Salient responsiveness of parabrachial neurons to the conditioned stimulus after the acquisition of taste aversion learning in rats

Shimura, Tsuyoshi; Tanaka, Hiroaki; Yamamoto, Takashi

doi:10.1016/s0306-4522(97)00188-7

Cited by 49 publications

(30 citation statements)

References 39 publications

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“…These results are generally in agreement with previous neurophysiological studies done in the rat and hamster PbN (Norgren and Pfaffmann 1975;Van Buskirk and Smith 1981;Ogawa et al 1984;Halsell and Frank 1991;Halsell and Travers 1997;Shimura et al 1997;Tokita et al 2004;Geran and Travers 2009). On the basis of the distribution pattern of recording sites of specific neuron types, some of these studied suggest the existence of chemotopy in the PbN (Van Buskirk and Smith 1981; Ogawa et al 1984;Yamamoto et al 1994;Shimura et al 1997;Tokita et al 2004; but see Geran and Travers 2009). One consistent finding of these studies is that more neurons responding best to acid stimuli appear to be preferentially located in the lateral PbN.…”

Section: Discussionsupporting

confidence: 90%

“…Finally it should be also noted that the anesthetic used might have an influence on spontaneous neural activity. However, our spontaneous firing rate is still lower than those in other studies recording from the NST or PbN using the same anesthetic, urethane (Adachi and Aoyama 1991;Boughter and Smith 1998;Lemon and Margolskee 2009;Cho and Li 2008;Shimura et al 1997;Tokita et al 2004). Another potential limitation of urethane is that it causes hyperglycemia (Reinert 1964), which suppresses neural responses to sapid sugars (Giza and Scott 1983).…”

Section: Discussionmentioning

confidence: 62%

“…Distribution of 11 taste stimuli in a 3-dimensional taste space resulting from multidimensional scaling. Shimura et al 1997;Tokita et al 2004). These results are plausible considering the findings that C57BL/6J mice have strong neural and behavioral sensitivity to sweeteners (Inoue et al 2004), and the mouse CT nerve appears to have more Q-best fibers than do other rodents (Ninomiya et al 1982;Ninomiya and Funakoshi 1989b).…”

Section: Discussionmentioning

confidence: 99%

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Gustatory neural responses to umami stimuli in the parabrachial nucleus of C57BL/6J mice

Tokita

Yamamoto

Boughter

2012

Journal of Neurophysiology

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Tokita K, Yamamoto T, Boughter JD Jr. Gustatory neural responses to umami stimuli in the parabrachial nucleus of C57BL/6J mice. J Neurophysiol 107: 1545-1555, 2012. First published December 14, 2011 doi:10.1152/jn.00799.2011Umami is considered to be the fifth basic taste quality and is elicited by glutamate. The mouse is an ideal rodent model for the study of this taste quality because of evidence that suggests that this species, like humans, may sense umami-tasting compounds as unique from other basic taste qualities. We performed single-unit recording of taste responses in the parabrachial nucleus (PbN) of anesthetized C57BL/6J mice to investigate the central representation of umami taste. A total of 52 taste-responsive neurons (22 sucrose-best, 19 NaCl-best, 5 citric acid-best, and 6 quinine-best) were recorded from stimulation period with a large panel of basic and umami-tasting stimuli. No neuron responded best to monopotassium glutamate (MPG) or inosine 5=-monophosphate (IMP), suggesting convergence of input in the central nervous system. Synergism induced by an MPG-IMP mixture was observed in all sucrose-best and some NaCl-best neurons that possessed strong sensitivity to sucrose. In more than half of sucrose-best neurons, the MPG-IMP mixture evoked stronger responses than those elicited by their best stimulus. Furthermore, hierarchical cluster analysis and multidimensional analysis indicated close similarity between sucrose and the MPG-IMP mixture. These results strongly suggest the mixture tastes sweet to mice, a conclusion consistent with previous findings that show bidirectional generalization of conditioned taste aversion between sucrose and umami mixtures, and suppression of taste responses to both sucrose and mixtures by the antisweet polypeptide gurmarin in the chorda tympani nerve. The distribution pattern of reconstructed recording sites of specific neuron types suggested chemotopic organization in the PbN. umami taste; mouse; amino acid; brainstem

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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Gustatory neural responses to umami stimuli in the parabrachial nucleus of C57BL/6J mice

