], Blewett et al [167], and Ransberry et al [168], as well as by Glover et al [169] on the galaxiid fish Galaxias maculatus, have observed that salinity extensively modulated the OS physiology. Thus, it can be concluded that fish, being higher-taxon organisms, can activate various signaling systems such as the nuclear factor erythroid 2-related factor 2/Kelchlike ECH-associated protein 1 system to control OS-mediated salinity, but sometimes the collapse of the system may lead to OS in the fish.…”

Section: Fishesmentioning

confidence: 99%

Influence of Anthropogenic Activities on Redox Regulation and Oxidative Stress Responses in Different Phyla of Animals in Coastal Water via Changing in Salinity

Bal

Panda

Pati

et al. 2022

Water

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Salinity is a decisive abiotic factor that modulates the physiology of aquatic organisms. Salinity itself is modulated by various factors—most notably by anthropogenic factors. In coastal regions, increasing salinity is observed mostly due to the elevated rate of evaporation under high temperatures, especially under global warming. In addition, many other anthropogenic factors, climatic factors, chemicals, etc., also contribute to the changes in salinity in coastal water. Some of these include rainfall, regional warming, precipitation, moisture, thermohaline circulation, gaseous pollutants, dissolved chemicals, wind flow, and biocrusts. Salinity has been found to regulate the osmotic balance and, thus, can directly or indirectly influence the biomarkers of oxidative stress (OS) in aquatic organisms. Imbalances in OS potentially affect the growth, production, and reproduction of organisms; therefore, they are being studied in organisms of economic or aquacultural importance. Salinity-modulated OS and redox regulation as a function of phylum are covered in this review. The literature from 1960 to 2021 indicates that the altered OS physiology under changing salinity or in combination with other (anthropogenic) factors is species-specific, even within a particular phylum. Thus, knowing the response mechanisms of such organisms to salinity may be useful for the management of specific aquatic animals or their habitats.

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“…We identified Ca ion transmembrane transport, voltage-gated calcium channel activity, and Na ion transport as significantly enriched processes in the gill. Additionally, metals can cause the inhibition of the Na+/K+-ATPase pump (Glover et al, 2016;Grosell & Wood, 2002;Haverinen & Vornanen, 2023), and Cu can increase Cl loss (Mazon et al, 2002). Both potassium and chloride ion transporters were enriched, as well as voltage-gated potassium channels.…”

Section: Constitutive Gene Expression As a Potential Mechanism Of Ada...mentioning

confidence: 99%

The genomic signature and transcriptional response of metal tolerance in brown trout inhabiting metal-polluted rivers

Paris,

King,

Ferrer Obiol

et al. 2024

Preprint

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Industrial pollution is a major factor responsible for the degradation of ecosystems, but can also act as a driver of contemporary evolution. As a result of intense mining activity during the Industrial Revolution, several rivers across southwest England are polluted with high concentrations of metals. Despite the documented negative impacts of ongoing metal pollution, brown trout (Salmo truttaL.) survive and thrive in many of these metal-impacted rivers. We used population genomics, transcriptomics, and metal burdens to investigate the genomic and transcriptomic signatures of potential metal tolerance. RADseq of six populations (originating from three metal-impacted and three control rivers), identified strong genetic substructuring between metal-impacted populations, and selection signatures at 122 loci, including genes involved in metal homeostasis and oxidative stress. Measuring the tissue-metal burden (cadmium, copper, nickel, zinc) in metal-impacted and control trout populations, we identified significantly higher metals in metal-impacted trout sampled from the river, and also after 11 days of depuration in control water. After depuration, we used RNAseq to quantify gene expression differences between metal-impacted and control trout, identifying 2,042 differentially expressed genes (DEGs) in the gill, and 311 DEGs in the liver. Transcriptomic signatures in the liver were nuanced, but in the gill, ion transport processes were enriched, alongside the over-expression of genes involved in metal homeostasis, and response to oxidative stress, hypoxia and xenobiotics. Our results demonstrate the complexity of metal tolerance in vertebrates, and offer insights into the potential adaptive processes underpinning evolution to pollution in teleost fish.

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Salinity-dependent mechanisms of copper toxicity in the galaxiid fish, Galaxias maculatus

Cited by 22 publications

References 45 publications

Acute exposure to an environmentally relevant concentration of diclofenac elicits oxidative stress in the culturally important galaxiid fish Galaxias maculatus

Acute exposure to an environmentally relevant concentration of diclofenac elicits oxidative stress in the culturally important galaxiid fish Galaxias maculatus

Influence of Anthropogenic Activities on Redox Regulation and Oxidative Stress Responses in Different Phyla of Animals in Coastal Water via Changing in Salinity

The genomic signature and transcriptional response of metal tolerance in brown trout inhabiting metal-polluted rivers

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