Salience, emotion, and attention: The neural networks underlying tinnitus distress revealed using music and rest

Shahsavarani, Somayeh; Schmidt, Sara A.; Khan, Rafay A.; Tai, Yihsin; Husain, Fatima T.

doi:10.1016/j.brainres.2021.147277

Cited by 18 publications

(13 citation statements)

References 58 publications

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“…Previous studies [30,41,42] have shown that the functional activity of the precuneus was decreased in normal people at rest; thus, in the resting state, it is unnecessary for people to devote much neural activity to high-level cognition. Our study was similar to that by Shahsavarani et al [6] and Schmidt et al [23]. We found that the functional activity of the precuneus in the tinnitus patients was lower than that in the healthy control group.…”

Section: Discussionsupporting

confidence: 92%

“…Braga et al [32] found that the FEF is involved in auditory attention. Lan et al [33] and Shahsavarani et al [6] found changes in the functional connections of the superior frontal gyrus in patients with tinnitus. Our findings show that the FC of several brain regions within the DAN was increased and likely confirm the conjecture that tinnitus, visual attention, and auditory attention influence each other, echoing Shahsavarani et al's [6] study.…”

Section: Discussionmentioning

confidence: 98%

“…Tinnitus occurs at all ages and affects 10-25% of people worldwide [1,4]. Patients with persistent tinnitus also experience problems such as anxiety, hearing loss, insomnia, depression, decreased attention, and cognitive impairment, which have some impact on their lives [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…To date, there is no final conclusion regarding the mechanism underlying tinnitus, but as a result of in-depth studies, it is widely believed that sustained tinnitus involves multisystem participation and impact [1,6,7]. Based on this theory, emotion, attention, memory, and control networks all contribute to the abnormal sound perception of tinnitus and the generation and development of related features.…”

Section: Introductionmentioning

confidence: 99%

“…Previously, some researchers thought that tinnitus may be a result of the maladaptation of the auditory nervous system [17]. However, studies based on fMRI [6,18] have reported that the auditory neural networks of patients with tinnitus do not significantly change. This finding suggests that the neurological activity of the auditory network may not play a role in tinnitus.…”

Section: Introductionmentioning

confidence: 99%

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Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus

Lyu

et al. 2021

Neural Plasticity

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Previous functional magnetic resonance imaging (fMRI) analyses have shown that the dorsal attention network (DAN) is involved in the pathophysiological changes of tinnitus, but few relevant studies have been conducted, and the conclusions to date are not uniform. The purpose of this research was to test whether there is a change in intrinsic functional connectivity (FC) patterns between the DAN and other brain regions in tinnitus patients. Thirty-one patients with persistent tinnitus and thirty-three healthy controls were enrolled in this study. A group independent component analysis (ICA), degree centrality (DC) analysis, and seed-based FC analysis were conducted. In the group ICA, the tinnitus patients showed increased connectivity in the left superior parietal gyrus in the DAN compared to the healthy controls. Compared with the healthy controls, the tinnitus patients showed increased DC in the left inferior parietal gyrus and decreased DC in the left precuneus within the DAN. The clusters within the DAN with significant differences in the ICA or DC analysis between the tinnitus patients and the healthy controls were selected as regions of interest (ROIs) for seeds. The tinnitus patients exhibited significantly increased FC from the left superior parietal gyrus to several brain regions, including the left inferior parietal gyrus, the left superior marginal gyrus, and the right superior frontal gyrus, and decreased FC to the right anterior cingulate cortex. The tinnitus patients exhibited decreased FC from the left precuneus to the left inferior occipital gyrus, left calcarine cortex, and left superior frontal gyrus compared with the healthy controls. The findings of this study show that compared with healthy controls, tinnitus patients have altered functional connections not only within the DAN but also between the DAN and other brain regions. These results suggest that it may be possible to improve the disturbance and influence of tinnitus by regulating the DAN.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus

Lyu

et al. 2021

Neural Plasticity

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Striatal networks for tinnitus treatment targeting

Larson

Sabes

Mizuiri

et al. 2021

Human Brain Mapping

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Neuromodulation treatment effect size for bothersome tinnitus may be larger and more predictable by adopting a target selection approach guided by personalized striatal networks or functional connectivity maps. Several corticostriatal mechanisms are likely to play a role in tinnitus, including the dorsal/ventral striatum and the putamen. We examined whether significant tinnitus treatment response by deep brain stimulation (DBS) of the caudate nucleus may be related to striatal network increased functional connectivity with tinnitus networks that involve the auditory cortex or ventral cerebellum. The first study was a cross‐sectional 2‐by‐2 factorial design (tinnitus, no tinnitus; hearing loss, normal hearing, n = 68) to define cohort level abnormal functional connectivity maps using high‐field 7.0 T resting‐state fMRI. The second study was a pilot case–control series (n = 2) to examine whether tinnitus modulation response to caudate tail subdivision stimulation would be contingent on individual level striatal connectivity map relationships with tinnitus networks. Resting‐state fMRI identified five caudate subdivisions with abnormal cohort level functional connectivity maps. Of those, two connectivity maps exhibited increased connectivity with tinnitus networks—dorsal caudate head with Heschl's gyrus and caudate tail with the ventral cerebellum. DBS of the caudate tail in the case‐series responder resulted in dramatic reductions in tinnitus severity and loudness, in contrast to the nonresponder who showed no tinnitus modulation. The individual level connectivity map of the responder was in alignment with the cohort expectation connectivity map, where the caudate tail exhibited increased connectivity with tinnitus networks, whereas the nonresponder individual level connectivity map did not.

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Abnormal Functional Connectivity Within Default Mode Network and Salience Network Related to Tinnitus Severity

Xiong

Liu

et al. 2023

JARO

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Salience, emotion, and attention: The neural networks underlying tinnitus distress revealed using music and rest

Cited by 18 publications

References 58 publications

Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus

Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus

Striatal networks for tinnitus treatment targeting

Abnormal Functional Connectivity Within Default Mode Network and Salience Network Related to Tinnitus Severity

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