Tokita

Yamamoto

Boughter

2012

Journal of Neurophysiology

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“…Training involving peripheral stimulation usually modifies the relative representation in primate auditory cortex (5) or in somatosensory cortices of both humans (23), nonhuman primates (24), and rodents (4,25). However, unlike the above cited studies, in our experiments maps rearrangement is caused not by a modification in the stimulus-receptor interaction at the periphery (the bottom-up inputs) but rather by viscero-gustatory interaction that might occur from top-down modulations in early brainstem relays, such as the nucleus of solitary tract (26,27), the parabrachial nucleus (28,29), or CTA-related forebrain centers, such as basolateral amygdala (10) and primary GC (11,12).…”

Section: Discussionmentioning

confidence: 48%

Internal body state influences topographical plasticity of sensory representations in the rat gustatory cortex

Accolla

Carleton²

2008

Proc. Natl. Acad. Sci. U.S.A.

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Primary sensory cortices are remarkably organized in spatial maps according to specific sensory features of the stimuli. These cortical maps can undergo plastic rearrangements after changes in afferent (''bottom-up'') sensory inputs such as peripheral lesions or passive sensory experience. However, much less is known about the influence of ''top-down'' factors on cortical plasticity. Here, we studied the effect of a visceral malaise on taste representations in the gustatory cortex (GC). Using in vivo optical imaging, we showed that inducing conditioned taste aversion (CTA) to a sweet and pleasant stimulus induced plastic rearrangement of its cortical representation, becoming more similar to a bitter and unpleasant taste representation. Using a behavior task, we showed that changes in hedonic perception are directly related to the maps plasticity in the GC. Indeed imaging the animals after CTA extinction indicated that sweet and bitter representations were dissimilar. In conclusion, we showed that an internal state of malaise induces plastic reshaping in the GC associated to behavioral shift of the stimulus hedonic value. We propose that the GC not only encodes taste modality, intensity, and memory but extends its integrative properties to process also the stimulus hedonic value.chemical senses ͉ map plasticity ͉ taste coding

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“…Several studies (Chang & Scott, 1984;Shimura, Tanaka, & Yamamoto, 1997;Shimura, Tokita, & Yamamoto, 2002;Tamura & Norgren, 1997) have shown significant differences in neural gustatory coding in the PBN or nucleus of the solitary tract between groups of rats with or without prior CTA training, although evidence of single-neuron shifts is limited to one study of insular cortex recordings (Yasoshima & Yamamoto, 1998). The rapid formation of CTA evidenced here suggests that direct, real-time neural evidence of CTA formation can be obtained at other nuclei implicated in CTA (e.g., the PBN).…”

Section: Temporal Dynamics Of Cta Formationmentioning

confidence: 66%

Temporal and Qualitative Dynamics of Conditioned Taste Aversion Processing: Combined Generalization Testing and Licking Microstructure Analysis.

Baird

John

Nguyen

2005

Behavioral Neuroscience

133

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The pattern of licking microstructure during various phases of a conditioned taste aversion (CTA) was evaluated. In Experiment 1, rats ingested lithium chloride (LiCl) for 3 trials and were then offered sodium chloride (NaCl) or sucrose on 3 trials. A CTA to LiCl developed and generalized to NaCl but not to sucrose. CTA intake suppression was characterized by reductions in burst size, average ingestion rate, and intraburst lick rate, and increases in brief pauses and burst counts. Compared with previous studies, LiCl licking shifted from a pattern initially matching that for normally accepted NaCl to one matching licking for normally avoided quinine hydrochloride by the end of the 1st acquisition trial. In Experiment 2, a novel paradigm was developed to show that rats expressed CTA generalization within 9 min of their first LiCl access. These results suggest that licking microstructure analysis can be used to assay changes in hedonic evaluation caused by treatments that produce aversive states.

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Salient responsiveness of parabrachial neurons to the conditioned stimulus after the acquisition of taste aversion learning in rats

Cited by 49 publications

References 39 publications

Gustatory neural responses to umami stimuli in the parabrachial nucleus of C57BL/6J mice

Gustatory neural responses to umami stimuli in the parabrachial nucleus of C57BL/6J mice

Internal body state influences topographical plasticity of sensory representations in the rat gustatory cortex

Temporal and Qualitative Dynamics of Conditioned Taste Aversion Processing: Combined Generalization Testing and Licking Microstructure Analysis.

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